The DOI matches its Crossref record; 138 of the 138 references it cites were found in a registry or an index.
The multifaceted role of fibrinogen in tissue injury and inflammation
Open accessAbstract
The canonical role of the hemostatic and fibrinolytic systems is to maintain vascular integrity. Perturbations in either system can prompt primary pathological end points of hemorrhage or thrombosis with vessel occlusion. However, fibrin(ogen) and proteases controlling its deposition and clearance, including (pro)thrombin and plasmin(ogen), have powerful roles in driving acute and reparative inflammatory pathways that affect the spectrum of tissue injury, remodeling, and repair. Indeed, fibrin(ogen) deposits are a near-universal feature of tissue injury, regardless of the nature of the inciting event, including injuries driven by mechanical insult, infection, or immunological derangements. Fibrin can modify multiple aspects of inflammatory cell function by engaging leukocytes through a variety of cellular receptors and mechanisms. Studies on the role of coagulation system activation and fibrin(ogen) deposition in models of inflammatory disease and tissue injury have revealed points of commonality, as well as context-dependent contributions of coagulation and fibrinolytic factors. However, there remains a critical need to define the precise temporal and spatial mechanisms by which fibrinogen-directed inflammatory events may dictate the severity of tissue injury and coordinate the remodeling and repair events essential to restore normal organ function. Current research trends suggest that future studies will give way to the identification of novel hemostatic factor-targeted therapies for a range of tissue injuries and disease.
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Cites
The Metabolic and Molecular Bases of Inherited Disease
Scriver, R. C. (1995) · Medical Entomology and Zoology · Cited by 12,101
Pathogenesis of osteoporosis: concepts, conflicts, and prospects
Raisz, L. G. (2005) · Journal of Clinical Investigation · doi:10.1172/jci27071 · Cited by 1,779
Fibrinogen Stimulates Macrophage Chemokine Secretion Through Toll-Like Receptor 4
Smiley, S. T., King, J. A., & Hancock, W. W. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.5.2887 · Cited by 946
Interleukin‐6 is the major regulator of acute phase protein synthesis in adult human hepatocytes
Castell, J. V., Gómez-Lechón, M. J., David, M., Andus, T., Geiger, T., Trullenque, R., Fabra, R., & Heinrich, P. C. (1989) · FEBS Letters · doi:10.1016/0014-5793(89)80476-4 · Cited by 893
Activation of Endothelial Cell Protease Activated Receptor 1 by the Protein C Pathway
Riewald, M., Petrovan, R. J., Donner, A., Mueller, B. M., & Ruf, W. (2002) · Science · doi:10.1126/science.1071699 · Cited by 831
Castell, J. V., Gómez-lechón, M. J., David, M., Fabra, R., Trullenque, R., & Heinrich, P. C. (1990) · Hepatology · doi:10.1002/hep.1840120517 · Cited by 757
RANTES Deposition by Platelets Triggers Monocyte Arrest on Inflamed and Atherosclerotic Endothelium
von Hundelshausen, P., Weber, K. S. C., Huo, Y., Proudfoot, A. E. I., Nelson, P. J., Ley, K., & Weber, C. (2001) · Circulation · doi:10.1161/01.cir.103.13.1772 · Cited by 584
Diamond, M. S., Garcia-Aguilar, J., Bickford, J. K., Corbi, A. L., & Springer, T. A. (1993) · The Journal of cell biology · doi:10.1083/jcb.120.4.1031 · Cited by 533
Infection and inflammation and the coagulation system
Levi, M. (2003) · Cardiovascular Research · doi:10.1016/s0008-6363(02)00857-x · Cited by 517
Osteoporosis in Patients With Diabetes Mellitus
Hofbauer, L. C., Brueck, C. C., Singh, S. K., & Dobnig, H. (2007) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.070510 · Cited by 503
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Developing fibrin-based biomaterials/scaffolds in tissue engineering
Li, S., Dan, X., Chen, H., Li, T., Liu, B., Ju, Y., Li, Y., Lei, L., & Fan, X. (2024) · Bioactive Materials · doi:10.1016/j.bioactmat.2024.08.006 · Cited by 107
Nencini, F., Bettiol, A., Argento, F. R., Borghi, S., Giurranna, E., Emmi, G., Prisco, D., Taddei, N., Fiorillo, C., & Becatti, M. (2024) · Molecular Biomedicine · doi:10.1186/s43556-024-00214-x · Cited by 49
Zheng, Z., Nakamura, K., Gershbaum, S., Wang, X., Thomas, S., Bessler, M., Schrope, B., Krikhely, A., Liu, R.-M., Ozcan, L., et al. (2020) · Journal of Clinical Investigation · doi:10.1172/jci135919 · Cited by 43
Li, R., Liu, J., Ma, J., Sun, X., Wang, Y., Yan, J., Yu, Q., Diao, J., Yang, C., Reid, L. M., et al. (2022) · Biomaterials · doi:10.1016/j.biomaterials.2021.121266 · Cited by 30
Metadata
- Authors
- Luyendyk, J. P., Schoenecker, J. G., & Flick, M. J.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2019-02-07
- Volume
- 133
- Issue
- 6
- Pages
- 511-520
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W2903302497
- Cited by
- 555
- References
- 138
- FWCI
- 24.01
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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