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Cited by 107Silk-based biomaterials and applicationsBlood properties and coagulationHemostasis and retained surgical items

Developing fibrin-based biomaterials/scaffolds in tissue engineering

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Li, Songjie, Dan, Xin, Chen, Han, Li, Tong, Liu, Bo, Ju, Yikun, Li, Yang, Lei, Lanjie +1 more·2024·Bioactive Materials
DOI 10.1016/j.bioactmat.2024.08.006PMC PMC11375146
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Abstract

Tissue engineering technology has advanced rapidly in recent years, offering opportunities to construct biologically active tissues or organ substitutes to repair or even enhance the functions of diseased tissues and organs. Tissue-engineered scaffolds rebuild the extracellular microenvironment by mimicking the extracellular matrix. Fibrin-based scaffolds possess numerous advantages, including hemostasis, high biocompatibility, and good degradability. Fibrin scaffolds provide an initial matrix that facilitates cell migration, differentiation, proliferation, and adhesion, and also play a critical role in cell-matrix interactions. Fibrin scaffolds are now widely recognized as a key component in tissue engineering, where they can facilitate tissue and organ defect repair. This review introduces the properties of fibrin, including its composition, structure, and biology. In addition, the modification and cross-linking modes of fibrin are discussed, along with various forms commonly used in tissue engineering. We also describe the biofunctionalization of fibrin. This review provides a detailed overview of the use and applications of fibrin in skin, bone, and nervous tissues, and provides novel insights into future research directions for clinical treatment.

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  • A significant impediment to the broad adoption of fibrin-based barriers is the considerable challenges and expenses inherent in their large-scale manufacturing, considering the fibrin molecule's origin in blood plasma.

    “Consequently, a significant impediment to the broad adoption of fibrin-based barriers stems from the considerable challenges and expenses inherent in their large-scale manufacturing, considering the fibrin molecule’s origin in blood plasma [78,79].”

    From Biomaterials in Postoperative Adhesion Barriers and Uterine Tissue Engineering (2025) · cites this paper as [79]

    The Fibrin glue section (page not provided) says fibrinogen can be obtained from plasma and that preparing autologous fibrin glue is relatively complex; it also mentions newer, more cost-effective production methods. It does not establish that large-scale manufacturing costs impede broad adoption of fibrin-based barriers. (LLM, conf=0.78)

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200 of 225 shown

Cited by

Sorted by citations

Authors
Li, S., Dan, X., Chen, H., Li, T., Liu, B., Ju, Y., Li, Y., Lei, L., & Fan, X.
Affiliations
  • Xijing Hospital (CN)
  • Central South University (CN)
  • Zhejiang Shuren University (CN)
Corresponding author
  • Li, Yang
  • Lei, Lanjie
  • Fan, Xing
ORCID
Venue
Bioactive Materials
Publisher
Elsevier BV
Published
2024-10
Volume
40
Pages
597-623
ISSN
  • 2097-1192 (ISSN-L)
  • 2452-199X
DOI
10.1016/j.bioactmat.2024.08.006
PMC
PMC11375146
OpenAlex
W4401596305
Cited by
107
References
5
Citations by year
2026: 39 · 2025: 61 · 2024: 7
FWCI
2.90
Type
journal article
Language
en
Open access
Licence
Locations
  • Bioactive Materials (publishedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • Nanjing Medical University
  • Education Department of Shaanxi Provincial government (YJSZG2023134)
Topics
  • Physical Sciences › Materials Science › Biomaterials › Silk-based biomaterials and applications
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Blood properties and coagulation
  • Health Sciences › Medicine › Hematology › Hemostasis and retained surgical items
Keywords
fibrin, tissue engineering, extracellular matrix mimicry, fibrin cross-linking, biofunctionalization, cell-matrix interactions, skin tissue engineering, bone tissue engineering, hemostasis, biocompatibility, degradability

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