Incidence of lymphoid neoplasms among atomic bomb survivors by histological subtype, 1950 to 1994
Open accessAbstract
Epidemiological data have provided limited and inconsistent evidence on the relationship between radiation exposure and lymphoid neoplasms. We classified 553 lymphoid neoplasm cases diagnosed between 1950 and 1994 in the Life Span Study cohort of atomic bomb survivors into World Health Organization subtypes. Mature B-cell neoplasms represented 58%, mature T-cell and natural killer (NK)-cell neoplasms 20%, precursor cell neoplasms 5%, and Hodgkin lymphoma (HL) 3%, with the remaining 15% classified as non-Hodgkin lymphoid (NHL) neoplasms or lymphoid neoplasms not otherwise specified. We used Poisson regression methods to assess the relationship between radiation exposure and the more common subtypes. As in earlier reports, a significant dose response for NHL neoplasms as a group was seen for males but not females. However, subtype analyses showed that radiation dose was strongly associated with increased precursor cell neoplasms rates, with an estimated excess relative risk per Gy of 16 (95% Confidence interval: 7.0, >533) at age 50. The current data based primarily of tissue-based diagnoses suggest that the association between radiation dose and lymphoid neoplasms as a group is largely driven by the radiation effect on precursor cell neoplasms while presenting no evidence of a radiation dose response for major categories of mature cell neoplasms, either B- or T-/NK-cell, or more specific disease entities (diffuse large B-cell lymphoma, plasma cell myeloma, adult T-cell leukemia/lymphoma) or HL.
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Using the revised WHO classification, the ERR/100 mGy for non-Hodgkin lymphoma among those with attained age below 35 was 0.88 (95% CI 0.36 to 3.6), based on small numbers of cases.
“Using the revised WHO classification of lymphoid malignancies37, the ERR/100 mGy for NHL among those with attained age below 35 was 0.88 (95% CI 0.36 to 3.6), based on small numbers of cases (Ritsu Sakata, personal communication).”
From Risk of hematological malignancies from CT radiation exposure in children, adolescents and young adults (2023) · cites this paper as [37]
To our knowledge, the revised WHO classification has only been used in a re-analysis of lymphoma incidence in the atomic bomb survivor cohort.
“To our knowledge, the revised classification has only been used in a re-analysis of lymphoma incidence in the atomic bomb survivor cohort37.”
From Risk of hematological malignancies from CT radiation exposure in children, adolescents and young adults (2023) · cites this paper as [37]
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- Authors
- Fujihara, M., Sakata, R., Yoshida, N., Ozasa, K., Preston, D. L., & Mabuchi, K.
- Affiliations
- Hiroshima Red Cross Hospital & Atomic-bomb Survivors Hospital (JP)
- Department of Epidemiology, and
- Radiation Effects Research Foundation (JP)
- Hirosoft International Corporation, Eureka, CA; and
- Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2022-01-13
- Volume
- 139
- Issue
- 2
- Pages
- 217-227
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- PMC
- PMC8759532
- OpenAlex
- W3195841107
- Cited by
- 7
- References
- 19
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 1 · 2023: 2
- FWCI
- 0.40
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Blood (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Japan Society for the Promotion of Science (19K16574)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Effects of Radiation Exposure
- Health Sciences › Medicine › Pathology and Forensic Medicine › Lymphoma Diagnosis and Treatment
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Radiation Dose and Imaging
- Keywords
- lymphoid malignancies, atomic bomb survivors, radiation exposure, histological subtypes, non-Hodgkin lymphoma, Hodgkin's disease, B-cell malignancies, dose-response relationship, Life Span Study, excess relative risk
- MeSH terms
- Atomic Bomb Survivors, Adolescent, Adult, Female, Humans, Leukemia, Lymphoid, Lymphoma, Male, Middle Aged, Neoplasms, Radiation-Induced, Radioactive Fallout, Risk, World Health Organization, Incidence, Young Adult
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