The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
The Liver as a Source of Extrarenal Erythropoietin Production
Open accessAbstract
Abstract Nephrectomized rats exposed to intense hypoxia produce sufficient erythropoietin (Ep) to detectably increase their plasma Ep titers. Extrarenal Ep production is no longer detectable if nephrectomized rats are also subjected to 80% hepatectomy prior to being made hypoxic at 0.465 atmos and is barely detectable but significantly lower than in nephrectomized rats when exposed to 0.435 atmos. These results suggest that the liver plays an important role in the production of extrarenal erythropoietin.
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“However, in adults, the liver retains its ability to produce EPO in response to moderate/severe hypoxia or to pharmacologic HIF activation. 23–25”
From Regulation of erythropoiesis by hypoxia-inducible factors (2013) · cites this paper as [23]
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Citations
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Metadata
- Authors
- Fried, W.
- Affiliations
- University of Illinois Chicago (US)
- Corresponding author
- Fried, Walter
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 1972-11-01
- Volume
- 40
- Issue
- 5
- Pages
- 671-677
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W200215156
- Cited by
- 235
- References
- 18
- Citations by year
- 2024: 2 · 2023: 2 · 2022: 1 · 2021: 1 · 2020: 3 · 2019: 3 · 2018: 2 · 2017: 3 · 2016: 2 · 2015: 3 · 2014: 4 · 2013: 3 · 2012: 3
- FWCI
- 3.87
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Blood (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hematology › Erythropoietin and Anemia Treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Hemoglobin structure and function
- Health Sciences › Medicine › Physiology (medical) › High Altitude and Hypoxia
- Keywords
- erythropoietin, liver, hepatectomy, hypoxia, nephrectomy, hypobaric hypoxia, plasma erythropoietin levels
- MeSH terms
- Adrenalectomy, Animals, Hypoxia, Castration, Erythropoiesis, Erythropoietin, Hepatectomy, Hydrocortisone, Liver, Nephrectomy, Polycythemia, Rats
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