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A clinical study of the lupus anticoagulant
Abstract
Eighty-three patients with circulating anticoagulants were studied at The New York Hospital. The lupus-type anticoagulant, an inhibitor of the prothrombin activator complex, was demonstrated in 58 patients. The inhibitor was identified using the blood and tissue thromboplastin inhibition tests. Inhibition by the lupus anticoagulant was augmented in 67% of these patients by a cofactor present in normal plasma. The lupus inhibitor was detected primarily because of an unsuspected abnormal coagulation test. One-half of the patients with the lupus-type anticoagulant did not have systemic lupus erythematosus.
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Cited by
Harris, E. N., Boey, M. L., Mackworth-Young, C. G., Gharavi, A. E., Patel, B. M., Loizou, S., & Hughes, G. R. V. (1983) · The Lancet · doi:10.1016/s0140-6736(83)91267-9 · Cited by 1,383
Guidelines on the investigation and management of antiphospholipid syndrome
Keeling, D., Mackie, I., Moore, G. W., Greer, I. A., Greaves, M., & British Committee for Standards in Haematology (2012) · British Journal of Haematology · doi:10.1111/j.1365-2141.2012.09037.x · Cited by 740
Boey, M. L., Colaco, C. B., Gharavi, A. E., Elkon, K. B., Loizou, S., & Hughes, G. R. (1983) · BMJ · doi:10.1136/bmj.287.6398.1021 · Cited by 508
Immunology and clinical importance of antiphospholipid antibodies
McNeil, H. P., Chesterman, C. N., & Krilis, S. A. (1991) · Advances in immunology · doi:10.1016/s0065-2776(08)60777-4 · Cited by 481
Finazzi, G., Brancaccio, V., Moia, M., Ciavarella, N., Mazzucconi, M. G., Schinco, P., Ruggeri, M., Pogliani, E. M., Gamba, G., Rossi, E., et al. (1996) · The American Journal of Medicine · doi:10.1016/s0002-9343(96)00060-5 · Cited by 427
Metadata
- Authors
- Schleider, M., Nachman, R., Jaffe, E., & Coleman, M.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 1976-10-01
- Volume
- 48
- Issue
- 4
- Pages
- 499-509
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W1546252777
- Cited by
- 470
- References
- 0
- FWCI
- 6.04
- Type
- journal article
- Language
- en
- Open access
- closed
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- Schleider, M., Nachman, R., Jaffe, E., & Coleman, M. (1976). A clinical study of the lupus anticoagulant. Blood. https://doi.org/10.1182/blood.v48.4.499.499
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
