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The factor VIII complex: structure and function
Abstract
Normal human plasma contains a complex of two proteins that are important in hemostasis and coagulation. The factor VIII procoagulant protein (antihemophilic factor) and the factor VIII-related protein (von Willebrand factor) are under separate genetic control, have distinct biochemical and immunologic properties, and have unique and essential physiologic functions. While the nature of their interaction and the details of the biochemical structures remain to be determined, the information now available permits a preliminary understanding of the molecular defects in hemophilia and von Willebrand's diseases.
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Cited by
Molecular Biology of Fibronectin
Hynes, R. (1985) · Annual Review of Cell Biology · doi:10.1146/annurev.cb.01.110185.000435 · Cited by 601
Gum, J. R., Hicks, J. W., Toribara, N. W., Rothe, E. M., Lagace, R. E., & Kim, Y. S. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)36620-7 · Cited by 273
Elevated Plasma Levels of Vwf:Ag in Hyperthyroidism are Mediated Through Beta-Adrenergic Receptors
Liu, L., Wang, X., Lin, Z., & Wu, H. (1993) · Endocrine Research · doi:10.3109/07435809309033019 · Cited by 34
Metadata
- Authors
- Hoyer, L.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 1981-07-01
- Volume
- 58
- Issue
- 1
- Pages
- 1-13
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W1480284744
- Cited by
- 415
- References
- 0
- FWCI
- 30.98
- Type
- journal article
- Language
- en
- Open access
- closed
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- Hoyer, L. (1981). The factor VIII complex: structure and function. Blood. https://doi.org/10.1182/blood.v58.1.1.1
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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