Elevated Plasma Levels of Vwf:Ag in Hyperthyroidism are Mediated Through Beta-Adrenergic Receptors
Abstract
Thyroid dysfunction influences the levels of Von Willebrand factor (VWF:Ag). Plasma VWF:Ag levels in 35 hyperthyroid patients were significantly elevated, which had a positive correlation with both T3 (Triiodothyronine) and T4 (Thyroxine) levels. A follow-up study of seven hyperthyroid patients undergoing anti-thyroid therapy showed that the elevated VWF:Ag levels returned to normal range with the normalization of thyroid function. On the other hand, after administration of 160 mg/day of propranolol, a specific blocker of beta-adrenergic receptors, to five hyperthyroid patients for twenty-eight days, plasma VWF:Ag levels returned to normal range, while T3, T4 levels remained high without significant alteration. These results demonstrated that the elevation of plasma VWF:Ag by thyroid hormone is mediated through beta-adrenergic receptors, which may be useful to further understand the physiological and pathological roles of thyroid hormone in the regulation of VWF:Ag levels.
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Excess thyroid hormone activity results in a procoagulant state, with increased VWF, FVIII, fibrinogen, and D-dimer in subclinical hyperthyroidism and elevations in fibrinogen, fibronectin, VWF, thrombomodulin, and PAI-1, with decreased t-PA in overt endogenous hyperthyroidism.
“Excess thyroid hormone activity results in a procoagulant state, with increased VWF, FVIII, fibrinogen, and D-dimer in subclinical hyperthyroidism and elevations in fibrinogen, fibronectin, VWF, thrombomodulin, and PAI-1, with decreased t-PA in overt, endogenous hyperthyroidism”
From Pharmacodynamic and Therapeutic Actions of Levothyroxine (2021) · cites this paper as [114]
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The influence of thyroid function on the coagulation system and its clinical consequences
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Pharmacodynamic and Therapeutic Actions of Levothyroxine
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- Authors
- Liu, L., Wang, X., Lin, Z., & Wu, H.
- Venue
- Endocrine Research
- Publisher
- Informa UK Limited
- Published
- 1993-01
- Volume
- 19
- Issue
- 2-3
- Pages
- 123-133
- ISSN
- 0743-5800 (ISSN-L)
- 1532-4206
- OpenAlex
- W2089905847
- Cited by
- 34
- References
- 20
- Citations by year
- 2023: 1 · 2022: 1 · 2021: 1 · 2020: 1 · 2019: 1 · 2018: 3 · 2016: 2 · 2013: 3 · 2012: 2
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Endocrine Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Hematology › Platelet Disorders and Treatments
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Blood properties and coagulation
- Keywords
- von Willebrand factor, hyperthyroidism, beta-adrenergic receptors, propranolol, thyroid hormones, triiodothyronine, thyroxine, plasma vWF levels
- MeSH terms
- Adult, Antigens, Female, Follow-Up Studies, Humans, Hyperthyroidism, Hypothyroidism, Male, Middle Aged, Receptors, Adrenergic, beta, von Willebrand Factor
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