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Cited by 431

The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.

Surface phenotype of Japanese adult T-cell leukemia cells characterized by monoclonal antibodies

Open access
Hattori, T, Uchiyama, T, Toibana, T, Takatsuki, K, Uchino, H·1981·Blood

Abstract

We studies the surface phenotype and the functional activities of leukemic cells from three patients with Japanese adult T-cell leukemic (ATL) using the panel of OK and anti-Tac monoclonal antibodies, which react with differentiation antigens and define functionally distinct T- cell subsets or activated and terminally differentiated T cells. The phenotype of ATL cells were determined to be OKT1+T3+T4+T10+T5-T8-Okla1- , although cells from two patients suppressed pokeweed mitogen (PWM) induced normal B-cell differentiation, and cells from all patients lacked helper activity in this system. In addition, after cultivation with PWM, ATL cells from all patients were reactive with anti-Tac monoclonal antibody, and cells from one patient were reactive with OKlal. These findings suggest that ATL cells arise from peripheral mature T-cell subsets and also suggest that the transition of surface phenotype of ATL cells to functionally mature and activated T cells occurs in culture.

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Crossref · 10.1182/blood.v58.3.645.645

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Metadata

Authors
Hattori, T., Uchiyama, T., Toibana, T., Takatsuki, K., & Uchino, H.
Venue
Blood
Published
1981-09-01
Volume
58
Issue
3
Pages
645-647
ISSN
  • 0006-4971 (ISSN-L)
  • 1528-0020
OpenAlex
W1552516114
Cited by
431
References
10
FWCI
12.86
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Surface phenotype of Japanese adult T-cell leukemia cells characterized by monoclonal antibodies. https://app.cochat.ai/papers/10.1182/blood.v58.3.645.645
The paper
Hattori, T., Uchiyama, T., Toibana, T., Takatsuki, K., & Uchino, H. (1981). Surface phenotype of Japanese adult T-cell leukemia cells characterized by monoclonal antibodies. Blood. https://doi.org/10.1182/blood.v58.3.645.645

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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