The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
beta 2-Glycoprotein I: a plasma inhibitor of the contact activation of the intrinsic blood coagulation pathway
Abstract
The general hypothesis for the biological function of beta 2- glycoprotein I is that it neutralizes all negatively charged macromolecules that might enter the bloodstream and diminishes unwanted activation of the blood coagulation. In the present study we report that beta 2-glycoprotein I inhibits the activation of the contact phase system of the intrinsic pathway of blood coagulation. Activation was accomplished by an ellagic acid-phospholipid suspension (Cephotest) and measured by the appearance of amidolytic activity using the chromogenic substrate H-D-Pro-Phe-Arg-p-nitroanilide (S-2302). This inhibitory effect of beta 2-glycoprotein I was observed both when Cephotest was preincubated with beta 2-glycoprotein I and when the amount of beta 2- glycoprotein I in plasma was increased by addition of beta 2- glycoprotein I to either normal or beta 2-glycoprotein I-deficient plasma. The inhibitory effect of beta 2-glycoprotein I on the contact phase activation could be one of the physiological functions of this protein.
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Cites
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Role of surface in surface-dependent activation of Hageman factor (blood coagulation Factor XII)
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β2-glycoprotein-I (apolipoprotein H) interactions with phospholipid vesicles
Wurm, H. (1984) · International Journal of Biochemistry · doi:10.1016/0020-711x(84)90168-x · Cited by 234
The binding of β2‐glycoprotein‐I to human serum lipoproteins: Distribution among density fractions
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Cited by
McNeil, H. P., Simpson, R. J., Chesterman, C. N., & Krilis, S. A. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.11.4120 · Cited by 1,595
Immunology and clinical importance of antiphospholipid antibodies
McNeil, H. P., Chesterman, C. N., & Krilis, S. A. (1991) · Advances in immunology · doi:10.1016/s0065-2776(08)60777-4 · Cited by 481
Immunology of the antiphospholipid antibody syndrome
Roubey, R. A. S. (1996) · Arthritis & Rheumatism · doi:10.1002/art.1780390903 · Cited by 302
Platelet microparticles: a wide-angle perspective
Horstman, L. L., & Ahn, Y. S. (1999) · Critical Reviews in Oncology/Hematology · doi:10.1016/s1040-8428(98)00044-4 · Cited by 300
Papa, N. D., Guidali, L., Sala, A., Buccellati, C., Khamashta, M. A., Ichikawa, K., Koike, T., Balestrieri, G., Tincani, A., Hughes, G. R. V., et al. (1997) · Arthritis & Rheumatism · doi:10.1002/art.1780400322 · Cited by 289
Metadata
- Authors
- Schousboe, I.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 1985-11-01
- Volume
- 66
- Issue
- 5
- Pages
- 1086-1091
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W1766730806
- Cited by
- 366
- References
- 19
- FWCI
- 3.22
- Type
- journal article
- Language
- en
- Open access
- closed
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- Schousboe, I. (1985). beta 2-Glycoprotein I: a plasma inhibitor of the contact activation of the intrinsic blood coagulation pathway. Blood. https://doi.org/10.1182/blood.v66.5.1086.1086
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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