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Cited by 258

The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.

Acute nonlymphocytic leukemia following etoposide and cisplatin combination chemotherapy for advanced non-small-cell carcinoma of the lung

Ratain, MJ, Kaminer, LS, Bitran, JD, Larson, RA, Le Beau, MM, Skosey, C, Purl, S, Hoffman, PC, Wade, J, Vardiman, JW·1987·Blood
DOI 10.1182/blood.v70.5.1412.1412
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Abstract

Combination chemotherapy is frequently used in the therapy of advanced non-small-cell lung cancer (NSCLC), but late complications are rarely recognized because of the short survival of most patients. Of 119 patients with advanced NSCLC treated with cisplatin and other drugs, four patients developed acute nonlymphocytic leukemia (ANLL). All four patients received etoposide and cisplatin with or without vindesine. Leukemia was diagnosed at 13, 19, 28, and 35 months after start of treatment. Three patients had morphologic and/or cytogenetic features of acute leukemia with significant monoblastic involvement; the fourth patient had trilineage dysplasia and cytogenetic abnormalities more commonly associated with therapy-related leukemia. Detailed analysis of the subgroup who survived longer than 1 year (24 patients) suggests that high cumulative doses of etoposide are leukemogenic; the median etoposide dose was 6,795 mg/m2 (first year only) in the four leukemic patients compared with 3,025 mg/m2 in the 20 nonleukemic patients (P less than .01). The rate of ANLL was 0.30 per person-year after the first year (95% confidence limits 0.11 to 0.90), with a cumulative risk of 15% +/- 11% at 2 years, and 44% +/- 24% at 2.5 years. We conclude that high doses of etoposide are potentially leukemogenic, and can induce a syndrome with features of acute monoblastic leukemia de novo that is distinct from other secondary leukemias.

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Metadata

Authors
Ratain, M., Kaminer, L., Bitran, J., Larson, R., Le Beau, M., Skosey, C., Purl, S., Hoffman, P., Wade, J., & Vardiman, J.
Venue
Blood
Publisher
American Society of Hematology
Published
1987-11-01
Volume
70
Issue
5
Pages
1412-1417
ISSN
  • 0006-4971 (ISSN-L)
  • 1528-0020
DOI
10.1182/blood.v70.5.1412.1412
OpenAlex
W33382804
Cited by
258
References
14
FWCI
3.53
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Acute nonlymphocytic leukemia following etoposide and cisplatin combination chemotherapy for advanced non-small-cell carcinoma of the lung. https://app.cochat.ai/papers/10.1182/blood.v70.5.1412.1412
The paper
Ratain, M., Kaminer, L., Bitran, J., Larson, R., Le Beau, M., Skosey, C., Purl, S., Hoffman, P., Wade, J., & Vardiman, J. (1987). Acute nonlymphocytic leukemia following etoposide and cisplatin combination chemotherapy for advanced non-small-cell carcinoma of the lung. Blood. https://doi.org/10.1182/blood.v70.5.1412.1412

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.