The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Wegener's granulomatosis autoantigen is a novel neutrophil serine proteinase [see comments]
Open accessAbstract
Circulating IgG autoantibodies that produce cytoplasmic immunofluorescence staining of ethanol-fixed normal neutrophils have recently been found in a large percentage of patients with active Wegener's granulomatosis. Such autoantibodies are rarely found in other diseases and are therefore virtually diagnostic of Wegener's granulomatosis. The nature of the neutrophil antigen defined by these autoantibodies is controversial and the roles of the antigen and/or autoantibodies in the pathogenesis of Wegener's granulomatosis are unknown. We studied serum samples that produce the cytoplasmic pattern of staining from 10 patients with a diagnosis of Wegener's granulomatosis. By Western blot analysis, all 10 sera reacted with a 29- Kd neutrophil protein (p29). We generated a mouse monoclonal antibody directed against this antigen. The monoclonal antibody produced the same immunofluorescence staining pattern as the serum autoantibodies and was used to affinity-purify p29. The purified antigen had a novel N- terminal sequence homologous to members of the serine proteinase family and bound to radiolabeled diisopropyl fluorophosphate (DFP). We conclude that the neutrophil antigen responsible for the cytoplasmic staining pattern produced by autoantibodies in patients with active Wegener's granulomatosis is a distinctive serine proteinase.
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Cited by
Differential Diagnosis of Glomerular Disease: A Systematic and Inclusive Approach
Hebert, L. A., Parikh, S., Prosek, J., Nadasdy, T., & Rovin, B. H. (2013) · American Journal of Nephrology · doi:10.1159/000354390 · Cited by 4,376
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Anti-neutrophil cytoplasmic antibodies: Current diagnostic and pathophysiological potential
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Falk, R. J., Hogan, S., Carey, T. S., Jennette, J. C., & The Glomerular Disease Collaborative Network (1990) · Annals of Internal Medicine · doi:10.7326/0003-4819-113-9-656 · Cited by 391
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Metadata
- Authors
- Niles, J., McCluskey, R., Ahmad, M., & Arnaout, M.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 1989-11-01
- Volume
- 74
- Issue
- 6
- Pages
- 1888-1893
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W2902766594
- Cited by
- 409
- References
- 17
- FWCI
- 39.09
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Niles, J., McCluskey, R., Ahmad, M., & Arnaout, M. (1989). Wegener's granulomatosis autoantigen is a novel neutrophil serine proteinase [see comments]. Blood. https://doi.org/10.1182/blood.v74.6.1888.1888
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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