The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
Limited prognostic value of changes in antineutrophil cytoplasmic antibody titer in patients with wegener's granulomatosis
Abstract
Objective. To assess the correlation and prognostic value of antineutrophil cytoplasmic antibody (cANCA) titers with disease activity in patients with Wegener's granulomatosis (WG). Methods. One hundred six patients with WG had serum ANCA determinations; 72 had serial titers obtained routinely at 1–3‐month intervals. One hundred twelve subjects (19 of whom were healthy donors) served as controls. All serum samples were tested for cANCA by an indirect immunofluorescence technique. A prospective analysis of disease activity and cANCA values was performed. Disease activity was assessed according to clinical, laboratory, radiographic, and histopathologic findings. Results. Positivity for cANCA was a sensitive (88%) marker of active WG. However, changes in serial titers temporally correlated with a change in disease status in only 64% of patients. Furthermore, an increase in the cANCA titer preceded clinical exacerbation of disease in only 24% of patients who had been in remission or had low‐grade, smoldering disease. Conclusion. A rise in cANCA titer alone should not be considered adequate evidence of an impending clinical exacerbation, and therefore does not justify initiating or increasing immunosuppressive therapy.
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Cites
Wegener Granulomatosis: An Analysis of 158 Patients
Hoffman, G. S., Kerr, G. S., Leavitt, R. Y., Hallahan, C. W., Lebovics, R. S., Travis, W. D., Rottem, M., & Fauci, A. S. (1992) · Annals of Internal Medicine · doi:10.7326/0003-4819-116-6-488 · Cited by 2,857
Self-citationFAUCI, A. S., HAYNES, B. F., KATZ, P., & WOLFF, S. M. (1983) · Annals of Internal Medicine · doi:10.7326/0003-4819-98-1-76 · Cited by 2,001
Self-citationVan Der Woude, F. J., Lobatto, S., Permin, H., Van Der Giessen, M., Rasmussen, N., Wiik, A., Van Es, L. A., Van Der Hem, G. K., & The, T. H. (1985) · The Lancet · doi:10.1016/s0140-6736(85)91147-x · Cited by 1,885
Segmental necrotising glomerulonephritis with antineutrophil antibody: possible arbovirus aetiology?
Davies, D. J., Moran, J. E., Niall, J. F., & Ryan, G. B. (1982) · BMJ · doi:10.1136/bmj.285.6342.606 · Cited by 864
WEGENERʼS GRANULOMATOSIS: STUDIES IN EIGHTEEN PATIENTS AND A REVIEW OF THE LITERATURE
FAUCI, A. S., & WOLFF, S. M. (1973) · Medicine · doi:10.1097/00005792-197311000-00002 · Cited by 788
Self-citationWegener's granulomatosis: pathology and review of the literature.
Godman, G. C., & Churg, J. (1954) · PubMed · Cited by 593
Association Between Active Wegener's Granulomatosis and Anticytoplasmic Antibodies
Tervaert, J. W. C. (1989) · Archives of Internal Medicine · doi:10.1001/archinte.149.11.2461 · Cited by 517
Goldschmeding, R., van der Schoot, C. E., ten Bokkel Huinink, D., Hack, C. E., van den Ende, M. E., Kallenberg, C. G., & von dem Borne, A. E. (1989) · Journal of Clinical Investigation · doi:10.1172/jci114335 · Cited by 432
COHENTERVAERT, J. (1990) · The Lancet · doi:10.1016/0140-6736(90)92205-v · Cited by 411
Wegener's granulomatosis autoantigen is a novel neutrophil serine proteinase [see comments]
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Cited by
Boomsma, M. M., Stegeman, C. A., Van Der Leij, M. J., Oost, W., Hermans, J., Kallenberg, C. G. M., Limburg, P. C., & Tervaert, J. W. C. (2000) · Arthritis & Rheumatism · doi:10.1002/1529-0131(200009)43:9<2025::aid-anr13>3.0.co;2-o · Cited by 434
Anti-neutrophil cytoplasmic antibodies: Current diagnostic and pathophysiological potential
Kallenberg, C. G. M., Brouwer, E., Weening, J. J., & Cohen Tervaert, J. W. (1994) · Kidney International · doi:10.1038/ki.1994.239 · Cited by 408
Tomasson, G., Grayson, P. C., Mahr, A. D., LaValley, M., & Merkel, P. A. (2012) · Rheumatology · doi:10.1093/rheumatology/ker280 · Cited by 353
An analysis of forty‐two wegener's granulomatosis patients treated with methotrexate and prednisone
Sneller, M. C., Hoffman, G. S., Talar‐Williams, C., Kerr, G. S., Hallahan, C. W., & Fauci, A. S. (1995) · Arthritis & Rheumatism · doi:10.1002/art.1780380505 · Cited by 265
Self-citationUse of Highly Sensitive C-Reactive Protein for Followup of Wegener’s Granulomatosis
KÄLSCH, A.-I., CSERNOK, E., MÜNCH, D., BIRCK, R., YARD, B. A., GROSS, W., KÄLSCH, T., & SCHMITT, W. H. (2010) · The Journal of Rheumatology · doi:10.3899/jrheum.100302 · Cited by 44
Metadata
- Authors
- Kerr, G. S., Fleisher, T. A., Hallahan, C. W., Leavitt, R. Y., Fauci, A. S., & Hoffman, G. S.
- Venue
- Arthritis & Rheumatism
- Publisher
- Wiley
- Published
- 1993-03
- Volume
- 36
- Issue
- 3
- Pages
- 365-371
- ISSN
- 0004-3591 (ISSN-L)
- 1529-0131
- OpenAlex
- W2015359612
- Cited by
- 298
- References
- 15
- FWCI
- 19.21
- Type
- journal article
- Language
- en
- Open access
- closed
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