The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
T-cell depletion of HLA-identical transplants in leukemia
Abstract
We analyzed the effects of T-cell depletion on the outcome of HLA- identical sibling bone marrow transplants for leukemia by comparing 731 T-cell-depleted transplants with 2,480 non-T-cell-depleted transplants. T-cell depletion decreased acute graft-versus-host disease (GVHD) (relative risk [RR] 0.45; P less than .0001) and chronic (GVHD) (RR 0.56; P less than .0001). However, it increased graft failure (RR 9.29; P less than .0001). Leukemia relapse also was increased. In first remission acute leukemia or chronic phase chronic myelogenous leukemia, leukemia relapse was 2.75 times more likely after T-cell-depleted transplants (P less than .0001). T-cell depletion increased the risk of treatment failure (RR 1.35; P less than .0003) and decreased leukemia- free survival. We also studied controllable variables associated with outcome of T-cell-depleted transplants. The unique findings were that among recipients of T-cell-depleted transplants for early leukemia, radiation doses greater than or equal to 11 Gy (RR 0.54; P less than .01), dose rates greater than 14 cGy/min (RR 0.56; P less than .002), and additional posttransplant immune suppression with cyclosporine alone (RR 0.53; P less than .0006) or cyclosporine plus methotrexate (RR 0.36; P less than .01) were associated with fewer treatment failures. Use of monoclonal antibodies rather than physical techniques for T-cell depletion (RR 2.01; P less than .03) and fractionated radiation (RR 1.69; P less than .05) were associated with increased treatment failure and lower leukemia-free survival. These data may be useful in designing strategies to improve results of T-cell-depleted transplants.
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Citations
Cites
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Cited by
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Metadata
- Authors
- Marmont, A., Horowitz, M., Gale, R., Sobocinski, K., Ash, R., van Bekkum, D., Champlin, R., Dicke, K., Goldman, J., & Good, R.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 1991-10-15
- Volume
- 78
- Issue
- 8
- Pages
- 2120-2130
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W2149131140
- Cited by
- 745
- References
- 16
- FWCI
- 12.20
- Type
- journal article
- Language
- en
- Open access
- closed
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- Marmont, A., Horowitz, M., Gale, R., Sobocinski, K., Ash, R., van Bekkum, D., Champlin, R., Dicke, K., Goldman, J., & Good, R. (1991). T-cell depletion of HLA-identical transplants in leukemia. Blood. https://doi.org/10.1182/blood.v78.8.2120.2120
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
