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Cited by 137Hepatitis C virus researchHIV, Drug Use, Sexual RiskHemophilia Treatment and Research

The low risk of hepatitis C virus transmission among sexual partners of hepatitis C-infected hemophilic males: an international, multicenter study.

Open access
Brettler, DB, Mannucci, PM, Gringeri, A, Rasko, JE, Forsberg, AD, Rumi, MG, Garsia, RJ, Rickard, KA +1 more·1992·Blood
DOI 10.1182/blood.v80.2.540.540
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Abstract

To study the transmission rate of hepatitis C virus (HCV) in the female sexual partners of antibody-positive hemophilic males, 106 partners from three hemophilia centers located in Europe, America, and Australia were tested for HCV seropositivity using a first-generation enzyme-linked immunosorbent assay (ELISA-1) and, subsequently, a second-generation ELISA (ELISA-2) and a supplemental recombinant immunoblot assay. Additionally, the cohort was tested for the presence of antibody to the human immunodeficiency virus type-1 and hepatitis B virus markers. No female partner was HCV antibody-positive using the ELISA-1 test, whereas five were seropositive by the ELISA-2 test. Three of these five female partners were seropositive on the supplemental test, the remaining two having indeterminate results, for an overall prevalence of 2.7%. Thus, even with the use of sensitive testing, the prevalence of HCV infection remains low in this cohort, showing that the efficiency of heterosexual transmission of HCV is poor.

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Crossref · 10.1182/blood.v80.2.540.540

Cites

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  • Risk of HCV infection increases commensurate with increasing numbers of sex partners among heterosexual persons and MSM with HIV infection, especially if their partners are also coinfected with HIV.

    “Certain studies have revealed that risk increases commensurate with increasing numbers of sex partners among heterosexual persons (1337,1338,1351–1353) and MSM with HIV infection (1349,1354–1357), especially if their partners are also coinfected with HIV (237,1340,1354–1356,1358).”

    From Sexually Transmitted Infections Treatment Guidelines, 2021 (2021) · cites this paper as [1337]

    The source addresses HIV coinfection but reaches the opposite conclusion for its cohort. In the Discussion, the authors state that they could not show an association between HIV/HCV coinfection in hemophilic men and HCV transmission to their female partners; Table 3 likewise reports no significant difference. The study does not assess whether risk rises with the number of sex partners. (LLM, conf=0.88)

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  • Studies have reported either no or minimally increased rates of HCV infection among partners of persons with HCV infection compared with partners of those without HCV.

    “Studies of HCV transmission between heterosexual couples and MSM have yielded mixed results; however, studies have reported either no or minimally increased rates of HCV infection among partners of persons with HCV infection compared with partners of those without HCV (1334,1336–1338).”

    From Sexually Transmitted Infections Treatment Guidelines, 2021 (2021) · cites this paper as [1337]

    The Discussion reports HCV infection in 2.7% of female partners of HCV-infected hemophilic men and concludes that heterosexual transmission was inefficient. The study did not compare those partners with partners of people without HCV; its reported comparison is with blood donors, whose prevalence was four to six times lower. Thus it supports the low-rate finding, but not the claim's specified partner-to-partner comparison. (LLM, conf=0.86)

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Research works printed but not linked: 2

  1. Rutter P, Rykaczewski C, McGuire MA, OBrien TA, Tupper BL, h u b P Hepatitis C antibody testing experience in a large regional blood center. Second International Symposium on HCV, Los Angeles, CA, November 8-9,1990, program (abstr B36)
  2. Operskalski EA Comparison of HCV with HBV infection among sexual and non sexual household contacts of persons with congenital clotting disorders. Second International Symposium on HCV, Los Angeles, CA, November 8-9,1990, program (abstr 80

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Authors
Brettler, D., Mannucci, P., Gringeri, A., Rasko, J., Forsberg, A., Rumi, M., Garsia, R., Rickard, K., & Colombo, M.
Affiliations
Department of Medicine, Medical Center of Central Massachusetts, Worcester 01605.
ORCID
Venue
Blood
Publisher
American Society of Hematology
Published
1992-07-15
Volume
80
Issue
2
Pages
540-543
ISSN
  • 0006-4971 (ISSN-L)
  • 1528-0020
DOI
10.1182/blood.v80.2.540.540
OpenAlex
W175273854
Cited by
137
References
24
Citations by year
2024: 1 · 2022: 1 · 2021: 1 · 2017: 2 · 2016: 1 · 2015: 2 · 2014: 1 · 2013: 4 · 2012: 1
FWCI
8.20
Type
journal article
Language
en
Open access
Locations
  • Blood (publishedVersion)
  • PubMed (publishedVersion)
  • The Journal of the American Medical Association (JAMA) Network (American Medical Association) (submittedVersion)
Funders
Centers for Disease Control and Prevention (MCI-252002-01)
Topics
  • Health Sciences › Medicine › Hepatology › Hepatitis C virus research
  • Health Sciences › Medicine › Epidemiology › HIV, Drug Use, Sexual Risk
  • Health Sciences › Medicine › Hematology › Hemophilia Treatment and Research
Keywords
hepatitis C virus, HCV transmission, hemophilia, female sexual partners, heterosexual transmission, HCV seroprevalence, HCV antibody testing, recombinant immunoblot assay, HIV-1, hepatitis B virus
MeSH terms
Enzyme-Linked Immunosorbent Assay, Female, Hemophilia A, Hepatitis Antibodies, Hepatitis C, HIV Seropositivity, Humans, Male, Risk Factors, Sexual Behavior, HIV Antibodies, Transfusion Reaction

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