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Cited by 310Hepatitis C virus researchHelicobacter pylori-related gastroenterology studiesHepatitis Viruses Studies and Epidemiology

Lack of evidence of sexual transmission of hepatitis C among monogamous couples: results of a 10-year prospective follow-up study.

Vandelli, Carmen, Renzo, Francesco, Romano, Luisa, Tisminetzky, Sergio, De Palma, Marisa, Stroffolini, Tommaso, Ventura, Ezio, Zanetti, Alessandro·2004·The American Journal of Gastroenterology
DOI 10.1111/j.1572-0241.2004.04150.x
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Abstract

The risk of sexual transmission of hepatitis C virus (HCV) infection was evaluated among 895 monogamous heterosexual partners of HCV chronically infected individuals in a long-term prospective study, which provided a follow-up period of 8,060 person-years. Seven hundred and seventy-six (86.7%) spouses were followed for 10 yr, corresponding to 7,760 person-years of observation. One hundred and nineteen (13.3%) spouses (69 whose infected partners cleared the virus following treatment and 50 who ended their relationship or were lost at follow-up) contributed an additional 300 person-years. All couples denied practicing anal intercourse or sex during menstruation, as well as condom use. The average weekly rate of sexual intercourse was 1.8. Three HCV infections were observed during follow-up corresponding to an incidence rate of 0.37 per 1,000 person-years. However, the infecting HCV genotype in one spouse (2a) was different from that of the partner (1b), clearly excluding sexual transmission. The remaining two couples had concordant genotypes, but sequence analysis of the NS5b region of the HCV genome, coupled with phylogenetic analysis showed that the corresponding partners carried different viral isolates, again excluding the possibility of intraspousal transmission of HCV. Our data indicate that the risk of sexual transmission of HCV within heterosexual monogamous couples is extremely low or even null. No general recommendations for condom use seem required for individuals in monogamous partnerships with HCV-infected partners.

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Crossref · 10.1111/j.1572-0241.2004.04150.x

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  • Incident HCV has not been demonstrated to occur among heterosexual couples followed over time.

    “Because incident HCV has not been demonstrated to occur among heterosexual couples followed over time (1334,1371–1373), condom use might not be necessary in such circumstances.”

    From Sexually Transmitted Infections Treatment Guidelines, 2021 (2021) · cites this paper as [1373]

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Authors
Vandelli, C., Renzo, F., Romano, L., Tisminetzky, S., De Palma, M., Stroffolini, T., Ventura, E., & Zanetti, A.
Affiliations
University of Modena and Reggio Emilia (IT)
Corresponding author
Vandelli, Carmen
ORCID
Venue
The American Journal of Gastroenterology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2004-05
Volume
99
Issue
5
Pages
855-859
ISSN
  • 0002-9270 (ISSN-L)
  • 1572-0241
DOI
10.1111/j.1572-0241.2004.04150.x
OpenAlex
W2156891291
Cited by
310
References
37
Citations by year
2026: 4 · 2024: 5 · 2023: 4 · 2022: 3 · 2021: 4 · 2020: 5 · 2019: 13 · 2018: 10 · 2017: 10 · 2016: 24 · 2015: 17 · 2014: 16 · 2013: 24 · 2012: 19
FWCI
12.56
Type
journal article
Language
en
Open access
closed
Locations
  • The American Journal of Gastroenterology (publishedVersion)
  • PubMed (publishedVersion)
  • IRIS UNIMORE (University of Modena and Reggio Emilia) (submittedVersion)
Topics
  • Health Sciences › Medicine › Hepatology › Hepatitis C virus research
  • Health Sciences › Medicine › Surgery › Helicobacter pylori-related gastroenterology studies
  • Health Sciences › Medicine › Hepatology › Hepatitis Viruses Studies and Epidemiology
Keywords
hepatitis C virus, sexual transmission, monogamous couples, spouses, chronic hepatitis C, HCV genotypes, NS5B region, phylogenetic analysis, viral clearance, condom use, transmission risk
MeSH terms
Adult, Base Sequence, DNA, Viral, Family Characteristics, Female, Humans, Italy, Male, Middle Aged, Molecular Sequence Data, Prospective Studies, Sexually Transmitted Diseases, Viral, Cohort Studies, Prevalence, Polymerase Chain Reaction, Hepacivirus, Age Distribution, Sex Distribution, Risk Assessment, Hepatitis C, Chronic, Heterosexuality

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