The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
Quantitation of activated factor VII levels in plasma using a tissue factor mutant selectively deficient in promoting factor VII activation
Open accessAbstract
Although the majority of factor VII (FVII) circulates in the zymogen form, low levels of activated factor VII (FVIIa) have been postulated to exist in plasma and to serve a priming function for triggering of the clotting cascade. However, direct measurement of plasma FVIIa has not previously been possible. We have quantified plasma FVIIa levels using a novel, highly sensitive assay that is free from interference by FVII. Specificity of this clot-based assay results from the use of a mutant tissue factor that is selectively deficient in promoting FVII activation, but retains FVIIa cofactor function. In normal adults, FVIIa was found to be present in plasma (mean: 3.6 ng/mL) with considerable variation between individuals (range: 0.5 to 8.4 ng/mL). FVIIa levels were only loosely correlated with FVII coagulant activity, but were elevated in pregnancy and reduced with oral anticoagulant therapy. Incubation of plasma on ice in glass containers (cold activation) resulted in substantial FVIIa generation. Measurement of plasma forms of factor VII is of potential clinical importance because elevated FVII coagulant activity has been implicated as a significant risk predictor for ischemic heart disease. Clinically, this new assay will now permit direct assessment of the role of plasma FVIIa in thrombotic disorders.
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HÆMOSTATIC FUNCTION AND CARDIOVASCULAR DEATH: EARLY RESULTS OF A PROSPECTIVE STUDY
Meade, T. W., Chakrabarti, R., Haines, A. P., North, W. R. S., Stirling, Y., Thompson, S. G., & Brozović, M. (1980) · The Lancet · doi:10.1016/s0140-6736(80)91498-1 · Cited by 690
Tissue factor and hemostasis [published erratum appears in Blood 1988 Apr;71(4):1178]
Nemerson, Y. (1988) · Blood · doi:10.1182/blood.v71.1.1.1 · Cited by 682
Phospholipid vesicle formation and transmembrane protein incorporation using octyl glucoside
Mimms, L. T., Zampighi, G., Nozaki, Y., Tanford, C., & Reynolds, J. A. (1981) · Biochemistry · doi:10.1021/bi00507a028 · Cited by 679
Bauer, K., & Rosenberg, R. (1987) · Blood · doi:10.1182/blood.v70.2.343.343 · Cited by 389
Population correlates of plasma fibrinogen and factor VII, putative cardiovascular risk factors
FOLSOM, A., WU, K., DAVIS, C., CONLAN, M., SORLIE, P., & SZKLO, M. (1991) · Atherosclerosis · doi:10.1016/0021-9150(91)90167-2 · Cited by 321
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Self-citationActivation of Human Factor VII in Plasma and in Purified Systems
Seligsohn, U., Østerud, B., Brown, S. F., Griffin, J. H., & Rapaport, S. I. (1979) · Journal of Clinical Investigation · doi:10.1172/jci109543 · Cited by 164
Measurement of basal levels of factor VIIa in hemophilia A and B patients [see comments]
Wildgoose, P., Nemerson, Y., Hansen, L., Nielsen, F., Glazer, S., & Hedner, U. (1992) · Blood · doi:10.1182/blood.v80.1.25.25 · Cited by 161
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Cited by
Mechanisms of Thrombus Formation
Furie, B., & Furie, B. C. (2008) · New England Journal of Medicine · doi:10.1056/nejmra0801082 · Cited by 1,926
Gorbet, M. B., & Sefton, M. V. (2004) · Biomaterials · doi:10.1016/j.biomaterials.2004.01.023 · Cited by 1,347
Patel, P., Mendall, M. A., Carrington, D., Strachan, D. P., Leatham, E., Molineaux, N., Levy, J., Blakeston, C., Seymour, C. A., Camm, A. J., et al. (1995) · BMJ · doi:10.1136/bmj.311.7007.711 · Cited by 592
How it all starts: Initiation of the clotting cascade
Smith, S. A., Travers, R. J., & Morrissey, J. H. (2015) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.3109/10409238.2015.1050550 · Cited by 529
Self-citationBiochemistry and Physiology of Blood Coagulation
Mann, K. (1999) · Thrombosis and Haemostasis · doi:10.1055/s-0037-1615780 · Cited by 462
Metadata
- Authors
- Morrissey, J., Macik, B., Neuenschwander, P., & Comp, P.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 1993-02-01
- Volume
- 81
- Issue
- 3
- Pages
- 734-744
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W167520159
- Cited by
- 512
- References
- 20
- FWCI
- 12.79
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Morrissey, J., Macik, B., Neuenschwander, P., & Comp, P. (1993). Quantitation of activated factor VII levels in plasma using a tissue factor mutant selectively deficient in promoting factor VII activation. Blood. https://doi.org/10.1182/blood.v81.3.734.734
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
