The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Human FLT3/FLK2 gene: cDNA cloning and expression in hematopoietic cells
Abstract
The human FLT3 cDNA was cloned from a pre-B cell line and characterized. The deduced amino acid sequence shows that FLT3 codes for a receptor-type tyrosine kinase of 993 residues, presenting a strong similarity with the corresponding mouse FLT3/FLK2 protein as well as with the receptors for colony-stimulating factor 1 (CSF1R/FMS) and steel locus factor (SLFR/KIT). An analysis of the expression of the gene using amplification of reverse transcribed FLT3 mRNA by polymerase chain reaction shows that FLT3 is expressed in various lymphohematopoietic cells and tissues, including a series of immature cell lines and leukemias of lymphocytic origin.
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Citations
Cites
The dominant-white spotting (W) locus of the mouse encodes the c-kit proto-oncogene
Geissler, E. N., Ryan, M. A., & Housman, D. E. (1988) · Cell · doi:10.1016/0092-8674(88)90020-7 · Cited by 1,287
Do the poly(A) tail and 3’ untranslated region control mRNA translation?
Jackson, R. J., & Standart, N. (1990) · Cell · doi:10.1016/0092-8674(90)90235-7 · Cited by 590
Colony-stimulating factor-1 receptor
Sherr, C. (1990) · Blood · doi:10.1182/blood.v75.1.1.bloodjournal7511 · Cited by 353
Cited by
The role of FLT3 in haematopoietic malignancies
Stirewalt, D. L., & Radich, J. P. (2003) · Nature Reviews Cancer · doi:10.1038/nrc1169 · Cited by 865
Prognostic implication of FLT3 and N-RAS gene mutations in acute myeloid leukemia.
Kiyoi, H., Naoe, T., Nakano, Y., Yokota, S., Minami, S., Miyawaki, S., Asou, N., Kuriyama, K., Jinnai, I., Shimazaki, C., et al. (1999) · PubMed · doi:10.1182/blood.v93.9.3074 · Cited by 757
c-kit Ligand and Flt3 Ligand: Stem/Progenitor Cell Factors With Overlapping Yet Distinct Activities
Lyman, S. D., & Jacobsen, S. E. W. (1998) · Blood · doi:10.1182/blood.v91.4.1101 · Cited by 696
Hayakawa, F., Towatari, M., Kiyoi, H., Tanimoto, M., Kitamura, T., Saito, H., & Naoe, T. (2000) · Oncogene · doi:10.1038/sj.onc.1203354 · Cited by 579
Identification of novel FLT‐3 Asp835 mutations in adult acute myeloid leukaemia
Abu‐Duhier, F. M., Goodeve, A. C., Wilson, G. A., Care, R. S., Peake, I. R., & Reilly, J. T. (2001) · British Journal of Haematology · doi:10.1046/j.1365-2141.2001.02850.x · Cited by 388
Metadata
- Authors
- Rosnet, O., Schiff, C., Pebusque, M., Marchetto, S., Tonnelle, C., Toiron, Y., Birg, F., & Birnbaum, D.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 1993-08-15
- Volume
- 82
- Issue
- 4
- Pages
- 1110-1119
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W148052780
- Cited by
- 349
- References
- 3
- FWCI
- 6.72
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Human FLT3/FLK2 gene: cDNA cloning and expression in hematopoietic cells. https://app.cochat.ai/papers/10.1182/blood.v82.4.1110.1110
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- Rosnet, O., Schiff, C., Pebusque, M., Marchetto, S., Tonnelle, C., Toiron, Y., Birg, F., & Birnbaum, D. (1993). Human FLT3/FLK2 gene: cDNA cloning and expression in hematopoietic cells. Blood. https://doi.org/10.1182/blood.v82.4.1110.1110
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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