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Cited by 587

The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.

Fusarium, a Significant Emerging Pathogen in Patients With Hematologic Malignancy: Ten Years' Experience at a Cancer Center and Implications for Management

Open access
Boutati, Eleni I., Anaissie, Elias J.·1997·Blood

Abstract

Despite increasing reports of life-threatening Fusarium infections, little is known about its pathogenesis and management. To evaluate the epidemiology, clinicopathologic features, and outcome of invasive fusariosis in patients with hematologic cancer, we conducted a retrospective study of invasive fusarial infections in patients with hematologic malignancy treated at a referral cancer center over a 10-year period (1986 to 1995), as well as a literature review. Forty patients with disseminated and three patients with invasive lung infection were included in the analysis. All patients were immunocompromised. The infection occurred in three patients postengraftment following bone marrow transplantation. All patients were diagnosed antemortem. Thirteen patients responded to therapy, but the infection relapsed in two of them. Response was associated with granulocyte transfusions, amphotericin B lipid formulations (four patients each), and an investigational triazole (two patients). Resolution of infection was only seen in patients who ultimately recovered from myelosuppression. Portal of entry was the skin (33%), the sinopulmonary tree (30%), and unknown (37%). Fusarium causes serious morbidity and mortality, and may mimic aspergillosis. The infection seems to respond to newer therapeutic approaches, but only in patients with ultimate recovery from myelosuppression, and it may relapse if neutropenia recurs.

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Metadata

Authors
Boutati, E. I., & Anaissie, E. J.
Venue
Blood
Published
1997-08-01
Volume
90
Issue
3
Pages
999-1008
ISSN
  • 0006-4971 (ISSN-L)
  • 1528-0020
OpenAlex
W2168916502
Cited by
587
References
36
FWCI
9.71
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Fusarium, a Significant Emerging Pathogen in Patients With Hematologic Malignancy: Ten Years' Experience at a Cancer Center and Implications for Management. https://app.cochat.ai/papers/10.1182/blood.v90.3.999
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Boutati, E. I., & Anaissie, E. J. (1997). Fusarium, a Significant Emerging Pathogen in Patients With Hematologic Malignancy: Ten Years' Experience at a Cancer Center and Implications for Management. Blood. https://doi.org/10.1182/blood.v90.3.999

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