The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Voriconazole in the treatment of aspergillosis, scedosporiosis and other invasive fungal infections in children
Abstract
Objective To describe the safety and efficacy of voriconazole in children treated within the compassionate release program. Methods Children received voriconazole on a compassionate basis for treatment of an invasive fungal infection if they were refractory to or intolerant of conventional antifungal therapy. Voriconazole was administered as a loading dose of 6 mg/kg every 12 h i.v. on Day 1 followed by 4 mg/kg every 12 h i.v. thereafter. When feasible the route of administration of voriconazole was changed from i.v. to oral (100 or 200 mg twice a day for patients weighing or = 40 kg, respectively). Outcome was assessed by investigators at the end of therapy or at the last visit as success (complete or partial response), stable infection, or failure, based on protocol-defined criteria. Results Sixty-nine children (ages 9 months to 15 years; median, 7 years) received voriconazole; 58 had a proven or probable fungal infection. Among these 58 patients 27 had hematologic malignancies and 13 had chronic granulomatous disease as the most frequent underlying conditions. Forty-two patients had aspergillosis, 8 had scedosporiosis, 4 had invasive candidiasis and 4 had other invasive fungal infections. The median duration of voriconazole therapy was 93 days. At the end of therapy 26 patients (45%) had a complete or partial response. Four patients (7%) had a stable response, 25 (43%) failed therapy and 4 (7%) were discontinued from voriconazole because of intolerance. Success rates were…
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“Among 4 pediatric patients who received voriconazole as salvage therapy, candidemia cleared in 2 of 2 patients and disseminated candidiasis resolved in 1 of 2 patients [47].”
From Guidelines for Treatment of Candidiasis (2004) · cites this paper as [47]
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Cites
Chronic Granulomatous Disease: Report on a National Registry of 368 Patients
Winkelstein, J. A., Marino, M. C., Johnston, R. B., Boyle, J., Curnutte, J., Gallin, J. I., Malech, H. L., Holland, S. M., Ochs, H., Quie, P., et al. (2000) · Medicine · doi:10.1097/00005792-200005000-00003 · Cited by 1,728
Current and emerging azole antifungal agents
Sheehan, D. J., Hitchcock, C. A., & Sibley, C. M. (1999) · Clinical Microbiology Reviews · doi:10.1128/cmr.12.1.40 · Cited by 1,137
Walsh, T. J., Pappas, P., Winston, D. J., Lazarus, H. M., Petersen, F., Raffalli, J., Yanovich, S., Stiff, P., Greenberg, R., Donowitz, G., et al. (2002) · New England Journal of Medicine · doi:10.1056/nejm200201243460403 · Cited by 979
Self-citationBoutati, E. I., & Anaissie, E. J. (1997) · Blood · doi:10.1182/blood.v90.3.999 · Cited by 568
Groll, A. H., Piscitelli, S. C., & Walsh, T. J. (1998) · Advances in pharmacology · doi:10.1016/s1054-3589(08)60129-5 · Cited by 377
Espinel-Ingroff, A. V. (1998) · Journal of Clinical Microbiology · doi:10.1128/jcm.36.1.198-202.1998 · Cited by 357
Alliot, C., Rigaud, P., & Derolland, P. (2003) · UroOncology · doi:10.1080/1561095021000089391 · Cited by 297
Walsh, T. J., & Groll, A. H. (1999) · Transplant Infectious Disease · doi:10.1034/j.1399-3062.1999.010404.x · Cited by 294
Self-citationAspergillosis of the central nervous system: Clinicopathological analysis of 17 patients
Walsh, T. J., Hier, D. B., & Caplan, L. R. (1985) · Annals of Neurology · doi:10.1002/ana.410180511 · Cited by 257
Self-citationNesky, M. A., McDougal, E. C., & Peacock, J. E. (2000) · Clinical Infectious Diseases · doi:10.1086/314042 · Cited by 214
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Research works printed but not linked: 5
- Walsh, 1995, Adv Pediatr Infect Dis, 11, 187
- Viviani, 1998, Med Mycol, 36, 194
- Bomelburg, 1994, Hematol Blood Transf, 36, 778
- Ritter, 1995, Baillieres Clin Infect Dis, 2, 179
- Abbasi, 1999, Clin Infect Dis, 29, 1210, 10.1086/313445 · DOI
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Ullmann, A. J., Aguado, J. M., Arikan-Akdagli, S., Denning, D. W., Groll, A. H., Lagrou, K., Lass-Flörl, C., Lewis, R. E., Munoz, P., Verweij, P. E., et al. (2018) · Clinical Microbiology and Infection · doi:10.1016/j.cmi.2018.01.002 · Cited by 1,556
Self-citationGuidelines for Treatment of Candidiasis
Pappas, P. G., Rex, J. H., Sobel, J. D., Filler, S. G., Dismukes, W. E., Walsh, T. J., & Edwards, J. E. (2004) · Clinical Infectious Diseases · doi:10.1086/380796 · Cited by 1,440
Self-citationKullberg, B., Sobel, J., Ruhnke, M., Pappas, P., Viscoli, C., Rex, J., Cleary, J., Rubinstein, E., Church, L., Brown, J., et al. (2005) · The Lancet · doi:10.1016/s0140-6736(05)67490-9 · Cited by 521
Self-citationHope, W. W., Castagnola, E., Groll, A. H., Roilides, E., Akova, M., Arendrup, M. C., Arikan-Akdagli, S., Bassetti, M., Bille, J., Cornely, O. A., et al. (2012) · Clinical Microbiology and Infection · doi:10.1111/1469-0691.12040 · Cited by 360
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Metadata
- Authors
- WALSH, T. J., LUTSAR, I., DRISCOLL, T., DUPONT, B., RODEN, M., GHAHRAMANI, P., HODGES, M., GROLL, A. H., & PERFECT, J. R.
- Affiliations
- National Institutes of Health (US)
- ORCID
- Venue
- The Pediatric Infectious Disease Journal
- Published
- 2002-03
- Volume
- 21
- Issue
- 3
- Pages
- 240-248
- ISSN
- 0891-3668 (ISSN-L)
- OpenAlex
- W1986100989
- Cited by
- 431
- References
- 36
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 1 · 2023: 2 · 2022: 7 · 2021: 2 · 2020: 10 · 2019: 6 · 2018: 5 · 2017: 8 · 2016: 11 · 2015: 8 · 2014: 15 · 2013: 15 · 2012: 23
- FWCI
- 24.50
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Pediatric Infectious Disease Journal (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Health Sciences › Medicine › Infectious Diseases › Fungal Infections and Studies
- Life Sciences › Immunology and Microbiology › Immunology › Immunodeficiency and Autoimmune Disorders
- Keywords
- voriconazole, invasive fungal infections, pediatric patients, aspergillosis, scedosporiosis, invasive candidiasis, chronic granulomatous disease, hematologic malignancies, refractory fungal infection, compassionate release, adverse drug reactions, hepatic transaminases, photosensitivity, treatment efficacy and safety, drug repurposing
- MeSH terms
- Adolescent, Antifungal Agents, Aspergillosis, Child, Child, Preschool, Drug Administration Schedule, Female, Granulomatous Disease, Chronic, Humans, Infant, Male, Mycoses, Pyrimidines, Triazoles, Treatment Failure, Hematologic Neoplasms, Voriconazole
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