The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
The Notch Ligand, Jagged-1, Influences the Development of Primitive Hematopoietic Precursor Cells
Abstract
We examined the expression of two members of theNotch family, Notch-1 and Notch-2, and one Notch ligand, Jagged-1, in hematopoietic cells. Both Notch-1 and Notch-2 were detected in murine marrow precursors (Lin−Sca-1+c-kit+). The Notch ligand, Jagged-1, was not detected in whole marrow or in precursors. However, Jagged-1 was seen in cultured primary murine fetal liver stroma, cultured primary murine bone marrow stroma, and in stromal cell lines. These results indicate a potential role for Notch-Notch ligand interactions in hematopoiesis. To further test this possibility, the effect of Jagged-1 on murine marrow precursor cells was assessed by coculturing sorted precursor cells (Lin−Sca-1+c-kit+) with a 3T3 cell layer that expressed human Jagged-1 or by incubating sorted precursors with beads coated with the purified extracellular domain of human Jagged-1 (Jagged-1ext). We found that Jagged-1, presented both on the cell surface and on beads, promoted a twofold to threefold increase in the formation of primitive precursor cell populations. These results suggest a potential use for Notch ligands in expanding precursor cell populations in vitro.
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Hirano, T., Yasukawa, K., Harada, H., Taga, T., Watanabe, Y., Matsuda, T., Kashiwamura, S.-I., Nakajima, K., Koyama, K., Iwamatsu, A., et al. (1986) · Nature · doi:10.1038/324073a0 · Cited by 2,139
Ellisen, L. W., Bird, J., West, D. C., Soreng, A. L., Reynolds, T. C., Smith, S. D., & Sklar, J. (1991) · Cell · doi:10.1016/0092-8674(91)90111-b · Cited by 1,696
Artavanis-Tsakonas, S., Matsuno, K., & Fortini, M. E. (1995) · Science · doi:10.1126/science.7716513 · Cited by 1,303
Self-citationExpression of a Delta homologue in prospective neurons in the chick
Henrique, D., Adam, J., Myat, A., Chitnis, A., Lewis, J., & Ish-Horowicz, D. (1995) · Nature · doi:10.1038/375787a0 · Cited by 992
Isolation of Monoclonal Antibodies Specific for Human c-myc Proto-Oncogene Product
Evan, G. I., Lewis, G. K., Ramsay, G., & Bishop, J. M. (1985) · Molecular and Cellular Biology · doi:10.1128/mcb.5.12.3610-3616.1985 · Cited by 794
The choice of cell fate in the epidermis of Drosophila
Heitzler, P., & Simpson, P. (1991) · Cell · doi:10.1016/0092-8674(91)90263-x · Cited by 743
Chitnis, A., Henrique, D., Lewis, J., Ish-Horowicz, D., & Kintner, C. (1995) · Nature · doi:10.1038/375761a0 · Cited by 675
Jagged: A mammalian ligand that activates notch1
Lindsell, C. E., Shawber, C. J., Boulter, J., & Weinmaster, G. (1995) · Cell · doi:10.1016/0092-8674(95)90294-5 · Cited by 604
Notch4/int-3, a mammary proto-oncogene, is an endothelial cell-specific mammalian Notch gene
Uyttendaele, H., Marazzi, G., Wu, G., Yan, Q., Sassoon, D., & Kitajewski, J. (1996) · Development · doi:10.1242/dev.122.7.2251 · Cited by 485
Notch is required for successive cell decisions in the developing Drosophila retina.
Cagan, R. L., & Ready, D. F. (1989) · Genes & Development · doi:10.1101/gad.3.8.1099 · Cited by 472
Cited by
Notch Signaling: Cell Fate Control and Signal Integration in Development
Artavanis-Tsakonas, S., Rand, M. D., & Lake, R. J. (1999) · Science · doi:10.1126/science.284.5415.770 · Cited by 5,909
Self-citationA presenilin-1-dependent γ-secretase-like protease mediates release of Notch intracellular domain
De Strooper, B., Annaert, W., Cupers, P., Saftig, P., Craessaerts, K., Mumm, J. S., Schroeter, E. H., Schrijvers, V., Wolfe, M. S., Ray, W. J., et al. (1999) · Nature · doi:10.1038/19083 · Cited by 2,100
Notch regulation of lymphocyte development and function
Radtke, F., Wilson, A., Mancini, S. J. C., & MacDonald, H. R. (2004) · Nature Immunology · doi:10.1038/ni1045 · Cited by 539
Harada, H., Kettunen, P., Jung, H.-S., Mustonen, T., Wang, Y. A., & Thesleff, I. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.147.1.105 · Cited by 517
Rb Regulates Interactions between Hematopoietic Stem Cells and Their Bone Marrow Microenvironment
Walkley, C. R., Shea, J. M., Sims, N. A., Purton, L. E., & Orkin, S. H. (2007) · Cell · doi:10.1016/j.cell.2007.03.055 · Cited by 424
Self-citation
Metadata
- Authors
- Varnum-Finney, B., Purton, L. E., Yu, M., Brashem-Stein, C., Flowers, D., Staats, S., Moore, K. A., Le Roux, I., Mann, R., Gray, G., Artavanis-Tsakonas, S., & Bernstein, I. D.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 1998-06-01
- Volume
- 91
- Issue
- 11
- Pages
- 4084-4091
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W8143991
- Cited by
- 324
- References
- 35
- FWCI
- 14.43
- Type
- journal article
- Language
- en
- Open access
- closed
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- The paper
- Varnum-Finney, B., Purton, L. E., Yu, M., Brashem-Stein, C., Flowers, D., Staats, S., Moore, K. A., Le Roux, I., Mann, R., Gray, G., Artavanis-Tsakonas, S., & Bernstein, I. D. (1998). The Notch Ligand, Jagged-1, Influences the Development of Primitive Hematopoietic Precursor Cells. Blood. https://doi.org/10.1182/blood.v91.11.4084
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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