Notch regulation of lymphocyte development and function
Open accessAbstract
Notch proteins regulate a broad spectrum of cell fate decisions and differentiation processes during fetal and postnatal development. Mammals have four Notch receptors that bind five different ligands. The function of Notch signaling during lymphopoiesis and T cell neoplasia, based on gain-of-function and conditional loss-of-function approaches for the Notch1 receptor, indicates Notch1 is essential in T cell lineage commitment. Recent studies have addressed the involvement of other Notch receptors and ligands as well as their downstream targets, demonstrating additional functions of Notch signaling in embryonic hematopoiesis, intrathymic T cell development, B cell development and peripheral T cell function.
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Notch ligands are the most important environmental signals thymus stroma provides to developing T cells across vertebrates.
“Notch ligands are the most important of all the environmental signals that the thymus stroma provides to developing T cells, apparently across all vertebrates (59–61)”
From Mechanisms of Action of Hematopoietic Transcription Factor PU.1 in Initiation of T-Cell Development (2019) · cites this paper as [59]
Cites
Regulation of Notch Signaling by O-Linked Fucose
Okajima, T., & Irvine, K. D. (2002) · Cell · doi:10.1016/s0092-8674(02)01114-5 · Cited by 386 · see citing works
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Alzheimer's Disease: From Pathology to Therapeutic Approaches
Jakob‐Roetne, R., & Jacobsen, H. (2009) · Angewandte Chemie International Edition · doi:10.1002/anie.200802808 · Cited by 626 · see citing works
Chromosomally unstable mouse tumours have genomic alterations similar to diverse human cancers
Maser, R. S., Choudhury, B., Campbell, P. J., Feng, B., Wong, K.-K., Protopopov, A., O’Neil, J., Gutierrez, A., Ivanova, E., Perna, I., et al. (2007) · Nature · doi:10.1038/nature05886 · Cited by 377 · see citing works
Canonical Notch Signaling Is Dispensable for the Maintenance of Adult Hematopoietic Stem Cells
Maillard, I., Koch, U., Dumortier, A., Shestova, O., Xu, L., Sai, H., Pross, S. E., Aster, J. C., Bhandoola, A., Radtke, F., et al. (2008) · Cell Stem Cell · doi:10.1016/j.stem.2008.02.011 · Cited by 317 · see citing works
Self-citationMechanisms of Action of Hematopoietic Transcription Factor PU.1 in Initiation of T-Cell Development
Rothenberg, E. V., Hosokawa, H., & Ungerbäck, J. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00228 · Cited by 99 · see citing works
Penninkilampi, R., Brothers, H. M., & Eslick, G. D. (2016) · Journal of Alzheimer’s Disease · doi:10.3233/jad-160275 · Cited by 42 · see citing works
Tsuchiya, S., Tachida, Y., Segi-Nishida, E., Okuno, Y., Tamba, S., Tsujimoto, G., Tanaka, S., & Sugimoto, Y. (2009) · BMC Genomics · doi:10.1186/1471-2164-10-35 · Cited by 15 · see citing works
- Authors
- Radtke, F., Wilson, A., Mancini, S. J. C., & MacDonald, H. R.
- Affiliations
- Ludwig Cancer Research (BE)
- Corresponding author
- Radtke, Freddy
- Wilson, Anne
- Venue
- Nature Immunology
- Published
- 2004-02-25
- Volume
- 5
- Issue
- 3
- Pages
- 247-253
- ISSN
- 1529-2908 (ISSN-L)
- 1529-2916
- OpenAlex
- W2017719081
- Cited by
- 539
- References
- 1
- Citations by year
- 2026: 4 · 2025: 10 · 2024: 10 · 2023: 3 · 2022: 7 · 2021: 8 · 2020: 10 · 2019: 10 · 2018: 9 · 2017: 11 · 2016: 11 · 2015: 13 · 2014: 18 · 2013: 19 · 2012: 35
- FWCI
- 4.93
- Type
- journal article
- Language
- en
- Open access
- green
- infoscience.epfl.ch
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Immunology (publishedVersion)
- PubMed (publishedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
- IRIS (submittedVersion)
- SERVAL (Université de Lausanne) (submittedVersion)
- Funders
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Keywords
- Notch signaling, Notch receptor, Notch ligands, Notch1, lymphocyte development, T cell lineage commitment, embryonic hematopoiesis, B cell development, cell fate determination
- MeSH terms
- Animals, B-Lymphocytes, Hematopoiesis, Hematopoietic Stem Cells, Humans, Membrane Proteins, T-Lymphocytes, Thymus Gland, Signal Transduction, Leukemia, T-Cell, Cell Lineage, Lymphopoiesis, Mice, Receptors, Notch
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