The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
In vivo generation of human dendritic cell subsets by Flt3 ligand
Abstract
Dendritic cells (DCs) represent a family of ontogenically distinct leukocytes involved in immune response regulation. The ability of DCs to stimulate T-cell immunity has led to their use as vectors for immunotherapy vaccines. However, it is unclear whether and to what degree in vitro–generated DCs are representative of DCs that develop in vivo. Treatment of mice with human Flt3 ligand (FL) dramatically increases the number of DCs. We report here that administration of FL to healthy human volunteers increased the number of circulating CD11c+ IL-3Rlow DC (mean 44-fold) and CD11c− IL-3Rhigh DC precursors (mean 12-fold). Moreover, the CD11c+ DCs were efficient stimulators of T cells in vitro. Thus, FL can expand the number of circulating, functionally competent human DCs in vivo.
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Wu, L., Li, C. L., & Shortman, K. (1996) · The Journal of experimental medicine · doi:10.1084/jem.184.3.903 · Cited by 400
Cited by
Merad, M., Sathe, P., Helft, J., Miller, J., & Mortha, A. (2013) · Annual Review of Immunology · doi:10.1146/annurev-immunol-020711-074950 · Cited by 2,309
D'Amico, A., & Wu, L. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20030107 · Cited by 386
Dendritic Cell–Based Cancer Vaccines
Santos, P. M., & Butterfield, L. H. (2018) · The Journal of Immunology · doi:10.4049/jimmunol.1701024 · Cited by 361
DEVELOPMENT OF HUMAN LYMPHOID CELLS
Blom, B., & Spits, H. (2006) · Annual Review of Immunology · doi:10.1146/annurev.immunol.24.021605.090612 · Cited by 339
Modulating the immune response with dendritic cells and their growth factors
Pulendran, B., Banchereau, J., Maraskovsky, E., & Maliszewski, C. (2001) · Trends in Immunology · doi:10.1016/s1471-4906(00)01794-4 · Cited by 263
Self-citation
Metadata
- Authors
- Maraskovsky, E., Daro, E., Roux, E., Teepe, M., Maliszewski, C. R., Hoek, J., Caron, D., Lebsack, M. E., & McKenna, H. J.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2000-08-01
- Volume
- 96
- Issue
- 3
- Pages
- 878-884
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W1858218633
- Cited by
- 407
- References
- 1
- FWCI
- 11.25
- Type
- journal article
- Language
- en
- Open access
- closed
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- Maraskovsky, E., Daro, E., Roux, E., Teepe, M., Maliszewski, C. R., Hoek, J., Caron, D., Lebsack, M. E., & McKenna, H. J. (2000). In vivo generation of human dendritic cell subsets by Flt3 ligand. Blood. https://doi.org/10.1182/blood.v96.3.878
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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