Cited by 274Proteoglycans and glycosaminoglycans researchMultiple Myeloma Research and TreatmentsProtease and Inhibitor Mechanisms

The DOI matches its Crossref record; 37 of the 38 references it cites were found in a registry or an index.

Cell surface proteoglycan syndecan-1 mediates hepatocyte growth factor binding and promotes Met signaling in multiple myeloma

Open access

Derksen, Patrick W. B., Keehnen, Robert M. J., Evers, Ludo M., van Oers, Marinus H. J., Spaargaren, Marcel, Pals, Steven T.·2002·Blood

DOI 10.1182/blood.v99.4.1405

Open this paper in CoChat — free account Open PDF

Abstract

Heparan sulfate proteoglycans (HSPGs) play a crucial role in growth regulation by assembling signaling complexes and presenting growth factors to their cognate receptors. Within the immune system, expression of the HSPG syndecan-1 (CD138) is characteristic of terminally differentiated B cells, ie, plasma cells, and their malignant counterpart, multiple myeloma (MM). This study explored the hypothesis that syndecan-1 might promote growth factor signaling and tumor growth in MM. For this purpose, the interaction was studied between syndecan-1 and hepatocyte growth factor (HGF), a putative paracrine and autocrine regulator of MM growth. The study demonstrates that syndecan-1 is capable of binding HGF and that this growth factor is indeed a potent stimulator of MM survival and proliferation. Importantly, the interaction of HGF with heparan sulfate moieties on syndecan-1 strongly promotes HGF-mediated signaling, resulting in enhanced activation of Met, the receptor tyrosine kinase for HGF. Moreover, HGF binding to syndecan-1 promotes activation of the phosphatidylinositol 3-kinase/protein kinase B and RAS/mitogen-activated protein kinase pathways, signaling routes that have been implicated in the regulation of cell survival and proliferation, respectively. These results identify syndecan-1 as a functional coreceptor for HGF that promotes HGF/Met signaling in MM cells, thus suggesting a novel function for syndecan-1 in MM tumorigenesis.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1182/blood.v99.4.1405

Cites

37 of 37 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery
Datta, S. R., Dudek, H., Tao, X., Masters, S., Fu, H., Gotoh, Y., & Greenberg, M. E. (1997) · Cell · doi:10.1016/s0092-8674(00)80405-5 · Cited by 5,689
Functions of Cell Surface Heparan Sulfate Proteoglycans
Bernfield, M. R., Götte, M., Park, P. W., Reizes, O., Fitzgerald, M. L., Lincecum, J. M., & Zako, M. (1999) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.68.1.729 · Cited by 2,722
Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptor
Yayon, A., Klagsbrun, M., Esko, J. D., Leder, P., & Ornitz, D. M. (1991) · Cell · doi:10.1016/0092-8674(91)90512-w · Cited by 2,440
Interleukin-3-Induced Phosphorylation of BAD Through the Protein Kinase Akt
Peso, L. D., González-Garcı́a, M., Page, C., Herrera, R., & Nuñez, G. (1997) · Science · doi:10.1126/science.278.5338.687 · Cited by 1,797
Germline and somatic mutations in the tyrosine kinase domain of the MET proto-oncogene in papillary renal carcinomas
Schmidt, L. S., Duh, F.-M. C., Chen, F., Kishida, T., Glenn, G. M., Choyke, P. L., Scherer, S. W., Zhuang, Z., Lubensky, I. A., Dean, M. C., et al. (1997) · Nature Genetics · doi:10.1038/ng0597-68 · Cited by 1,517
Requirement of Heparan Sulfate for bFGF-Mediated Fibroblast Growth and Myoblast Differentiation
Rapraeger, A. C., Krufka, A., & Olwin, B. B. (1991) · Science · doi:10.1126/science.1646484 · Cited by 1,508
A multifunctional docking site mediates signaling and transformation by the hepatocyte growth factor/scatter factor receptor family
Ponzetto, C., Bardelli, A., Zhen, Z., Maina, F., Zonca, P. D., Giordano, S., Graziani, A., Panayotou, G., & Comoglio, P. M. (1994) · Cell · doi:10.1016/0092-8674(94)90318-2 · Cited by 994
Multiple Myeloma: Increasing Evidence for a Multistep Transformation Process
Hallek, M. J., Bergsagel, P. L., & Anderson, K. C. (1998) · Blood · doi:10.1182/blood.v91.1.3 · Cited by 750
Regulated Diversity of Heparan Sulfate*
Lindahl, U., Kusche-Gullberg, M., & Kjellén, L. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.39.24979 · Cited by 688
Ets transcription factors: nuclear effectors of the Ras–MAP-kinase signaling pathway
Wasylyk, B., Hagman, J. R., & Gutierrez‐Hartmann, A. (1998) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(98)01211-0 · Cited by 506

Show all 38 references

Sorted by citations

The sweet and sour of cancer: glycans as novel therapeutic targets
Fuster, M. M., & Esko, J. D. (2005) · Nature reviews. Cancer · doi:10.1038/nrc1649 · Cited by 1,389
Roles of heparan-sulphate glycosaminoglycans in cancer
Sasisekharan, R., Shriver, Z. H., Venkataraman, G., & Narayanasami, U. (2002) · Nature reviews. Cancer · doi:10.1038/nrc842 · Cited by 621
Proteoglycans in cancer biology, tumour microenvironment and angiogenesis
Iozzo, R. V., & Sanderson, R. D. (2010) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2010.01236.x · Cited by 579
BAFF and APRIL protect myeloma cells from apoptosis induced by interleukin 6 deprivation and dexamethasone
Moreaux, J., Legouffe, E., Jourdan, E., Quittet, P., Rème, T., Lugagne, C., Moine, P., Rossi, J.-F., Klein, B., & Tarte, K. (2004) · Blood · doi:10.1182/blood-2003-06-1984 · Cited by 558
The extracellular matrix as a multitasking player in disease
Theocharis, A. D., Manou, D., & Karamanos, N. K. (2019) · FEBS Journal · doi:10.1111/febs.14818 · Cited by 533
Molecular functions of syndecan-1 in disease
Teng, Y. H.-F., Aquino, R. S., & Park, P. W. (2011) · Matrix Biology · doi:10.1016/j.matbio.2011.10.001 · Cited by 383
Syndecans in inflammation
Götte, M. (2003) · The FASEB Journal · doi:10.1096/fj.02-0739rev · Cited by 358
Illegitimate WNT signaling promotes proliferation of multiple myeloma cells
Derksen, P. W. B., Tjin, E. P. M., Meijer, H. P., Klok, M. D., MacGillavry, H. D., van Oers, M. H. J., Lokhorst, H. M., Bloem, A. C., Clevers, H. C., Nusse, R., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0305855101 · Cited by 309
Self-citation
Syndecans – key regulators of cell signaling and biological functions
Afratis, N. A., Nikitovic, D., Multhaupt, H. A. B., Theocharis, A. D., Couchman, J., & Karamanos, N. K. (2016) · FEBS Journal · doi:10.1111/febs.13940 · Cited by 292
The level of TACI gene expression in myeloma cells is associated with a signature of microenvironment dependence versus a plasmablastic signature
Moreaux, J., Cremer, F. W., Reme, T. X., Raab, M. S., Mahtouk, K., Kaukel, P., Pantesco, V., Vos, J. D., Jourdan, É., Jauch, A. S., et al. (2005) · Blood · doi:10.1182/blood-2004-11-4512 · Cited by 259
SST0001, a Chemically Modified Heparin, Inhibits Myeloma Growth and Angiogenesis via Disruption of the Heparanase/Syndecan-1 Axis
Ritchie, J. P., Ramani, V. C., Ren, Y., Naggi, A., Torri, G., Casu, B., Penco, S., Pisano, C., Carminati, P., Tortoreto, M., et al. (2011) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-10-2476 · Cited by 252
Heparan sulfate proteoglycans: structure, protein interactions and cell signaling
Dreyfuss, J. L., Regatieri, C. V., Jarrouge, T. R., Cavalheiro, R. P., Sampaio, L. O., & Nader, H. B. (2009) · Anais da Academia Brasileira de Ciências · doi:10.1590/s0001-37652009000300007 · Cited by 264
Role of B-Cell–Activating Factor in Adhesion and Growth of Human Multiple Myeloma Cells in the Bone Marrow Microenvironment
Tai, Y., Li, X., Breitkreutz, I., Song, W., Neri, P. E., Catley, L. P., Podar, K., Hideshima, T., Chauhan, D., Raje, N. S., et al. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-0190 · Cited by 237
Defects in keratinocyte activation during wound healing in the syndecan-1-deficient mouse
Stepp, M. A., Gibson, H. E., Gala, P. H., Iglesia, D. D. S., Pajoohesh‐Ganji, A., Pal‐Ghosh, S., Brown, M., Aquino, C. J., Schwartz, A. M., Goldberger, O., et al. (2002) · Journal of Cell Science · doi:10.1242/jcs.00128 · Cited by 230
Heparan sulfate proteoglycan binding promotes APRIL-induced tumor cell proliferation
Hendriks, J., Planelles, L., Odding, J. H., Hardenberg, G., Pals, S. T., Hahne, M., Spaargaren, M., & Medema, J. P. (2005) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401647 · Cited by 216
Self-citation
Survival and Proliferation Factors of Normal and Malignant Plasma Cells
Klein, B., Tarte, K., Jourdan, M., Mathouk, K., Moreaux, J., Jourdan, É., Legouffe, É., Vos, J. D., & Rossic, J. F. (2003) · International Journal of Hematology · doi:10.1007/bf02983377 · Cited by 217
Gene expression profiling of plasma cells and plasmablasts: toward a better understanding of the late stages of B-cell differentiation
Tarte, K., Zhan, F., Vos, J. D., Klein, B., & Shaughnessy, J. D. (2003) · Blood · doi:10.1182/blood-2002-10-3161 · Cited by 215
Proteoglycans remodeling in cancer: Underlying molecular mechanisms
Theocharis, A. D., & Karamanos, N. K. (2017) · Matrix Biology · doi:10.1016/j.matbio.2017.10.008 · Cited by 205
The Monoclonal Antibody nBT062 Conjugated to Cytotoxic Maytansinoids Has Selective Cytotoxicity Against CD138-Positive Multiple Myeloma Cells In vitro and In vivo
Ikeda, H., Hideshima, T., Fulciniti, M., Lutz, R. J., Yasui, H., Okawa, Y., Kiziltepe, T., Vallet, S., Pozzi, S., Santo, L., et al. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-08-2867 · Cited by 203
The Role of Heparanase and Sulfatases in the Modification of Heparan Sulfate Proteoglycans within the Tumor Microenvironment and Opportunities for Novel Cancer Therapeutics
Hammond, E., Khurana, A., Shridhar, V., & Dredge, K. S. (2014) · Frontiers in Oncology · doi:10.3389/fonc.2014.00195 · Cited by 192
Heparan sulfate proteoglycans and heparanase—partners in osteolytic tumor growth and metastasis
Sanderson, R. D., Yang, Y., Suva, L. J., & Kelly, T. J. (2004) · Matrix Biology · doi:10.1016/j.matbio.2004.08.004 · Cited by 190
The heparanase/syndecan‐1 axis in cancer: mechanisms and therapies
Ramani, V. C., Purushothaman, A., Stewart, M. D., Thompson, C. A., Vlodavsky, I., Au, J. L., & Sanderson, R. D. (2013) · The FEBS Journal · doi:10.1111/febs.12168 · Cited by 189
Aberrant Wnt signaling in multiple myeloma: molecular mechanisms and targeting options
van Andel, H., Kocemba, K. A., Spaargaren, M., & Pals, S. T. (2019) · Leukemia · doi:10.1038/s41375-019-0404-1 · Cited by 188
Self-citation
Heparanase Stimulation of Protease Expression Implicates It as a Master Regulator of the Aggressive Tumor Phenotype in Myeloma
Purushothaman, A., Chen, L., Yang, Y., & Sanderson, R. D. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m806266200 · Cited by 180
Syndecans as cell surface receptors: Unique structure equates with functional diversity
Choi, Y., Chung, H., Jung, H., Couchman, J., & Oh, E. (2010) · Matrix Biology · doi:10.1016/j.matbio.2010.10.006 · Cited by 175
Importance of the bone marrow microenvironment in inducing the angiogenic response in multiple myeloma
Ribatti, D., Nico, B., & Vacca, A. (2006) · Oncogene · doi:10.1038/sj.onc.1209456 · Cited by 175
Roles of Proteoglycans and Glycosaminoglycans in Cancer Development and Progression
Wei, J., Hu, M., Huang, K., Lin, S., & Du, H. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21175983 · Cited by 169
HGF inhibits BMP-induced osteoblastogenesis: possible implications for the bone disease of multiple myeloma
Standal, T., Abildgaard, N., Fagerli, U.-M., Stordal, B., Hjertner, Ø., Borset, M., & Sundan, A. (2007) · Blood · doi:10.1182/blood-2006-07-034884 · Cited by 167
CpG DNA activation and plasma-cell differentiation of CD27− naive human B cells
Huggins, J., Pellegrin, T., Felgar, R. E., Wei, C., Brown, M., Zheng, B., MILNER, E. C. B., Bernstein, S. H., Sanz, I., & Zand, M. S. (2006) · Blood · doi:10.1182/blood-2006-03-008441 · Cited by 157
The hepatocyte growth factor/Met pathway controls proliferation and apoptosis in multiple myeloma
Derksen, P. W. B., de Gorter, D. J. J., Meijer, H. P., Bende, R. J., van Dijk, M., Lokhorst, H. M., Bloem, A. C., Spaargaren, M., & Pals, S. T. (2003) · Leukemia · doi:10.1038/sj.leu.2402875 · Cited by 156
Self-citation
Autism-like socio-communicative deficits and stereotypies in mice lacking heparan sulfate
Irie, F., Badie-Mahdavi, H., & Yamaguchi, Y. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1117881109 · Cited by 153
Heparin: a potent inhibitor of hepcidin expression in vitro and in vivo
Poli, M., Girelli, D., Campostrini, N., Maccarinelli, F., Finazzi, D., Luscieti, S., Nai, A., & Arosio, P. (2011) · Blood · doi:10.1182/blood-2010-06-289082 · Cited by 148
Mechano‐biology of skeletal muscle hypertrophy and regeneration: Possible mechanism of stretch‐induced activation of resident myogenic stem cells
Tatsumi, R. (2009) · Animal Science Journal · doi:10.1111/j.1740-0929.2009.00712.x · Cited by 143
Induction of Syndecan-1 Expression in Stromal Fibroblasts Promotes Proliferation of Human Breast Cancer Cells
Maeda, T., Alexander, C. M., & Friedl, A. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-2439 · Cited by 141
HSulf-1 and HSulf-2 Are Potent Inhibitors of Myeloma Tumor Growth in Vivo
Dai, Y., Yang, Y., MacLeod, V., Yue, X., Rapraeger, A. C., Shriver, Z. H., Venkataraman, G., Sasisekharan, R., & Sanderson, R. D. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m508136200 · Cited by 147
Heparanase influences expression and shedding of syndecan-1, and its expression by the bone marrow environment is a bad prognostic factor in multiple myeloma
Mahtouk, K., Hose, D., Raynaud, P., Hundemer, M., Jourdan, M., Jourdan, É., Pantesco, V., Baudard, M., Vos, J. D., Larroque, M., et al. (2007) · Blood · doi:10.1182/blood-2006-08-043232 · Cited by 137
Syndecan-1 expression by stromal fibroblasts promotes breast carcinoma growth in vivo and stimulates tumor angiogenesis
Maeda, T., Desouky, J., & Friedl, A. (2005) · Oncogene · doi:10.1038/sj.onc.1209168 · Cited by 135
Heparanase promotes the spontaneous metastasis of myeloma cells to bone
Yang, Y., MacLeod, V., Bendre, M. S., Huang, Y., Theus, A. M., Miao, H., Kussie, P. H., Yaccoby, S., Epstein, J., Suva, L. J., et al. (2004) · Blood · doi:10.1182/blood-2004-06-2141 · Cited by 134
The syndecan-1 heparan sulfate proteoglycan is a viable target for myeloma therapy
Yang, Y., MacLeod, V., Dai, Y., Khotskaya-Sample, Y., Shriver, Z. H., Venkataraman, G., Sasisekharan, R., Naggi, A., Torri, G., Casu, B., et al. (2007) · Blood · doi:10.1182/blood-2007-04-082495 · Cited by 133
Cell-surface heparan sulfate proteoglycans as multifunctional integrators of signaling in cancer
Hassan, N., Greve, B., Espinoza‐Sánchez, N. A., & Götte, M. (2020) · Cellular Signalling · doi:10.1016/j.cellsig.2020.109822 · Cited by 129
Syndecan-1: a dynamic regulator of the myeloma microenvironment
Sanderson, R. D., & Yang, Y. (2007) · Clinical & Experimental Metastasis · doi:10.1007/s10585-007-9125-3 · Cited by 128
APRIL and TACI interact with syndecan‐1 on the surface of multiple myeloma cells to form an essential survival loop
Moreaux, J., Sprynski, A. C., Dillon, S. R., Mahtouk, K., Jourdan, M., Ythier, A., Moine, P., Robert, N., Jourdan, É., Rossi, J. F., et al. (2009) · European Journal Of Haematology · doi:10.1111/j.1600-0609.2009.01262.x · Cited by 119
Heparanase Plays a Dual Role in Driving Hepatocyte Growth Factor (HGF) Signaling by Enhancing HGF Expression and Activity
Ramani, V. C., Yang, Y., Ren, Y., Li, N., & Sanderson, R. D. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.183277 · Cited by 115
Angiogenesis and Multiple Myeloma
Giuliani, N., Storti, P., Bolzoni, M., Palma, B. D., & Bonomini, S. (2011) · Cancer Microenvironment · doi:10.1007/s12307-011-0072-9 · Cited by 111
An expression signature of syndecan-1 (CD138), E-cadherin and c-met is associated with factors of angiogenesis and lymphangiogenesis in ductal breast carcinoma in situ
Götte, M., Kersting, C., Radke, I., Kiesel, L., & Wülfing, P. (2007) · Breast Cancer Research · doi:10.1186/bcr1641 · Cited by 110
Extravasation and homing mechanisms in multiple myeloma
Broek, I. V., Vanderkerken, K., Camp, B. V., & Riet, I. V. (2007) · Clinical & Experimental Metastasis · doi:10.1007/s10585-007-9108-4 · Cited by 109
Heparan sulphate proteoglycans are essential for the myeloma cell growth activity of EGF-family ligands in multiple myeloma
Mahtouk, K., Cremer, F. W., Rème, T., Jourdan, M., Baudard, M., Moreaux, J., Requirand, G., Fiol, G., De Vos, J., Moos, M., et al. (2006) · Oncogene · doi:10.1038/sj.onc.1209699 · Cited by 105
Syndecan-1 Is Required for Robust Growth, Vascularization, and Metastasis of Myeloma Tumors in Vivo
Khotskaya, Y. B., Dai, Y., Ritchie, J. P., MacLeod, V., Yang, Y., Zinn, K. R., & Sanderson, R. D. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.018473 · Cited by 102
Matrix metalloproteinase-2 mediates stretch-induced activation of skeletal muscle satellite cells in a nitric oxide-dependent manner
Yamada, M., Sankoda, Y., Tatsumi, R., Mizunoya, W., Ikeuchi, Y., Sunagawa, K., & Allen, R. E. (2008) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2008.02.017 · Cited by 107
Heparan sulfate proteoglycan – A common receptor for diverse cytokines
Xie, M., & Li, J. (2018) · Cellular Signalling · doi:10.1016/j.cellsig.2018.11.022 · Cited by 96
Serglycin Constitutively Secreted by Myeloma Plasma Cells Is a Potent Inhibitor of Bone Mineralization in Vitro
Theocharis, A. D., Seidel, C., Børset, M., Dobra, K., Baykov, V., Labropoulou, V., Kanakis, I., Dalas, E., Karamanos, N. K., Sundan, A., et al. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m601061200 · Cited by 99
Advances in the molecular functions of syndecan-1 (SDC1/CD138) in the pathogenesis of malignancies
Gharbaran, R. (2014) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2014.12.003 · Cited by 98
A Selective c-Met Inhibitor Blocks an Autocrine Hepatocyte Growth Factor Growth Loop in ANBL-6 Cells and Prevents Migration and Adhesion of Myeloma Cells
Hov, H., Holt, R. U., Rø, T. B., Fagerli, U., Hjorth‐Hansen, H., Baykov, V., Christensen, J. G., Waage, A., Sundan, A., & Børset, M. (2004) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-04-0874 · Cited by 96
Molecular and clinical profiles of syndecan-1 in solid and hematological cancer for prognosis and precision medicine
Akl, M. R., Nagpal, P., Ayoub, N. M., Prabhu, S. A., Gliksman, M., Tai, B., Hatipoglu, A., Goy, A. H., & Suh, K. S. (2015) · Oncotarget · doi:10.18632/oncotarget.4981 · Cited by 88
Syndecan‐1 and angiogenic cytokines in multiple myeloma: correlation with bone marrow angiogenesis and survival
Andersen, N. F., Standal, T., Nielsen, J. L., Heickendorff, L., Børset, M., Sørensen, F. B., & Abildgaard, N. (2004) · British Journal of Haematology · doi:10.1111/j.1365-2141.2004.05299.x · Cited by 91
Functional analysis of HGF/MET signaling and aberrant HGF-activator expression in diffuse large B-cell lymphoma
Tjin, E. P. M., Groen, R. W. J., Vogelzang, I., Derksen, P. W. B., Klok, M. D., Meijer, H. P., van Eeden, S., Pals, S. T., & Spaargaren, M. (2005) · Blood · doi:10.1182/blood-2005-05-1929 · Cited by 95
Self-citation
Syndecan-1 Is Involved in Osteoprotegerin-Induced Chemotaxis in Human Peripheral Blood Monocytes
Mosheimer, B. A., Kaneider, N. C., Feistritzer, C., Djanani, A. M., Sturn, D. H., Patsch, J. R., & Wiedermann, C. J. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-1895 · Cited by 91
Apoptosis and complement-mediated lysis of myeloma cells by polyclonal rabbit antithymocyte globulin
Zand, M. S., Vo, T., Pellegrin, T., Felgar, R. E., Liesveld, J. L., Ifthikharuddin, J. J., Abboud, C. N., Sanz, I., & Huggins, J. (2005) · Blood · doi:10.1182/blood-2005-06-2269 · Cited by 88
Syndecan-1 promotes Wnt/β-catenin signaling in multiple myeloma by presenting Wnts and R-spondins
Ren, Z., van Andel, H., de Lau, W., Hartholt, R. B., Maurice, M. M., Clevers, H. C., Kersten, M. J., Spaargaren, M., & Pals, S. T. (2017) · Blood · doi:10.1182/blood-2017-07-797050 · Cited by 90
Self-citation
Cancer Cell Glycocalyx and Its Significance in Cancer Progression
Kang, H., Wu, Q., Sun, A., Liu, X., Fan, Y., & Deng, X. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19092484 · Cited by 89
Matrix metalloproteinases are involved in mechanical stretch–induced activation of skeletal muscle satellite cells
Yamada, M., Tatsumi, R., Kikuiri, T., Okamoto, S., Nonoshita, S., Mizunoya, W., Ikeuchi, Y., Shimokawa, H., Sunagawa, K., & Allen, R. E. (2006) · Muscle & Nerve · doi:10.1002/mus.20601 · Cited by 87
Syndecan-1/CD147 association is essential for cyclophilin B-induced activation of p44/42 mitogen-activated protein kinases and promotion of cell adhesion and chemotaxis
Pakula, R., Melchior, A., Denys, A., Vanpouille, C., Mazurier, J., & Allain, F. (2007) · Glycobiology · doi:10.1093/glycob/cwm009 · Cited by 86
The heparan sulfate proteoglycan agrin modulates neurite outgrowth mediated by FGF-2.
Kim, M. J., Cotman, S., Halfter, W., & Cole, G. (2003) · Journal of Neurobiology · doi:10.1002/neu.10213 · Cited by 80
Caveolin-1 (P132L), a Common Breast Cancer Mutation, Confers Mammary Cell Invasiveness and Defines a Novel Stem Cell/Metastasis-Associated Gene Signature
Bonuccelli, G., Casimiro, M. C., Sotgia, F., Wang, C., Liu, M., Katiyar, S., Zhou, J., Dew, E., Capozza, F., Daumer, K. M., et al. (2009) · American Journal Of Pathology · doi:10.2353/ajpath.2009.080648 · Cited by 86
Prostate Cancer and the Met Hepatocyte Growth Factor Receptor
Knudsen, B. S., & Edlund, M. (2004) · Advances in cancer research · doi:10.1016/s0065-230x(04)91002-0 · Cited by 82
Syndecan-1 facilitates breast cancer metastasis to the brain
Sayyad, M. R., Puchalapalli, M., Vergara, N. G., Wangensteen, S. M., Moore, M., Mu, L., Edwards, C., Anderson, A., Kall, S. L., Sullivan, M. E., et al. (2019) · Breast Cancer Research and Treatment · doi:10.1007/s10549-019-05347-0 · Cited by 81
Specific structural features of syndecans and heparan sulfate chains are needed for cell signaling
Lopes, C. C., Dietrich, C. P., & Nader, H. B. (2006) · Brazilian Journal of Medical and Biological Research · doi:10.1590/s0100-879x2006000200001 · Cited by 78
The Role of Syndecan-1 in Cellular Signaling and its Effects on Heparan Sulfate Biosynthesis in Mesenchymal Tumors
Szatmári, T., & Dobra, K. (2013) · Frontiers in Oncology · doi:10.3389/fonc.2013.00310 · Cited by 90
Targeting EXT1 reveals a crucial role for heparan sulfate in the growth of multiple myeloma
Reijmers, R. M., Groen, R. W. J., Rozemuller, H., Kuil, A., de Haan-Kramer, A., Csikós, T., Martens, A. C., Spaargaren, M., & Pals, S. T. (2009) · Blood · doi:10.1182/blood-2009-02-204396 · Cited by 81
Self-citation
Heparanase-enhanced Shedding of Syndecan-1 and Its Role in Driving Disease Pathogenesis and Progression
Rangarajan, S., Richter, J. R., Richter, R. P., Bandari, S., Tripathi, K. K., Vlodavsky, I., & Sanderson, R. D. (2020) · Journal of Histochemistry & Cytochemistry · doi:10.1369/0022155420937087 · Cited by 83
Proteoglycans—Biomarkers and Targets in Cancer Therapy
Nikitovic, D., Berdiaki, A., Spyridaki, I., Krasanakis, T., Tsatsakis, A. M., & Tzanakakis, G. N. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00069 · Cited by 78
Met-Independent Hepatocyte Growth Factor-mediated regulation of cell adhesion in human prostate cancer cells
Tate, A. W., Isotani, S., Bradley, M. J., Sikes, R. A., Davis, R., Chung, L. W. K., & Edlund, M. (2006) · BMC Cancer · doi:10.1186/1471-2407-6-197 · Cited by 75
A Novel Function of Syndecan-2, Suppression of Matrix Metalloproteinase-2 Activation, Which Causes Suppression of Metastasis
Munesue, S., Yoshitomi, Y., Kusano, Y., Koyama, Y., Nishiyama, A., Nakanishi, H., Miyazaki, K., Ishimaru, T., Miyaura, S., Okayama, M., et al. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m609812200 · Cited by 74
Human Monoclonal Antibody Targeting the Heparan Sulfate Chains of Glypican-3 Inhibits HGF-Mediated Migration and Motility of Hepatocellular Carcinoma Cells
Gao, W., Kim, H., & Ho, M. (2015) · PLoS ONE · doi:10.1371/journal.pone.0137664 · Cited by 74
Syndecan-1 in B lymphoid malignancies
Sanderson, R. D., & Børset, M. (2002) · Annals of Hematology · doi:10.1007/s00277-002-0437-8 · Cited by 74
Expression of genes encoding for proteins involved in heparan sulphate and chondroitin sulphate chain synthesis and modification in normal and malignant plasma cells
Bret, C., Hose, D., Reme, T. X., Sprynski, A. C., Mahtouk, K., Schved, J., Quittet, P., Rossi, J., Goldschmidt, H., & Klein, B. (2009) · British Journal of Haematology · doi:10.1111/j.1365-2141.2009.07633.x · Cited by 76
Heparan sulfate in angiogenesis: a target for therapy
van Wijk, X. M. R., & Kuppevelt, T. H. V. (2013) · Angiogenesis · doi:10.1007/s10456-013-9401-6 · Cited by 73
Dual mode regulation of migration by lysophosphatidic acid in human gastric cancer cells
Shida, D., Kitayama, J., Yamaguchi, H., Hama, K., Aoki, J., Arai, H., Yamashita, H., Mori, K., Sako, A., Konishi, T., et al. (2004) · Experimental Cell Research · doi:10.1016/j.yexcr.2004.08.008 · Cited by 71
Glycol-split nonanticoagulant heparins are inhibitors of hepcidin expression in vitro and in vivo
Poli, M., Asperti, M., Naggi, A., Campostrini, N., Girelli, D., Corbella, M., Benzi, M., Besson‐Fournier, C., Coppin, H., Maccarinelli, F., et al. (2014) · Blood · doi:10.1182/blood-2013-07-515221 · Cited by 70
RNA‐directed agent, cordycepin, induces cell death in multiple myeloma cells
Chen, L. S., Stellrecht, C. M., & Gandhi, V. V. (2008) · British Journal of Haematology · doi:10.1111/j.1365-2141.2007.06955.x · Cited by 68
c-Cbl Is Involved in Met Signaling in B Cells and Mediates Hepatocyte Growth Factor-Induced Receptor Ubiquitination
Taher, T. E. I., Tjin, E. P. M., Beuling, E. A., Borst, J. G., Spaargaren, M., & Pals, S. T. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.7.3793 · Cited by 68
Self-citation
Heparanase, cell signaling, and viral infections
Koganti, R., Suryawanshi, R., & Shukla, D. (2020) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-020-03559-y · Cited by 67
Calcium influx through a possible coupling of cation channels impacts skeletal muscle satellite cell activation in response to mechanical stretch
Hara, M., Tabata, K., Suzuki, T., Do, M. Q., Mizunoya, W., Nakamura, M., Nishimura, S., Tabata, S., Ikeuchi, Y., Sunagawa, K., et al. (2012) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00068.2012 · Cited by 67
CAR T-cell immunotherapy of MET-expressing malignant mesothelioma
Thayaparan, T., Petrovic, R. M., Achkova, D., Zabinski, T., Davies, D. M., Klampatsa, A., Parente‐Pereira, A. C., Whilding, L. M., van der Stegen, S. J. C., Woodman, N. L., et al. (2017) · OncoImmunology · doi:10.1080/2162402x.2017.1363137 · Cited by 68
Heparan Sulfate Proteoglycans Regulate Responses to Oocyte Paracrine Signals in Ovarian Follicle Morphogenesis
Watson, L. N., Mottershead, D. G., Dunning, K. R., Robker, R. L., Gilchrist, R. B., & Russell, D. L. (2012) · Endocrinology · doi:10.1210/en.2012-1181 · Cited by 64
The Niche Factor Syndecan-1 Regulates the Maintenance and Proliferation of Neural Progenitor Cells during Mammalian Cortical Development
Wang, Q., Yang, L., Alexander, C. M., & Temple, S. (2012) · PLoS ONE · doi:10.1371/journal.pone.0042883 · Cited by 66
Extracellular Matrix Influencing HGF/c-MET Signaling Pathway: Impact on Cancer Progression
Guerra, H. N., & Freitas, V. M. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19113300 · Cited by 64
Multiple myeloma cells catalyze hepatocyte growth factor (HGF) activation by secreting the serine protease HGF-activator
Tjin, E. P. M., Derksen, P. W. B., Kataoka, H., Spaargaren, M., & Pals, S. T. (2004) · Blood · doi:10.1182/blood-2003-12-4386 · Cited by 63
Self-citation
Coreceptor functions of cell surface heparan sulfate proteoglycans
Hayashida, K., Aquino, R. S., & Park, P. W. (2022) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00050.2022 · Cited by 63
Growth factors in multiple myeloma: a comprehensive analysis of their expression in tumor cells and bone marrow environment using Affymetrix microarrays
Mahtouk, K., Moreaux, J., Hose, D., Reme, T. X., Meißner, T., Jourdan, M., Rossi, J. F., Pals, S. T., Goldschmidt, H., & Klein, B. (2010) · BMC Cancer · doi:10.1186/1471-2407-10-198 · Cited by 64
Self-citation
NK4, an antagonist of hepatocyte growth factor (HGF), inhibits growth of multiple myeloma cells: molecular targeting of angiogenic growth factor
Du, W., Hattori, Y., Yamada, T., Matsumoto, K., Nakamura, T., Sagawa, M., Otsuki, T., Niikura, T., Nukiwa, T., & Ikeda, Y. (2006) · Blood · doi:10.1182/blood-2006-02-003103 · Cited by 61
Bone marrow microenvironment in myelomagenesis: its potential role in early diagnosis
Balakumaran, A., Robey, P. G., Fedarko, N. S., & Landgren, O. (2010) · Expert Review of Molecular Diagnostics · doi:10.1586/erm.10.31 · Cited by 61
Syndecans play dual roles as cell adhesion receptors and docking receptors
Kwon, M.-J., Jang, B., Yi, J. Y., Han, I., & Oh, E. S. (2012) · FEBS Letters · doi:10.1016/j.febslet.2012.05.037 · Cited by 60
Disruption of heparan sulfate proteoglycan conformation perturbs B-cell maturation and APRIL-mediated plasma cell survival
Reijmers, R. M., Groen, R. W. J., Kuil, A., Weijer, K. C., Kimberley, F. C., Medema, J. P., Kuppevelt, T. H. V., Li, J., Spaargaren, M., & Pals, S. T. (2011) · Blood · doi:10.1182/blood-2010-12-325522 · Cited by 63
Self-citation
APRIL promotes cell-cycle progression in primary multiple myeloma cells: influence of D-type cyclin group and translocation status
Quinn, J., Glassford, J., Percy, L. A., Munson, P., Marafioti, T., Rodriguez‐Justo, M., & Yong, K. (2010) · Blood · doi:10.1182/blood-2010-01-264424 · Cited by 59
Targeting syndecan-1: new opportunities in cancer therapy
Yang, Z., Chen, S., Ying, H., & Yao, W. (2022) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00024.2022 · Cited by 62
c-Met and Its Ligand Hepatocyte Growth Factor/Scatter Factor Regulate Mature B Cell Survival in a Pathway Induced by CD74
Gordin, M., Tesio, M., Cohen, S., Gore, Y., Lantner, F., Leng, L., Bucala, R., & Shachar, I. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0902566 · Cited by 57
Glycosaminoglycans and their synthetic mimetics inhibit RANTES-induced migration and invasion of human hepatoma cells
Sutton, A., Friand, V., Papy-García, D., Dagouassat, M., Martin, L., Vassy, R., Haddad, O., Sainte‐Catherine, O., Kraemer, M., Saffar, L., et al. (2007) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-07-0114 · Cited by 57
The role of the tumor microenvironment in hematological malignancies and implication for therapy
Zhou, J. (2005) · Frontiers in bioscience · doi:10.2741/1642 · Cited by 56
Syndecans in cancer: A review of function, expression, prognostic value, and therapeutic significance
Czarnowski, D. (2021) · Cancer Treatment and Research Communications · doi:10.1016/j.ctarc.2021.100312 · Cited by 55

Authors: Derksen, P. W. B., Keehnen, R. M. J., Evers, L. M., van Oers, M. H. J., Spaargaren, M., & Pals, S. T.
Affiliations: Amsterdam UMC Location University of Amsterdam (NL)
ORCID: Derksen, Patrick W. B.
Spaargaren, Marcel
Pals, Steven T.
Venue: Blood
Publisher: American Society of Hematology
Published: 2002-02-15
Volume: 99
Issue: 4
Pages: 1405-1410
ISSN: 0006-4971 (ISSN-L)
1528-0020
DOI: 10.1182/blood.v99.4.1405
OpenAlex: W2009169267
Cited by: 274
References: 38
Citations by year: 2026: 2 · 2025: 1 · 2024: 7 · 2023: 12 · 2022: 7 · 2021: 10 · 2020: 15 · 2019: 9 · 2018: 10 · 2017: 7 · 2016: 9 · 2015: 10 · 2014: 12 · 2013: 14 · 2012: 14
FWCI: 5.56
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Blood (publishedVersion)
PubMed (publishedVersion)
Pure Amsterdam UMC (publishedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion)
Funders: KWF Kankerbestrijding
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Proteoglycans and glycosaminoglycans research
Health Sciences › Medicine › Hematology › Multiple Myeloma Research and Treatments
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Protease and Inhibitor Mechanisms
Keywords: syndecan-1, hepatocyte growth factor, MET receptor tyrosine kinase, multiple myeloma, heparan sulfate proteoglycans, co-receptors, PI3K/Akt signaling, Ras/MEK/ERK signaling, cell proliferation and survival, tumor growth
MeSH terms: Cell Division, Enzyme Activation, Humans, Membrane Glycoproteins, Multiple Myeloma, Protein Binding, Proteoglycans, Proto-Oncogene Proteins, Transfection, Tumor Cells, Cultured, Signal Transduction, Hepatocyte Growth Factor, Protein Serine-Threonine Kinases, ras Proteins, Proto-Oncogene Proteins c-met, Phosphatidylinositol 3-Kinases, MAP Kinase Signaling System, Proto-Oncogene Proteins c-akt, Syndecans, Syndecan-1

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Cell surface proteoglycan syndecan-1 mediates hepatocyte growth factor binding and promotes Met signaling in multiple myeloma

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks