Heparanase, cell signaling, and viral infections

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

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SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

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Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

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<i>PTEN</i> , a Putative Protein Tyrosine Phosphatase Gene Mutated in Human Brain, Breast, and Prostate Cancer

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Macrophage biology in development, homeostasis and disease

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STATs in cancer inflammation and immunity: a leading role for STAT3

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Cellular survival: a play in three Akts

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AKT/PKB Signaling: Navigating the Network

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Mechanism of activation of protein kinase B by insulin and IGF‐1.

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Cellular functions regulated by Src family kinases.

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TLR signaling pathways

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Drug delivery with carbon nanotubes for in vivo cancer treatment

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EGF–ERBB signalling: towards the systems level

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Phosphatidylinositol-3-OH kinase direct target of Ras

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The activation of Akt/PKB signaling pathway and cell survival

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Signal Transduction by Vascular Endothelial Growth Factor Receptors

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The Ras superfamily at a glance

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Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactions

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Clinical Methods: The History, Physical, and Laboratory Examinations

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A comprehensive pathway map of epidermal growth factor receptor signaling

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PI3K-PKB/Akt PathwayPreprint

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AKT/PKB and Other D3 Phosphoinositide-Regulated Kinases: Kinase Activation by Phosphoinositide-Dependent Phosphorylation

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Src family kinases, key regulators of signal transduction

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Targeting the EGFR signaling pathway in cancer therapy

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Signal Transduction by Vascular Endothelial Growth Factor ReceptorsPreprint

Koch, S., & Claesson‐Welsh, L. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a006502 · Cited by 913 · see citing works

EGFR-TKI resistance due to BIM polymorphism can be circumvented in combination with HDAC inhibition

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Akt-dependent regulation of NF-κB is controlled by mTOR and Raptor in association with IKKPreprint

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Activation of Matrix Metalloproteinase-9 (MMP-9) via a Converging Plasmin/Stromelysin-1 Cascade Enhances Tumor Cell Invasion

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Proteoglycans in cancer biology, tumour microenvironment and angiogenesis

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Regulation, function and clinical significance of heparanase in cancer metastasis and angiogenesis.

Ilan, N., Elkin, M., & Vlodavsky, I. (2006) · International Journal of Biochemistry and Cell Biology · doi:10.1016/j.biocel.2006.06.004 · Cited by 523 · see citing works

Heparanase: a key enzyme involved in cell invasion

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Inhibition of SARS Pseudovirus Cell Entry by Lactoferrin Binding to Heparan Sulfate Proteoglycans

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Akt/Protein Kinase B Signaling Inhibitor-2, a Selective Small Molecule Inhibitor of Akt Signaling with Antitumor Activity in Cancer Cells Overexpressing Akt

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Viruses associated with human cancer

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The macrophage response towards LPS and its control through the p38MAPK–STAT3 axis

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Heparan Sulfate Proteoglycans and Viral Attachment: True Receptors or Adaptation Bias?

Cagno, V., Tseligka, E. D., Jones, S. T., & Tapparel, C. (2019) · Viruses · doi:10.3390/v11070596 · Cited by 385 · see citing works

Regulation of Phosphorylation of Thr-308 of Akt, Cell Proliferation, and Survival by the B55α Regulatory Subunit Targeting of the Protein Phosphatase 2A Holoenzyme to Akt

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Focal Adhesion Kinase Is Upstream of Phosphatidylinositol 3-Kinase/Akt in Regulating Fibroblast Survival in Response to Contraction of Type I Collagen Matrices via a β1 Integrin Viability Signaling Pathway

Hong, X., Nho, R. S., Kahm, J., Kleidon, J., & Henke, C. A. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m313265200 · Cited by 366 · see citing works

STAT3 as a central mediator of neoplastic cellular transformation

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Activated T lymphocytes produce a matrix-degrading heparan sulphate endoglycosidase

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The Epidermal Growth Factor Receptor (EGFR) Promotes Uptake of Influenza A Viruses (IAV) into Host Cells

Eierhoff, T., Hrincius, E. R., Rescher, U., Ludwig, S., & Ehrhardt, C. (2010) · PLoS Pathogens · doi:10.1371/journal.ppat.1001099 · Cited by 340 · see citing works

Heparanase as mediator of angiogenesis: mode of action

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The involvement of lipid rafts in the regulation of integrin function

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Homologs of vascular endothelial growth factor are encoded by the poxvirus orf virus

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Human Coronavirus NL63 Utilizes Heparan Sulfate Proteoglycans for Attachment to Target Cells

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Heparanase: Structure, Biological Functions, and Inhibition by Heparin-Derived Mimetics of Heparan Sulfate

Vlodavsky, I., Ilan, N., Naggi, A., & Casu, B. (2007) · Current Pharmaceutical Design · doi:10.2174/138161207781039742 · Cited by 277 · see citing works

Cell surface proteoglycan syndecan-1 mediates hepatocyte growth factor binding and promotes Met signaling in multiple myeloma

Derksen, P. W. B., Keehnen, R. M. J., Evers, L. M., van Oers, M. H. J., Spaargaren, M., & Pals, S. T. (2002) · Blood · doi:10.1182/blood.v99.4.1405 · Cited by 274 · see citing works

The TORrid affairs of viruses: effects of mammalian DNA viruses on the PI3K–Akt–mTOR signalling pathway

Buchkovich, N. J., Yu, Y., Zampieri, C. A., & Alwine, J. (2008) · Nature Reviews Microbiology · doi:10.1038/nrmicro1855 · Cited by 255 · see citing works

Epidermal growth factor receptor is a host-entry cofactor triggering hepatitis B virus internalization

Iwamoto, M., Saso, W., Sugiyama, R., Ishii, K., Ohki, M., Nagamori, S., Suzuki, R., Aizaki, H., Ryo, A., Yun, J.-H., et al. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1811064116 · Cited by 244 · see citing works

Heparanase: From basic research to therapeutic applications in cancer and inflammation

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Heparanase-enhanced shedding of syndecan-1 by myeloma cells promotes endothelial invasion and angiogenesis

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Heparanase Induces Vascular Endothelial Growth Factor Expression: Correlation with p38 Phosphorylation Levels and Src Activation

Zetser, A., Bashenko, Y., Edovitsky, E., Levy‐Adam, F., Vlodavsky, I., & Ilan, N. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-1811 · Cited by 234 · see citing works

Vascular Endothelial Growth Factor May Contribute to Increased Vascular Permeability in Acute Respiratory Distress Syndrome

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The pivotal role of phosphatidylinositol 3-kinase-Akt signal transduction in virus survival

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Heparanase Induces Endothelial Cell Migration via Protein Kinase B/Akt Activation

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Heparanase: busy at the cell surface

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Expression of interleukin 8 and not parathyroid hormone-related protein by human breast cancer cells correlates with bone metastasis in vivo.

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Heparanase regulation of cancer, autophagy and inflammation: new mechanisms and targets for therapy

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Hepatocyte growth factor and its receptor c-met in multiple myeloma

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The Related Adhesion Focal Tyrosine Kinase Is Tyrosine-phosphorylated after β1-Integrin Stimulation in B Cells and Binds to p130cas

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β1‐Integrins induce phosphorylation of Akt on serine 473 independently of focal adhesion kinase and Src family kinases

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PIKKing on PKB: regulation of PKB activity by phosphorylation

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Evidence for Direct Activation of mTORC2 Kinase Activity by Phosphatidylinositol 3,4,5-Trisphosphate

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Overview of Lymphoma Diagnosis and Management

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Activation of EGFR on monocytes is required for human cytomegalovirus entry and mediates cellular motility

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The TSC2/mTOR pathway drives endothelial cell transformation induced by the Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor

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Human Cytomegalovirus Protein UL38 Inhibits Host Cell Stress Responses by Antagonizing the Tuberous Sclerosis Protein Complex

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The role of epidermal growth factor receptor (EGFR) signaling in SARS coronavirus-induced pulmonary fibrosis

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Heparanase powers a chronic inflammatory circuit that promotes colitis-associated tumorigenesis in mice

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Cathepsin L Is Responsible for Processing and Activation of Proheparanase through Multiple Cleavages of a Linker Segment

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Heparanase: A Rainbow Pharmacological Target Associated to Multiple Pathologies Including Rare Diseases

Rivara, S., Milazzo, F. M., & Giannini, G. (2016) · Future Medicinal Chemistry · doi:10.4155/fmc-2016-0012 · Cited by 183 · see citing works

MicroRNA-1258 Suppresses Breast Cancer Brain Metastasis by Targeting Heparanase

Zhang, L., Sullivan, P. S., Goodman, J. C., Gunaratne, P. H., & Marchetti, D. (2011) · Cancer Research · doi:10.1158/0008-5472.can-10-1910 · Cited by 180 · see citing works

Heparanase Stimulation of Protease Expression Implicates It as a Master Regulator of the Aggressive Tumor Phenotype in Myeloma

Purushothaman, A., Chen, L., Yang, Y., & Sanderson, R. D. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m806266200 · Cited by 180 · see citing works

Heparanase mediates cell adhesion independent of its enzymatic activity

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VEGF-A expression by HSV-1–infected cells drives corneal lymphangiogenesis

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Molecular Genetic Analysis of Orf Virus: A Poxvirus That Has Adapted to Skin

Fleming, S. B., Wise, L. M., & Mercer, A. A. (2015) · Viruses · doi:10.3390/v7031505 · Cited by 163 · see citing works

Upregulated FoxM1 expression induced by hepatitis B virus X protein promotes tumor metastasis and indicates poor prognosis in hepatitis B virus-related hepatocellular carcinoma

Xia, L., Huang, W., Tian, D., Zhu, H., Zhang, Y., Hu, H., Fan, D., Nie, Y., & Wu, K. (2012) · Journal of Hepatology · doi:10.1016/j.jhep.2012.04.020 · Cited by 158 · see citing works

Inhibition of Influenza A Virus Infection by Fucoidan Targeting Viral Neuraminidase and Cellular EGFR Pathway

Wang, W., Wu, J., Zhang, X., Hao, C., Zhao, X., Jiao, G., Shan, X., Tai, W., & Yu, G. (2017) · Scientific Reports · doi:10.1038/srep40760 · Cited by 147 · see citing works

MAP-Kinase Regulated Cytosolic Phospholipase A2 Activity Is Essential for Production of Infectious Hepatitis C Virus Particles

Menzel, N., Fischl, W., Hueging, K., Bankwitz, D., Frentzen, A., Haid, S., Gentzsch, J., Kaderali, L., Bartenschlager, R. F. W., & Pietschmann, T. (2012) · PLoS Pathogens · doi:10.1371/journal.ppat.1002829 · Cited by 142 · see citing works

Hepatitis C Virus Induces Epidermal Growth Factor Receptor Activation via CD81 Binding for Viral Internalization and Entry

Diao, J., Pantua, H., Ngu, H., Kömüves, L. G., Diehl, L. J., Schaefer, G., & Kapadia, S. B. (2012) · Journal of Virology · doi:10.1128/jvi.00750-12 · Cited by 142 · see citing works

Phosphorylation of AKT: a Mutational Analysis

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Heparanase is a host enzyme required for herpes simplex virus-1 release from cells

Hadigal, S. R., Agelidis, A. M., Karasneh, G. A., Antoine, T. E., Yakoub, A. M., Ramani, V. C., Djalilian, A. R., Sanderson, R. D., & Shukla, D. (2015) · Nature Communications · doi:10.1038/ncomms7985 · Cited by 140 · see citing works

Constitutive mTORC1 activation by a herpesvirus Akt surrogate stimulates mRNA translation and viral replicationPreprint

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Inflammatory Cytokines and Fatty Acids Regulate Endothelial Cell Heparanase Expression

Chen, G., Wang, D., Vikramadithyan, R. K., Yagyu, H., Saxena, U., Pillarisetti, S., & Goldberg, I. J. (2004) · Biochemistry · doi:10.1021/bi0356552 · Cited by 130 · see citing works

Pathological processes activated by herpes simplex virus-1 (HSV-1) infection in the cornea

Koujah, L., Suryawanshi, R. K., & Shukla, D. (2018) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-018-2938-1 · Cited by 128 · see citing works

Macrophage Activation by Heparanase Is Mediated by TLR-2 and TLR-4 and Associates With Plaque Progression

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MEK inhibition impairs influenza B virus propagation without emergence of resistant variants

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Src Family Kinases Are Required for Integrin-mediated but Not for G Protein-coupled Receptor Stimulation of Focal Adhesion Kinase Autophosphorylation at Tyr-397

Salazar, E. P., & Rozengurt, E. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m100984200 · Cited by 124 · see citing works

HijAkt

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Molecular behavior adapts to context: heparanase functions as an extracellular matrix-degrading enzyme or as a T cell adhesion molecule, depending on the local pH.

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Epidermal Growth Factor Receptor-PI3K Signaling Controls Cofilin Activity To Facilitate Herpes Simplex Virus 1 Entry into Neuronal Cells

Zheng, K., Xiang, Y., Wang, X., Wang, Q., Zhong, M., Wang, S., Wang, X., Fan, J., Kitazato, K., & Wang, Y. (2014) · mBio · doi:10.1128/mbio.00958-13 · Cited by 118 · see citing works

The role of PI3K/Akt in human herpesvirus infection: From the bench to the bedside

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Heparanase: A Multitasking Protein Involved in Extracellular Matrix (ECM) Remodeling and Intracellular Events

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Heparanase Blockade as a Novel Dual-Targeting Therapy for COVID-19

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Role of Heparanase and Syndecan-1 in HSV-1 Release from Infected Cells

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Role of a Novel Heparanase Inhibitor on the Balance between Apoptosis and Autophagy in U87 Human Glioblastoma Cells

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Classification and Molecular Functions of Heparan Sulfate Proteoglycans and Their Molecular Mechanisms with the Receptor

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Heparanase Inhibitors in Cancer Progression: Recent Advances

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Protease, Growth Factor, and Heparanase-Mediated Syndecan-1 Shedding Leads to Enhanced HSV-1 Egress

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Non-enzymatic heparanase enhances gastric tumor proliferation via TFEB-dependent autophagy

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The association of telomere maintenance and TERT expression with susceptibility to human papillomavirus infection in cervical epithelium

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Elucidating the Consequences of Heparan Sulfate Binding by Heparanase 2

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Heparan Sulfate Binding Cationic Peptides Restrict SARS-CoV-2 Entry

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HPSE-mediated proinflammatory signaling contributes to neurobehavioral deficits following intranasal HSV-1 infection

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Heparan sulfate fine‐tunes stromal‐epithelial communication in the prostate gland

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Heparanase is a prognostic biomarker independent of tumor purity and hypoxia based on bioinformatics and immunohistochemistry analysis of esophageal squamous cell carcinoma

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Heparanase inhibitor OGT 2115 induces prostate cancer cell apoptosis via the downregulation of MCL‑1

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Curcumin protects extracellular matrix to maintain microenvironmental stability inhibiting colon cancer metastasis through HPSE/IL-6/STAT5 axis

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Role of heparanase in pulmonary hypertension

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Heparanase-Neutralizing Monoclonal Antibody (mAb A54) Attenuates Tumor Growth and Metastasis

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CMV Seropositive Status Increases Heparanase SNPs Regulatory Activity, Risk of Acute GVHD and Yield of CD34+ Cell Mobilization

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Heparanase Increases Podocyte Survival and Autophagic Flux after Adriamycin-Induced Injury

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Role of Heparanase in Pulmonary Arterial HypertensionPreprint

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Additional file 7 of Heparanase is a prognostic biomarker independent of tumor purity and hypoxia based on bioinformatics and immunohistochemistry analysis of esophageal squamous cell carcinoma

Wang, Y., Song, T., Li, K., Liu, H., Han, Y., Xu, T., Cao, F., Li, Y., & Yu, Y. (2022) · Figshare · doi:10.6084/m9.figshare.20329348

Splice Variant of Spalax Heparanase Skipping Exon 12

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Synthesis of Low‐Molecular‐Weight Fucoidan Analogue and Its Inhibitory Activities against Heparanase and SARS‐CoV‐2 Infection

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Integrated quantitative proteomics and phosphoproteomics analysis reveals USP46-POU4F1-HPSE signaling axis in the pathogenesis of Hirschsprung disease

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The Effect of a Novel Heparan Sulfate Mimetic on Inflammatory Migration Across the Blood-Brain Barrier Endothelium

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Additional file 3 of Heparanase is a prognostic biomarker independent of tumor purity and hypoxia based on bioinformatics and immunohistochemistry analysis of esophageal squamous cell carcinoma

Wang, Y., Song, T., Li, K., Liu, H., Han, Y., Xu, T., Cao, F., Li, Y., & Yu, Y. (2022) · Figshare · doi:10.6084/m9.figshare.20329336

Additional file 2 of Heparanase is a prognostic biomarker independent of tumor purity and hypoxia based on bioinformatics and immunohistochemistry analysis of esophageal squamous cell carcinoma

Wang, Y., Song, T., Li, K., Liu, H., Han, Y., Xu, T., Cao, F., Li, Y., & Yu, Y. (2022) · Figshare · doi:10.6084/m9.figshare.20329330

Additional file 1 of Heparanase is a prognostic biomarker independent of tumor purity and hypoxia based on bioinformatics and immunohistochemistry analysis of esophageal squamous cell carcinoma

Wang, Y., Song, T., Li, K., Liu, H., Han, Y., Xu, T., Cao, F., Li, Y., & Yu, Y. (2022) · Figshare · doi:10.6084/m9.figshare.20329327

Additional file 4 of Heparanase is a prognostic biomarker independent of tumor purity and hypoxia based on bioinformatics and immunohistochemistry analysis of esophageal squamous cell carcinoma

Wang, Y., Song, T., Li, K., Liu, H., Han, Y., Xu, T., Cao, F., Li, Y., & Yu, Y. (2022) · Figshare · doi:10.6084/m9.figshare.20329339

Additional file 5 of Heparanase is a prognostic biomarker independent of tumor purity and hypoxia based on bioinformatics and immunohistochemistry analysis of esophageal squamous cell carcinoma

Wang, Y., Song, T., Li, K., Liu, H., Han, Y., Xu, T., Cao, F., Li, Y., & Yu, Y. (2022) · Figshare · doi:10.6084/m9.figshare.20329342

Additional file 6 of Heparanase is a prognostic biomarker independent of tumor purity and hypoxia based on bioinformatics and immunohistochemistry analysis of esophageal squamous cell carcinoma

Wang, Y., Song, T., Li, K., Liu, H., Han, Y., Xu, T., Cao, F., Li, Y., & Yu, Y. (2022) · Figshare · doi:10.6084/m9.figshare.20329345

Precise Synthesis and Structure–Activity Relationship Studies of Low-Molecular-Weight Fucoidan Analogs

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Integrated 3D-QSAR and cellular profiling of sulfated and hydrophobic aminoglycoside glycans to modulate heparanase activity

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Heparanase, Endothelial Dysfunction, and Cardiovascular Risk: The Emerging Role of Vitamin D

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Identification of psoriasis-associated hub genes by integrated transcriptomics and machine learning

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Heparanase: A Multitasking Protein Involved in Extarcellular Matrix (ECM) Remodeling and Cellular SignalingPreprint

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Emerging Roles of Heparanase in Viral Pathogenesis

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Heparanase: A Multitasking Protein Involved in Extracellular Matrix (ECM) Remodeling and Intracellular Events

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Heparanase, Heparan Sulfate and Viral Infection

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