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Whole-genome analysis of TET dioxygenase function in regulatory T cells

Yue, X., Samaniego‐Castruita, D., González‐Avalos, E., Li, X., Barwick, B. G., & Rao, A. (2021) · EMBO Reports · doi:10.15252/embr.202152716 · Cited by 40 · see citing works

5-Hydroxymethylcytosine (5hmC), or How to Identify Your Favorite Cell

Ecsedi, S., Rodríguez‐Aguilera, J. R., & Hernández‐Vargas, H. (2018) · Epigenomes · doi:10.3390/epigenomes2010003 · Cited by 37 · see citing works

Tet2 coordinates with Foxo1 and Runx1 to balance T follicular helper cell and T helper 1 cell differentiation

Baessler, A., Novis, C. L., Shen, Z., Perovanović, J., Wadsworth, M. E., Thiede, K. A., Sircy, L. M., Harrison-Chau, M. H., Nguyen, N. X., Varley, K. E., et al. (2022) · Science Advances · doi:10.1126/sciadv.abm4982 · Cited by 38 · see citing works

Active DNA demethylation—The epigenetic gatekeeper of development, immunity, and cancer

Prasad, R. M., Yen, T. J., & Bellacosa, A. (2020) · Advanced Genetics · doi:10.1002/ggn2.10033 · Cited by 37 · see citing works

Epigenetic competition reveals density-dependent regulation and target site plasticity of phosphorothioate epigenetics in bacteria

Wu, X., Cao, B., Aquino, P., Chiu, T.-P., Chen, C., Jiang, S., Deng, Z., Chen, S., Rohs, R., Wang, L., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2002933117 · Cited by 34 · see citing works

Rare genetic variation at transcription factor binding sites modulates local DNA methylation profiles

Martin-Trujillo, A., Patel, N., Richter, F., Jadhav, B., Garg, P., Morton, S. U., McKean, D. M., DePalma, S. R., Goldmuntz, E., Gruber, D., et al. (2020) · PLoS Genetics · doi:10.1371/journal.pgen.1009189 · Cited by 32 · see citing works

Global DNA Methylation Analysis of Cancer-Associated Fibroblasts Reveals Extensive Epigenetic Rewiring Linked with RUNX1 Upregulation in Breast Cancer Stroma

Halperin, C., Hey, J., Weichenhan, D., Stein, Y., Mayer, S., Lutsik, P., Plass, C., & Scherz‐Shouval, R. (2022) · Cancer Research · doi:10.1158/0008-5472.can-22-0209 · Cited by 34 · see citing works

Complex impact of DNA methylation on transcriptional dysregulation across 22 human cancer types

Wang, Z., Yin, J., Zhou, W., Bai, J., Xie, Y., Xu, K., Zheng, X., Xiao, J. Y., Zhou, L., Qi, X., et al. (2020) · Nucleic Acids Research · doi:10.1093/nar/gkaa041 · Cited by 32 · see citing works

The RUNX1/RUNX1T1 network: translating insights into therapeutic options

Swart, L. E., & Heidenreich, O. T. (2020) · Experimental Hematology · doi:10.1016/j.exphem.2020.11.005 · Cited by 32 · see citing works

Role of TET dioxygenases in the regulation of both normal and pathological hematopoiesis

Joshi, K., Zhang, L., Breslin, P., Kini, A. R., & Zhang, J. (2022) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-022-02496-x · Cited by 30 · see citing works

Tet2 Regulates Osteoclast Differentiation by Interacting with Runx1 and Maintaining Genomic 5-Hydroxymethylcytosine (5hmC)

Chu, Y., Zhao, Z., Sant, D., Zhu, G., Greenblatt, S. M., Liu, L., Wang, J., Cao, Z., Tho, J. C., Shi, C., et al. (2018) · Genomics Proteomics & Bioinformatics · doi:10.1016/j.gpb.2018.04.005 · Cited by 29 · see citing works

5-methylcytosine turnover: Mechanisms and therapeutic implications in cancer

Turpin, M., & Salbert, G. (2022) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2022.976862 · Cited by 28 · see citing works

Dissecting TET2 Regulatory Networks in Blood Differentiation and Cancer

Lazarenkov, A., & Sardina, J. L. (2022) · Cancers · doi:10.3390/cancers14030830 · Cited by 25 · see citing works

Ascorbic Acid Promotes KIR Demethylation during Early NK Cell Differentiation

Wu, C., Zhang, B., Kim, H., Anderson, S. K., Miller, J. S., & Cichocki, F. M. (2020) · The Journal of Immunology · doi:10.4049/jimmunol.2000212 · Cited by 24 · see citing works

Involvement of brain‐derived neurotrophic factor methylation in the prefrontal cortex and hippocampus induced by chronic unpredictable mild stress in male mice

Cheng, S., Wang, W. T., Zhu, Z., Zhao, M., Li, H., Liu, D., & Pan, F. (2022) · Journal of Neurochemistry · doi:10.1111/jnc.15735 · Cited by 25 · see citing works

PU.1-Dependent Enhancer Inhibition Separates <i>Tet2</i> -Deficient Hematopoiesis from Malignant Transformation

Aivalioti, M. M., Bartholdy, B. A., Pradhan, K., Bhagat, T. D., Zintiridou, A., Jeong, J. J., Thiruthuvanathan, V. J., Pujato, M., Paranjpe, A., Zhang, C., et al. (2022) · Blood Cancer Discovery · doi:10.1158/2643-3230.bcd-21-0226 · Cited by 22 · see citing works

RUNX1-ETO: Attacking the Epigenome for Genomic Instable Leukemia

van der Kouwe, E., & Staber, P. B. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20020350 · Cited by 22 · see citing works

Targeting the CD74 signaling axis suppresses inflammation and rescues defective hematopoiesis in RUNX1 -familial platelet disorder

Mohammadhosseini, M., Enright, T., DuVall, A. S., Chitsazan, A., Lin, H., Ors, A., Davis, B. A., Nikolova, O. H., Bresciani, E., Diemer, J. L., et al. (2025) · Science Translational Medicine · doi:10.1126/scitranslmed.adn9832 · Cited by 21 · see citing works

TET1 Directs Chondrogenic Differentiation by Regulating SOX9 Dependent Activation of Col2a1 and Acan In Vitro

Smeriglio, P., Grandi, F. C., Taylor, S. E. B., Zalc, A., & Bhutani, N. (2020) · JBMR Plus · doi:10.1002/jbm4.10383 · Cited by 20 · see citing works

Gene Body Profiles of 5-Hydroxymethylcytosine: Potential Origin, Function and Use as a Cancer Biomarker

Pfeifer, G. P., & Szabó, P. E. (2018) · Epigenomics · doi:10.2217/epi-2018-0066 · Cited by 19 · see citing works

RUNX1/CEBPA Mutation in Acute Myeloid Leukemia Promotes Hypermethylation and Indicates for Demethylation Therapy

Romanova, E. I., Zubritskiy, A. V., Lioznova, A. V., Ogunleye, A. J., Golotin, V., Guts, A. A., Lennartsson, A., Demidov, O. N., & Medvedeva, Y. A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231911413 · Cited by 15 · see citing works

GATA6 is predicted to regulate DNA methylation in an in vitro model of human hepatocyte differentiation

Suzuki, T., Furuhata, E., Maeda, S., Kishima, M., Miyajima, Y., Tanaka, Y., Lim, J., Nishimura, H., Nakanishi, Y., Shojima, A., et al. (2022) · Communications Biology · doi:10.1038/s42003-022-03365-1 · Cited by 14 · see citing works

Interplay between epigenetic mechanisms and transcription factors in atherosclerosis

Aziz, M., Jandeleit-Dahm, K. A. M., & Khan, A. W. (2024) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2024.117615 · Cited by 12 · see citing works

Gadd45 Proteins in Immunity 2.0

Schmitz, I. (2022) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-94804-7_5 · Cited by 12 · see citing works

TET mediated epigenetic regulation of iNKT cell lineage fate choice and function

Tsagaratou, A. (2018) · Molecular Immunology · doi:10.1016/j.molimm.2018.08.020 · Cited by 10 · see citing works

Prediction of transcription factors associated with DNA demethylation during human cellular development

Miyajima, Y., Noguchi, S., Tanaka, Y., Li, J., Nishimura, H., Kishima, M., Lim, J., Furuhata, E., Suzuki, T., Kasukawa, T., et al. (2022) · Chromosome Research · doi:10.1007/s10577-022-09685-6 · Cited by 10 · see citing works

Emerging DNA Methylome Targets in FLT3-ITD-Positive Acute Myeloid Leukemia: Combination Therapy with Clinically Approved FLT3 Inhibitors

Tecik, M., & Adan, A. (2024) · Current Treatment Options in Oncology · doi:10.1007/s11864-024-01202-7 · Cited by 9 · see citing works

Aberrant OCIAD2 demethylation in lung adenocarcinoma is associated with outcome

Maki, M., Hong, J., Nakagawa, T., Kawai, H., Sakamoto, N., Sato, Y., & Noguchi, M. (2022) · Pathology International · doi:10.1111/pin.13262 · Cited by 9 · see citing works

Jumping translocations of chromosome 1q occurring by a multi-stage process in an acute myeloid leukemia progressed from myelodysplastic syndrome with a TET2 mutation

Lee, I., Gudipati, M. A., Waters, E., Duong, V. H., Baer, M. R., & Zou, Y. S. (2019) · Molecular Cytogenetics · doi:10.1186/s13039-019-0460-2 · Cited by 8 · see citing works

Target genes regulated by CLEC16A intronic region associated with common variable immunodeficiency

Huang, X., Huang, J., Li, X., Fan, J., Zhou, D., Qu, H., Glessner, J., Ji, D., Jia, Q., Ding, Z., et al. (2024) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2023.12.023 · Cited by 7 · see citing works

Establishment, Erasure and Synthetic Reprogramming of DNA Methylation in Mammalian Cells

Jurkowska, R. Z., & Jurkowski, T. P. (2019) · RNA technologies · doi:10.1007/978-3-030-14792-1_1 · Cited by 6 · see citing works

RUNX1 is a mediator of fibrotic activation and epigenetic memory in lung fibroblasts

Gilbert, R. M., Jones, D. L., Wellmerling, J. H., Caporarello, N., Meridew, J. A., Choi, K., Haak, A. J., Link, P. A., Tan, Q., Lee, J., et al. (2026) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1093/ajrcmb/aanag022 · Cited by 5 · see citing works

Identification of Epigenetic Regulatory Networks of Gene Methylation–miRNA–Transcription Factor Feed-Forward Loops in Basal-like Breast Cancer

Okano, L. M., de Azevedo, A. L. K., Carvalho, T. M., Resende, J., Magno, J. M., de Figueiredo, B. C., Malta, T. M., Castro, M. A. A., & Cavalli, L. R. (2025) · Cells · doi:10.3390/cells14161235 · Cited by 5 · see citing works

Distinct gene expression pattern of RUNX1 mutations coordinated by target repression and promoter hypermethylation in acute myeloid leukemia

Li, J., Jin, W. Y., Tan, Y., Wang, B., Wang, X., Zhao, M., & Wang, K. (2021) · Frontiers of Medicine · doi:10.1007/s11684-020-0815-4 · Cited by 5 · see citing works

Altering chromatin methylation patterns and the transcriptional network involved in regulation of hematopoietic stem cell fate

Shokouhian, M., Bagheri, M., Poopak, B., Chegeni, R., Davari, N., & Saki, N. (2020) · Journal of Cellular Physiology · doi:10.1002/jcp.29642 · Cited by 5 · see citing works

TET2/IDH1/2/WT1 and NPM1 Mutations Influence the RUNX1 Expression Correlations in Acute Myeloid Leukemia

Paşca, S., Jurj, A. M., Tomuleasa, C., & Zdrenghea, M. (2020) · Medicina · doi:10.3390/medicina56120637 · Cited by 4 · see citing works

DNA Methylation Patterns Associated with Tinnitus in Young Adults—A Pilot Study

Bhatt, I. S., Garay, J. A. R., Torkamani, A., & Dias, R. (2024) · Journal of the Association for Research in Otolaryngology · doi:10.1007/s10162-024-00961-2 · Cited by 4 · see citing works

FLI1 is associated with regulation of DNA methylation and megakaryocytic differentiation in FPDMM caused by a RUNX1 transactivation domain mutation

Tanaka, Y., Nakanishi, Y., Furuhata, E., Nakada, K.-I., Maruyama, R., Suzuki, H., & Suzuki, T. (2024) · Scientific Reports · doi:10.1038/s41598-024-64829-4 · Cited by 3 · see citing works

Transcription factor occupancy limits DNA methylation and determines ICAM1 expression in breast cancer

Chen, M., Zhou, Y., Fu, Z., & Wu, C. (2024) · Acta Biochimica et Biophysica Sinica · doi:10.3724/abbs.2024237 · Cited by 2 · see citing works

Multi-omics reveals rutin directly targets RUNX1 to disrupt the RUNX1/TET2 complex and alleviate NAFLD via TLR4/NF-κB inhibition

He, P., Luo, Z., 刘晓菊, Fang, F., Yan, Q., Liu, B., Chen, Z., Yu, Z., & Hou, T. (2026) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2026.178862 · Cited by 2 · see citing works

Hypomethylation of GCNT2 isoform A correlates with transcriptional expression and is associated with poor survival in acute myeloid leukemia

Wu, D., Qiu, H.-C., Xu, J., Lin, J., & Qian, J. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1490330 · Cited by 2 · see citing works

Advances in TET2 dioxygenase-mediated regulation of hematopoietic system development: physiological and pathological perspectives

Xie, J., Zhou, D., Shi, Y., & Xu, G. (2025) · Chinese Science Bulletin (Chinese Version) · doi:10.1360/tb-2025-0136 · Cited by 2 · see citing works

Mixed model-based eQTL analysis reveals lncRNAs associated with regulation of genes involved in sex determination and spermatogenesis: The key to understanding human gender imbalance

An, Y., & Lee, C. (2022) · Computational Biology and Chemistry · doi:10.1016/j.compbiolchem.2022.107713 · Cited by 1 · see citing works

Targeting RUNX1 Germline Variants: Agents Under Investigation

Ghalamkari, S., Hahn, C. N., Lau, A., Scott, H. S., Homan, C. C., & Brown, A. L. (2025) · Current Hematologic Malignancy Reports · doi:10.1007/s11899-025-00767-w · Cited by 1 · see citing works

Master Transcription Factors Regulate the DNA Methylation Landscape During Hepatocyte DifferentiationPreprint

Suzuki, T., Furuhata, E., Maeda, S., Kishima, M., Miyajima, Y., Tanaka, Y., Lim, J., Nishimura, H., Nakanish, Y., Shojima, A., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.12.16.423165 · Cited by 1 · see citing works

Lung injury epigenetically primes mesenchyme for amplified activation upon re-injuryPreprint

Jones, D. L., Caporarello, N., Meridew, J. A., Choi, K. M., Haak, A. J., Link, P. A., Tan, Q., Ördög, T., Ligresti, G., & Tschumperlin, D. J. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.03.04.483065

Faculty Opinions recommendation of Epigenetic competition reveals density-dependent regulation and target site plasticity of phosphorothioate epigenetics in bacteria.

Liu, P. (2021) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.738112360.793581587

The rescue of epigenomic abnormalities in ICF1 patient iPSCs following DNMT3B correction is incomplete at a residual fraction of H3K4me3-enriched regionsPreprint

Krishnan, V. P., Morone, B., Toubiana, S., Krzak, M., Strazzullo, M., Angelini, C., Selig, S., & Matarazzo, M. R. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.05.07.491011

Data from Global DNA Methylation Analysis of Cancer-Associated Fibroblasts Reveals Extensive Epigenetic Rewiring Linked with RUNX1 Upregulation in Breast Cancer Stroma

Halperin, C., Hey, J., Weichenhan, D., Stein, Y., Mayer, S., Lutsik, P., Plass, C., & Scherz‐Shouval, R. (2023) · doi:10.1158/0008-5472.c.6514163.v1 · Cited by 1 · see citing works

Data from PU.1-Dependent Enhancer Inhibition Separates Tet2-Deficient Hematopoiesis from Malignant Transformation

Aivalioti, M. M., Bartholdy, B., Pradhan, K., Bhagat, T. D., Zintiridou, A., Jeong, J. J., Thiruthuvanathan, V. J., Pujato, M. A., Paranjpe, A., Zhang, C., et al. (2023) · doi:10.1158/2643-3230.c.6550979

Data from PU.1-Dependent Enhancer Inhibition Separates Tet2-Deficient Hematopoiesis from Malignant Transformation

Aivalioti, M. M., Bartholdy, B., Pradhan, K., Bhagat, T. D., Zintiridou, A., Jeong, J. J., Thiruthuvanathan, V. J., Pujato, M. A., Paranjpe, A., Zhang, C., et al. (2023) · doi:10.1158/2643-3230.c.6550979.v1

DNA methylation analysis using RUNX1-mutated cells reveals association of FLI1 to familial platelet disorder with associated myeloid malignancies caused by a mutation in the transactivation domain of RUNX1Preprint

Tanaka, Y., Nakada, K.-I., Maruyama, R., Suzuki, H., & Suzuki, T. (2024) · Research Square · doi:10.21203/rs.3.rs-3939381/v1

CpG Traffic Lights Are Involved in Active DNA Demethylation

Lioznova, A. V., & Medvedeva, Y. A. (2024) · Molecular Biology · doi:10.1134/s0026893324090012

‘Nomadic’ Hematopoietic Stem Cells Navigate the Embryonic Landscape

Narayan, A. B., Hariom, S. K., Mukherjee, A. P., Das, D., Nair, A., & Nelson, E. J. R. (2025) · Stem Cell Reviews and Reports · doi:10.1007/s12015-025-10843-6

Associations of epigenetic aging with cortical thickness, brain age gaps, and neuroanatomical heterogeneityPreprint

Hermesdorf, M., Homann, J., Ernsting, J., Herrera-Rivero, M., Hahn, T., Lill, C. M., & Berger, K. (2025) · medRxiv · doi:10.1101/2025.11.09.25339844

Additional file 1 of Roles of TET and TDG in DNA demethylation in proliferating and non-proliferating immune cells

Onodera, A., González‐Avalos, E., Lio, C.-W. J., Georges, R. O., Bellacosa, A., Nakayama, T., & Rao, A. (2021) · Figshare · doi:10.6084/m9.figshare.14826131

Additional file 1 of Single-cell multimodal analysis identifies common regulatory programs in synovial fibroblasts of rheumatoid arthritis patients and modeled TNF-driven arthritis

Armaka, M., Konstantopoulos, D., Tzaferis, C., Lavigne, M. D., Σάκκου, Μ., Liakos, A., Sfikakis, P. P., Dimopoulos, M. A., Fousteri, M. I., & Kollias, G. (2022) · Figshare · doi:10.6084/m9.figshare.20374777

Additional file 5 of Roles of TET and TDG in DNA demethylation in proliferating and non-proliferating immune cells

Onodera, A., González‐Avalos, E., Lio, C.-W. J., Georges, R. O., Bellacosa, A., Nakayama, T., & Rao, A. (2021) · Figshare · doi:10.6084/m9.figshare.14826143

Additional file 3 of Pioneer transcription factors are associated with the modulation of DNA methylation patterns across cancers

Lemma, R. B., Fleischer, T., Martinsen, E., Ledsaak, M., Kristensen, V., Eskeland, R., Gabrielsen, O. S., & Mathelier, A. (2022) · Figshare · doi:10.6084/m9.figshare.19619310

Physicochemical features of intrinsically disordered regions predict DNA-demethylation-promoting activity of transcription factors

Qin, X., Sakamoto, Y., Wei, F., Nishimura, H., Nakanishi, Y., Maeda, S., & Suzuki, H. (2025) · Epigenetics & Chromatin · doi:10.1186/s13072-025-00655-w

Fibroblast memory Runx deep: epigenetic recall in pulmonary fibrosis

Kurche, J. S., & Redente, E. F. (2026) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1093/ajrcmb/aanag055

Molecular control of the Endothelial to Hematopoietic Transition

Khoury, H. (2019) · theses.fr (ABES) · doi:10.70675/6bd32be2zef78z4f8cz93c1z70512629d146

The TET-dependent DNA demethylation pathway is the driving force of hematopoiesisPreprint

Dvoriantchikova, G., Fleishaker, M., Barreras, H., Levy, R. B., & Ivanov, D. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.04.29.721744

Identification of elements determining KIR gene demethylation at the CD56-bright stage of NK cell development

Li, H., Koenigs, N. T., Ruesch, M., Troy, E. C., Brancato-Buentello, O., Sun, Z., Wu, X., Chen, X., Zhao, Y., Freud, A. G., et al. (2026) · iScience · doi:10.1016/j.isci.2026.117350

RUNX1 induces DNA replication independent active DNA demethylation at SPI1 regulatory regions

Goyal, S., Suzuki, T., Li, J., Maeda, S., Kishima, M., Nishimura, H., Shimizu, Y., & Suzuki, H. (2017) · BMC Molecular Biology · doi:10.1186/s12867-017-0087-y · Cited by 7 · see citing works

DNA methylation of Runx1 regulatory regions correlates with transition from primitive to definitive hematopoietic potential in vitro and in vivo

Webber, B. R., Iacovino, M., Choi, S. H., Tolar, J., Kyba, M., & Blazar, B. R. (2013) · Blood · doi:10.1182/blood-2013-03-489369 · Cited by 23 · see citing works

DNA Methylation Profile of Runx1 Regulatory Regions Is Correlated with Transition From Primitive to Definitive Hematopoietic Potential In Vitro and In Vivo

Webber, B. R., Iacovino, M., Kyba, M., Blazar, B. R., & Tolar, J. (2011) · Blood · doi:10.1182/blood.v118.21.389.389

3049 – DECRYPTING RUNX1’S DUAL HEMATOPOIETIC ROLES VIA SPATIAL MOTIF CRYPTOGRAPHY AND EPIGENETIC PLASTICITY

Liu, S., Lu, T., Yang, L., Qi, B., & Yen, K. (2025) · Experimental Hematology · doi:10.1016/j.exphem.2025.104990

Chromatin regulation by RUNX1

Lichtinger, M., Hoogenkamp, M., Krysinska, H., Ingram, R., & Bonifer, C. (2010) · Blood Cells Molecules and Diseases · doi:10.1016/j.bcmd.2010.02.009 · Cited by 24 · see citing works