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Cited by 369

The DOI matches its Crossref record; 229 of the 229 references it cites were found in a registry or an index.

Molecular mechanisms of cardiovascular disease in OSAHS: the oxidative stress link

Open access
Lavie, L., Lavie, P.·2009·European Respiratory Journal
DOI 10.1183/09031936.00086608
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Abstract

Obstructive sleep apnoea/hypopnoea syndrome (OSAHS) is a highly prevalent breathing disorder in sleep that is an independent risk factor for cardiovascular morbidity and mortality. A large body of evidence, including clinical studies and cell culture and animal models utilising intermittent hypoxia, delineates the central role of oxidative stress in OSAHS as well as in conditions and comorbidities that aggregate with it. Intermittent hypoxia, the hallmark of OSAHS, is implicated in promoting the formation of reactive oxygen species (ROS) and inducing oxidative stress. The ramifications of increased ROS formation are pivotal. ROS can damage biomolecules, alter cellular functions and function as signalling molecules in physiological as well as in pathophysiological conditions. Consequently, they promote inflammation, endothelial dysfunction and cardiovascular morbidity. Oxidative stress is also a crucial component in obesity, sympathetic activation and metabolic disorders such as hypertension, dyslipidaemia and type 2 diabetes/insulin resistance, which aggregate with OSAHS. These conditions and comorbidities could result directly from the oxidative stress that is characteristic of OSAHS or could develop independently. Hence, oxidative stress represents the common underlying link in OSAHS and the conditions and comorbidities that aggregate with it.

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Crossref · 10.1183/09031936.00086608

Cites

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Citations

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Metadata

Authors
Lavie, L., & Lavie, P.
Venue
European Respiratory Journal
Publisher
European Respiratory Society (ERS)
Published
2009-05-29
Volume
33
Issue
6
Pages
1467-1484
ISSN
  • 0903-1936 (ISSN-L)
  • 1399-3003
DOI
10.1183/09031936.00086608
OpenAlex
W2151624371
Cited by
369
References
229
FWCI
15.75
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Molecular mechanisms of cardiovascular disease in OSAHS: the oxidative stress link. https://app.cochat.ai/papers/10.1183/09031936.00086608
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Lavie, L., & Lavie, P. (2009). Molecular mechanisms of cardiovascular disease in OSAHS: the oxidative stress link. European Respiratory Journal. https://doi.org/10.1183/09031936.00086608

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.