The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
Genes, environments, development and asthma: a reappraisal
Open accessAbstract
Significant advances have been made in our understanding of the role of genetic variation in determining complex human phenotypes such as asthma. It is now well established that there is no single “gene for asthma”, in the way that the cystic fibrosis transmembrane receptor is the “gene for cystic fibrosis”. It is also clear that among all genetic variants eventually found to be associated with asthma, only a few will be replicated, and in the same direction, in the majority of well-performed studies. Current evidence suggests that most asthma-related polymorphisms determine risk for the disease in a context-dependent manner,i.e. they interact with environmental factors, with polymorphisms in other genes and with the specific developmental phase of the disease in which the association is tested. Elucidating these complex interactions will allow us to understand better the heterogeneity of the disease and thus to develop therapeutic tools tailored to the specific form of the disease in each patient.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Asthma and Wheezing in the First Six Years of Life
Martinez, F. D., Wright, A. L., Taussig, L. M., Holberg, C. J., Halonen, M., & Morgan, W. J. (1995) · New England Journal of Medicine · doi:10.1056/nejm199501193320301 · Cited by 3,823
Phenotypic evolution: a reaction norm perspective
(1999) · Choice Reviews Online · doi:10.5860/choice.36-4478 · Cited by 1,836
Problems of reporting genetic associations with complex outcomes
Colhoun, H. M., McKeigue, P. M., & Smith, G. D. (2003) · The Lancet · doi:10.1016/s0140-6736(03)12715-8 · Cited by 1,204
Baldini, M., Carla Lohman, I., Halonen, M., Erickson, R. P., Holt, P. G., & Martinez, F. D. (1999) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.20.5.3494 · Cited by 835
Self-citationHull, J. (2000) · Thorax · doi:10.1136/thorax.55.12.1023 · Cited by 515
Graves, P. E., Kabesch, M., Halonen, M., Holberg, C. J., Baldini, M., Fritzsch, C., Weiland, S. K., Erickson, R. P., von Mutius, E., & Martinez, F. D. (2000) · Journal of Allergy and Clinical Immunology · doi:10.1067/mai.2000.104940 · Cited by 410
Self-citationA Second-Generation Genomewide Screen for Asthma-Susceptibility Alleles in a Founder Population
Ober, C., Tsalenko, A., Parry, R., & Cox, N. J. (2000) · The American Journal of Human Genetics · doi:10.1016/s0002-9297(07)62946-2 · Cited by 357
LeVan, T. D., Bloom, J. W., Bailey, T. J., Karp, C. L., Halonen, M., Martinez, F. D., & Vercelli, D. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.10.5838 · Cited by 352
Self-citationGene-Gene Interaction in Asthma: IL4RA and IL13 in a Dutch Population with Asthma
Howard, T. D., Koppelman, G. H., Xu, J., Zheng, S. L., Postma, D. S., Meyers, D. A., & Bleecker, E. R. (2002) · The American Journal of Human Genetics · doi:10.1086/338242 · Cited by 337
Epistasis and balanced polymorphism influencing complex trait variation
Kroymann, J., & Mitchell-Olds, T. (2005) · Nature · doi:10.1038/nature03480 · Cited by 274
Cited by
The exposome: a new paradigm to study the impact of environment on health
Vrijheid, M. (2014) · Thorax · doi:10.1136/thoraxjnl-2013-204949 · Cited by 351
Therapeutic Potential of Volatile Terpenes and Terpenoids from Forests for Inflammatory Diseases
Kim, T., Song, B., Cho, K. S., & Lee, I.-S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21062187 · Cited by 281
Metadata
- Authors
- Martinez, F. D.
- Venue
- European Respiratory Journal
- Publisher
- European Respiratory Society (ERS)
- Published
- 2006-12-29
- Volume
- 29
- Issue
- 1
- Pages
- 179-184
- ISSN
- 0903-1936 (ISSN-L)
- 1399-3003
- OpenAlex
- W2020722855
- Cited by
- 259
- References
- 21
- FWCI
- 6.08
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Genes, environments, development and asthma: a reappraisal. https://app.cochat.ai/papers/10.1183/09031936.00087906
- The paper
- Martinez, F. D. (2007). Genes, environments, development and asthma: a reappraisal. European Respiratory Journal. https://doi.org/10.1183/09031936.00087906
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
