Chronic cough in patients with sleep-disordered breathing
Open accessAbstract
Chronic cough can be the sole presenting symptom for patients with obstructive sleep apnoea. We investigated the prevalence, severity and factors associated with chronic cough in patients with sleep-disordered breathing (SDB). We invited 108 consecutive patients who had been referred for evaluation of SDB to complete a comprehensive questionnaire on respiratory and sleep health, which included the Leicester Cough Questionnaire (cough specific quality of life; LCQ), Epworth Sleepiness Scale (ESS) and the Mayo Clinic gastro-oesophageal questionnaire. Chronic cough was defined as cough for a duration of >2 months. 33% of patients with SDB reported a chronic cough. Patients with a chronic cough had impaired cough related-quality of life affecting all health domains (mean±sem LCQ score 17.7±0.7; normal = 21). Patients with SDB and chronic cough were predominantly females (61%versus 17%; p<0.001) and reported more nocturnal heartburn (28%versus 5%; p = 0.03) and rhinitis (44%versus 14%; p = 0.02) compared to those without SDB. There were no significant differences in ESS, respiratory disturbance index, body mass index, or symptoms of breathlessness, wheeze, snoring, dry mouth and choking between those with cough and those without. Chronic cough is prevalent in patients with SDB and is associated with female sex, symptoms of nocturnal heartburn and rhinitis. Further studies are required to investigate the impact of continuous positive airway pressure therapy on cough associated with SDB to explore the mechanism of this association.
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Numerous studies have established a high incidence of gastroesophageal reflux disease among patients with sleep-disordered breathing.
“Numerous studies have established a high incidence of GERD among patients with SDB.923–936”
From International Consensus Statement on Obstructive Sleep Apnea (2023) · cites this paper as [925]
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International Consensus Statement on Obstructive Sleep Apnea
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- Authors
- Chan, K. K. Y., Ing, A. J., Laks, L., Cossa, G., Rogers, P., & Birring, S. S.
- Affiliations
- King's College Hospital (GB)
- Camden and Campbelltown Hospitals (AU)
- Concord Repatriation General Hospital (AU)
- Venue
- European Respiratory Journal
- Publisher
- European Respiratory Society (ERS)
- Published
- 2010-02
- Volume
- 35
- Issue
- 2
- Pages
- 368-372
- ISSN
- 0903-1936 (ISSN-L)
- 1399-3003
- OpenAlex
- W2103345459
- Semantic Scholar
- bce19ada60af4702731e881b6db8913172555a4e
- Cited by
- 90
- References
- 42
- Citations by year
- 2026: 6 · 2025: 3 · 2024: 9 · 2023: 7 · 2022: 6 · 2021: 8 · 2020: 5 · 2019: 5 · 2018: 5 · 2017: 2 · 2016: 3 · 2015: 6 · 2014: 5 · 2013: 5 · 2012: 4
- FWCI
- 5.33
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- European Respiratory Journal (publishedVersion)
- PubMed (publishedVersion)
- Research Portal (King's College London) (submittedVersion)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Respiratory and Cough-Related Research
- Health Sciences › Medicine › Physiology › Obstructive Sleep Apnea Research
- Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
- Keywords
- chronic cough, sleep-disordered breathing, obstructive sleep apnea, cough-related quality of life, Leicester Cough Questionnaire, nocturnal heartburn, rhinitis, sex differences, prevalence, continuous positive airway pressure
- MeSH terms
- Adult, Aged, Chronic Disease, Cough, Female, Humans, Male, Middle Aged, Quality of Life, Surveys and Questionnaires, Severity of Illness Index, Sleep Apnea Syndromes, Snoring, Prevalence, Polysomnography
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