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Cited by 660Chronic Obstructive Pulmonary Disease (COPD) ResearchAsthma and respiratory diseasesSmoking Behavior and Cessation

The DOI matches its Crossref record; 138 of the 139 references it cites were found in a registry or an index.

Complex chronic comorbidities of COPD

Open access
Fabbri, L. M., Luppi, F., Beghé, B., Rabe, K. F.·2008·European Respiratory Journal
DOI 10.1183/09031936.00114307
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Abstract

Chronic obstructive pulmonary disease (COPD) is defined by fixed airflow limitation associated with an abnormal pulmonary and systemic inflammatory response of the lungs to cigarette smoke. The systemic inflammation induced by smoking may also cause chronic heart failure, metabolic syndrome and other chronic diseases, which may contribute to the clinical manifestations and natural history of COPD. Thus COPD can no longer be considered a disease only of the lungs, as it is often associated with a wide variety of systemic consequences. A better understanding of the origin and consequences of systemic inflammation, and of potential therapies, will most likely lead to better care of patients with COPD. Medical textbooks and clinical guidelines still largely ignore the fact that COPD seldom occurs in isolation. As the diagnosis and assessment of severity of COPD may be greatly affected by the presence of comorbid conditions, the current authors believe that lung function measurement, noninvasive assessment of cardiovascular and metabolic functions, and circulating inflammatory markers (e.g. C-reactive protein) might help to better characterise these patients. Similarly, preventive and therapeutic interventions should address the patient in their complexity.

Overview

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Registry

Crossref · 10.1183/09031936.00114307

Cites

138 of 138 references verified0 citation errors · 0 not checkable

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Citations

Cites

Research works printed but not linked: 8

  1. Fabbri LM, Rabe KF. Complexity of patients with multiple chronic diseases. Proceedings of an ERS Research Seminar (Rome, February 11–12, 2007). www.ersnet.org/ers/lr/browse/default.aspx?id_dossier = 67422 Date last accessed: October 31, 2007.
  2. 2005, Exp Lung Res, 31, 72
  3. 2007, Curr Opin Pulm Med, 13, 114
  4. 1996, Diabetes Metab, 22, 37
  5. 2000, Am J Respir Crit Care Med, 161, A583
  6. 2006, Cardiovasc Res, 3, e333
  7. 2005, Cochrane Database Syst Rev, 3, CD005374
  8. 2007, Curr Opin Pulm Med, 13, 90

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Metadata

Authors
Fabbri, L. M., Luppi, F., Beghé, B., & Rabe, K. F.
Affiliations
University of Modena and Reggio Emilia (IT)
ORCID
Venue
European Respiratory Journal
Publisher
European Respiratory Society (ERS)
Published
2007-12-31
Volume
31
Issue
1
Pages
204-212
ISSN
  • 0903-1936 (ISSN-L)
  • 1399-3003
DOI
10.1183/09031936.00114307
OpenAlex
W2165340553
Cited by
660
References
139
Citations by year
2026: 8 · 2025: 16 · 2024: 20 · 2023: 17 · 2022: 26 · 2021: 19 · 2020: 35 · 2019: 25 · 2018: 36 · 2017: 48 · 2016: 31 · 2015: 50 · 2014: 68 · 2013: 55 · 2012: 59
FWCI
28.24
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • European Respiratory Journal (publishedVersion)
  • PubMed (publishedVersion)
  • BOA (University of Milano-Bicocca) (submittedVersion)
  • IRIS UNIMORE (University of Modena and Reggio Emilia) (submittedVersion, cc-by)
  • INFM-OAR (INFN Catania) (submittedVersion, other-oa)
Topics
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Asthma and respiratory diseases
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Smoking Behavior and Cessation
Keywords
chronic obstructive pulmonary disease, comorbidities, systemic inflammation, chronic heart failure, metabolic syndrome, cigarette smoking, C-reactive protein, inflammatory markers, COPD severity assessment, cardiovascular function, COPD management
MeSH terms
Chronic Disease, Health Status, Humans, Inflammation, Lung, Models, Biological, Prognosis, Risk Factors, Smoking, Pulmonary Medicine, Comorbidity, Guidelines as Topic, Pulmonary Disease, Chronic Obstructive, Overweight

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