Cited by 1,052Chronic Obstructive Pulmonary Disease (COPD) ResearchAsthma and respiratory diseasesSmoking Behavior and Cessation

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Mortality in COPD: role of comorbidities

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Sin, D. D., Anthonisen, N. R., Soriano, J. B., Agusti, A. G.·2006·European Respiratory Journal

DOI 10.1183/09031936.00133805

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Abstract

Chronic obstructive pulmonary disease (COPD) represents an increasing burden throughout the world. COPD-related mortality is probably underestimated because of the difficulties associated with identifying the precise cause of death. Respiratory failure is considered the major cause of death in advanced COPD. Comorbidities such as cardiovascular disease and lung cancer are also major causes and, in mild-to-moderate COPD, are the leading causes of mortality. The links between COPD and these conditions are not fully understood. However, a link through the inflammation pathway has been suggested, as persistent low-grade pulmonary and systemic inflammation, both known risk factors for cardiovascular disease and cancer, are present in COPD independent of cigarette smoking. Lung-specific measurements, such as forced expiratory volume in one second (FEV(1)), predict mortality in COPD and in the general population. However, composite tools, such as health-status measurements (e.g. St George's Respiratory Questionnaire) and the BODE index, which incorporates Body mass index, lung function (airflow Obstruction), Dyspnoea and Exercise capacity, predict mortality better than FEV(1) alone. These multidimensional tools may be more valuable because, unlike predictive approaches based on single parameters, they can reflect the range of comorbidities and the complexity of underlying mechanisms associated with COPD. The current paper reviews the role of comorbidities in chronic obstructive pulmonary disease mortality, the putative underlying pathogenic link between chronic obstructive pulmonary disease and comorbid conditions (i.e. inflammation), and the tools used to predict chronic obstructive pulmonary disease mortality.

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A new method of classifying prognostic comorbidity in longitudinal studies: Development and validation
Charlson, M. E., Pompei, P., Ales, K. L., & MacKenzie, C. R. (1987) · Journal of Chronic Diseases · doi:10.1016/0021-9681(87)90171-8 · Cited by 49,742
Atherosclerosis--an inflammatory disease
Ross, R. (1999) · New England Journal of Medicine · doi:10.1056/nejm199901143400207 · Cited by 21,725
Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Pulmonary Disease
Vestbo, J., Hurd, S. S., Agustí, A. G., Jones, P. W., Vogelmeier, C., Anzueto, A., Barnes, P. J., Fabbri, L. M., Martinez, F. J., Nishimura, M., et al. (2013) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201204-0596pp · Cited by 15,983
Projections of Global Mortality and Burden of Disease from 2002 to 2030
Mathers, C. D., & Loncar, D. (2006) · PLoS Medicine · doi:10.1371/journal.pmed.0030442 · Cited by 11,386
Adapting a clinical comorbidity index for use with ICD-9-CM administrative databases
DEYO, R. (1992) · Journal of Clinical Epidemiology · doi:10.1016/0895-4356(92)90133-8 · Cited by 10,452
Alternative projections of mortality and disability by cause 1990–2020: Global Burden of Disease Study
Murray, C. J. L., & López, A. D. (1997) · The Lancet · doi:10.1016/s0140-6736(96)07492-2 · Cited by 7,007
Atherosclerosis
Lusis, A. J. (2000) · Nature · doi:10.1038/35025203 · Cited by 4,880
Standards for the diagnosis and treatment of patients with COPD: a summary of the ATS/ERS position paper
Celli, B. R., MacNee, W., Agustí, A. G. N., Anzueto, A. R., Berg, B., Buist, A. S., Calverley, P. M., Chavannes, N. H., Dillard, T. A., Fahy, B. F., et al. (2004) · European Respiratory Journal · doi:10.1183/09031936.04.00014304 · Cited by 4,405
The body-mass index, airflow obstruction, dyspnea, and exercise capacity index in chronic obstructive pulmonary disease
Celli, B. R., Cote, C. G., Marin, J. M., Casanova, C., Montes de Oca, M., Mendez, R. A., Pinto Plata, V., & Cabral, H. J. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa021322 · Cited by 4,015
The Nature of Small-Airway Obstruction in Chronic Obstructive Pulmonary Disease
Hogg, J. C., Chu, F. S. F., Utokaparch, S., Woods, R. R., Elliott, W. M., Buzatu, L., Cherniack, R. M., Rogers, R. M., Sciurba, F. C., Coxson, H. O., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa032158 · Cited by 3,828

Show all 142 references

Research works printed but not linked: 11

1997, Monaldi Arch Chest Dis, 52, 43
1998, Monaldi Arch Chest Dis, 53, 324
1999, Eur Respir J, 14, 387s
10.1001/jama.1994.03520190043033 · DOI
2000, J Am Geriatr Soc, 48, S91
European Respiratory Society, European Lung Foundation. Loddenkemper R, Gibson GJ, Sibille Y, eds. Lung Health in Europe Facts and Figures. Sheffield, ERSJ, 2003; pp. 34–43
2004, Chest, 125, 134S
1998, Int J Mol Med, 2, 715
2001, Chest, 119, 1294
1995, Oncogene, 11, 999
1978, Scand J Respir Dis, 59, 154

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Juang, Y. R., Lim, L., Chotirmall, S., Abisheganaden, J., Koh, M., Tsai, M.-J., Liew, M. F., Yii, A., Tiew, P. Y., Price, D. B., et al. (2026) · International Journal of COPD · doi:10.2147/copd.s563620 · Cited by 6
ANXIETY AND DEPRESSIVE DISORDERS IN COMORBID CHRONIC OBSTRUCTIVE PULMONARY DISEASE AND HYPERTENSION
Kozlov, E. V. (2014) · Siberian medical review · doi:10.20333/25000136-2014-1-19-25 · Cited by 2
呼吸リハビリテーションに関するステートメント日本呼吸ケア・リハビリテーション学会,日本呼吸理学療法学会,日本呼吸器学会
純, 植., 玲, 神., 徹郎, 大., 秀樹, 桂., 一, 黒., 守秀, 安., 裕子, 佐., 佐野恵美香, 石川朗, 高橋, 仁., et al. (2018) · 日本呼吸ケア・リハビリテーション学会誌 · doi:10.15032/jsrcr.27.2_95 · Cited by 2
Association of COPD with osteoporosis in male smokers: A case control study in a tertiary medical college hospital in Bangladesh
Bari, M. Z. J., Patwary, M. I., Hussain, D., Islam, S. A. H. M. M., & Rasker, J. J. (2019) · Journal of Back and Musculoskeletal Rehabilitation · doi:10.3233/bmr-181303 · Cited by 2
Evaluation of the correlation between perfusion index and prognosis in patients with chronic obstructive pulmonary disease
Demir, M., Cander, B., & Ayvacı, B. M. (2021) · The European Research Journal · doi:10.18621/eurj.814761 · Cited by 2
Transcriptomic analysis reveals distinct effects of cigarette smoke on murine airspace and bone-marrow derived macrophages
Faherty, L., Zhang, W. Z., Salih, M. M., Robinson, E. K., Perez, E., Kim, K., Carpenter, S. B., & Cloonan, S. M. (2024) · Respiratory Research · doi:10.1186/s12931-024-02939-3 · Cited by 2
An Italian Delphi Consensus on the Triple inhalation Therapy in Chronic Obstructive Pulmonary Disease
Solidoro, P., Dente, F. L., Micheletto, C., Pappagallo, G. L., Pelaia, G., & Papi, A. A. (2024) · Multidisciplinary Respiratory Medicine · doi:10.5826/mrm.2024.949 · Cited by 2
Incident Cardiometabolic Comorbidities in Smokers with/Without Chronic Obstructive Pulmonary Disease: A Long-Term Cohort Study
Herrero‐Cortina, B., Maldonado-Guaje, A., Rodríguez-Sanz, J., Boldova, A., Cubero-Marín, P., Marín‐Oto, M., Sánz-Rubio, D., & Marín, J. M. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13247627 · Cited by 2
VON WILLEBRAND FACTOR AND ITS ROLE IN ENDOTHELIAL DYSFUNCTION IN CORONARY HEART DISEASE
Verigo, Y. I., Демко, И. В., Petrova, M. M., Sobko, E. A., & Геннадьевна, М. М. (2014) · Siberian medical review · doi:10.20333/25000136-2014-5-23-28 · Cited by 2
Relationship between Air Pollution and Hospital Admissions for Chronic Obstructive Pulmonary Disease in Changchun, China: A Season-Stratified Case-Cross Study
Ju, Y., Ma, X., Li, H., Liu, S., Liya, A., & Guo, X. (2021) · Canadian Respiratory Journal · doi:10.1155/2021/3240785 · Cited by 2
The Importance of Chronic Bronchitis in Chronic Obstructive Pulmonary Disease
Sapey, E., & Robert, A. (2011) · InTech eBooks · doi:10.5772/18116 · Cited by 2
Investigation of Relationship between Comorbid Factors and Excessive Dynamic Airway Collapse and Frequency of Hospitalization in Frequently Hospitalized COPD Patients
Yarkın, T., Ağca, M., Acar, G., Göl, G., Tokgöz, F., & Baran, R. (2014) · Eurasian Journal of Pulmonology · doi:10.5152/ejp.2014.66934 · Cited by 2
Chronic heart failure modifies the response to positive end-expiratory pressure in patients with chronic obstructive pulmonary disease
Bihari, S., & Bersten, A. D. (2012) · Journal of Critical Care · doi:10.1016/j.jcrc.2012.03.012 · Cited by 2
COPD Exacerbations: An Evidence-Based Review
Robbins, R. (2012) · DOAJ (DOAJ: Directory of Open Access Journals) · Cited by 2
[Endocrinometabolic disorders in chronic obstructive pulmonary disease].
Torres‐Sánchez, I., Valenza, M. C., Fernando Carrasco, N., Martos, I. C., Valenza‐Demet, G., & Cano-Capellaci, M. (2013) · PubMed · doi:10.3305/nh.2013.28.4.6573 · Cited by 2
Correlation Between COPD And Echocardiographic Features With Severity Of Disease.
Gupta, R., & Mann, S. (2016) · National journal of integrated research in medicine · Cited by 2
Expertentreffen obstruktive Atemwegserkrankungen: Kardiovaskuläre Aspekte der COPD
Lorenz, J., Bals, R., MAGNUSSEN, H., Pfeifer, M. A., Randerath, W. J., Steinkamp, G., Taube, C., Teschler, H., Vogelmeier, C. F., Welte, T., et al. (2013) · Pneumologie · doi:10.1055/s-0033-1344642 · Cited by 2
Symptômes et histoire naturelle de la BPCO : rôle des voies aérienne distales
Chaouat, A., Chabot, F., & Dusser, D. J. (2011) · Revue des Maladies Respiratoires · doi:10.1016/j.rmr.2011.08.004 · Cited by 2
The use of multidimensional indices
Celli, B. R., & Macario, C. C. (2015) · European Respiratory Society eBooks · doi:10.1183/2312508x.10019714 · Cited by 2
Integrating the care of the complex COPD patient
Donner, C. F., Carrozzi, L., Maio, S., Baldacci, S., Pistelli, F., Viegi, G., Purro, A., Torchio, R., Clini, E. M., Amaducci, S., et al. (2017) · Monaldi Archives for Chest Disease · doi:10.4081/monaldi.2017.786 · Cited by 2
Anti-inflammatory Effects of Telmisartan and Valsartan in Animal Model of Airways Inflammation
Hussain, S. A., Algaem, M. A., & Numan, I. T. (2014) · Pharmacologia · doi:10.5567/pharmacologia.2014.149.154 · Cited by 2
Factors affecting the development of airflow limitation among South Korean smokers
Kim, Y., & Cho, W. (2019) · Tobacco Induced Diseases · doi:10.18332/tid/103088 · Cited by 2
Metabolic syndrome; frequency and its relationship with variable parameters in chronic obstructive pulmonary disease
Said, A. F., Mohamed, B. I., Abdelnaem, E. A., & Ismail, A. S. (2019) · Egyptian Journal of Bronchology · doi:10.4103/ejb.ejb_51_18 · Cited by 2
Verarbeitung von Daten aus Leichenschau, Sektion und Epikrise für ein Nationales Mortalitätsregister
Mueller, U. O., & Werdecker, A. (2019) · Springer eBooks · doi:10.1007/978-3-662-57842-1_11 · Cited by 2
Glomerular filtration rate in patients with obstructive sleep apnea: the influence of cystatin-C-based estimations and comorbidity
Nowiński, A., Czyżak-Gradkowska, A., Jończak, L., Korzybski, D., Peradzyńska, J., Pływaczewski, R., & Śliwiński, P. (2020) · Journal of Thoracic Disease · doi:10.21037/jtd.2020.02.11 · Cited by 2
Challenges and Pitfalls of Using Repeat Spirometry Recordings in Routine Primary Care Data to Measure FEV1 Decline in a COPD Population
Whittaker, H. R., Kiddle, S. J., & Quint, J. K. (2021) · Pragmatic and Observational Research · doi:10.2147/por.s319965 · Cited by 2
Nutrition status and obesity paradox in chronic obstructive pulmonary disease
Drapkina, O. M., Avdeev, S. N., Budnevsky, A. V., Ovsyannikov, Е. S., Васильевна, К. А., & Дробышева, Е. С. (2021) · Voprosy Pitaniya · doi:10.33029/0042-8833-2021-90-6-42-49 · Cited by 2
Cardiovascular Disease
Troosters, T. (2011) · Humana Press eBooks · doi:10.1007/978-1-60761-673-3_4 · Cited by 2
Health Care Utilization and Costs After Initiating Budesonide/Formoterol Combination or Fluticasone/Salmeterol Combination Among COPD Patients New to ICS/LABA Treatment
Davis, J. R., Kern, D. M., Williams, S. A., Tunceli, O., Wu, B., Hollis, S., Strange, C., & Trudo, F. J. (2016) · Journal of Managed Care & Specialty Pharmacy · doi:10.18553/jmcp.2016.15127 · Cited by 2
Hospitalization increases while economic status deteriorates in late stages of chronic obstructive pulmonary disease: the Korean National Health and Nutrition Examination Survey for 2007–2015
Kang, H. K., Jung, J., Kang, M., Kim, D. K., Choi, H., Cho, Y., Jang, S. H., Lee, C., Oh, Y., Park, J., et al. (2021) · Journal of Thoracic Disease · doi:10.21037/jtd-20-2683 · Cited by 2

Authors: Sin, D. D., Anthonisen, N. R., Soriano, J. B., & Agusti, A. G.
Affiliations: St. Paul's Hospital (CA)
London School of Hygiene & Tropical Medicine (GB)
ORCID: Sin, D. D.
Soriano, J. B.
Venue: European Respiratory Journal
Publisher: European Respiratory Society (ERS)
Published: 2006-11-30
Volume: 28
Issue: 6
Pages: 1245-1257
ISSN: 0903-1936 (ISSN-L)
1399-3003
DOI: 10.1183/09031936.00133805
OpenAlex: W2118228748
Cited by: 1,052
References: 142
Citations by year: 2026: 22 · 2025: 44 · 2024: 43 · 2023: 40 · 2022: 36 · 2021: 60 · 2020: 61 · 2019: 55 · 2018: 61 · 2017: 63 · 2016: 76 · 2015: 61 · 2014: 77 · 2013: 74 · 2012: 51
FWCI: 7.69
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: European Respiratory Journal (publishedVersion)
PubMed (publishedVersion)
Funders: AstraZeneca
GlaxoSmithKline
Topics: Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Asthma and respiratory diseases
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Smoking Behavior and Cessation
Keywords: chronic obstructive pulmonary disease, COPD mortality, comorbidities, cardiovascular disease, lung cancer, low-grade inflammation, respiratory failure, FEV1, BODE index, St George's Respiratory Questionnaire, mortality prediction, health assessment
MeSH terms: Health Status, Humans, Comorbidity, Pulmonary Disease, Chronic Obstructive

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