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Cited by 1,052Chronic Obstructive Pulmonary Disease (COPD) ResearchAsthma and respiratory diseasesSmoking Behavior and Cessation

The DOI matches its Crossref record; 141 of the 142 references it cites were found in a registry or an index.

Mortality in COPD: role of comorbidities

Open access
Sin, D. D., Anthonisen, N. R., Soriano, J. B., Agusti, A. G.·2006·European Respiratory Journal
DOI 10.1183/09031936.00133805
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Abstract

Chronic obstructive pulmonary disease (COPD) represents an increasing burden throughout the world. COPD-related mortality is probably underestimated because of the difficulties associated with identifying the precise cause of death. Respiratory failure is considered the major cause of death in advanced COPD. Comorbidities such as cardiovascular disease and lung cancer are also major causes and, in mild-to-moderate COPD, are the leading causes of mortality. The links between COPD and these conditions are not fully understood. However, a link through the inflammation pathway has been suggested, as persistent low-grade pulmonary and systemic inflammation, both known risk factors for cardiovascular disease and cancer, are present in COPD independent of cigarette smoking. Lung-specific measurements, such as forced expiratory volume in one second (FEV(1)), predict mortality in COPD and in the general population. However, composite tools, such as health-status measurements (e.g. St George's Respiratory Questionnaire) and the BODE index, which incorporates Body mass index, lung function (airflow Obstruction), Dyspnoea and Exercise capacity, predict mortality better than FEV(1) alone. These multidimensional tools may be more valuable because, unlike predictive approaches based on single parameters, they can reflect the range of comorbidities and the complexity of underlying mechanisms associated with COPD. The current paper reviews the role of comorbidities in chronic obstructive pulmonary disease mortality, the putative underlying pathogenic link between chronic obstructive pulmonary disease and comorbid conditions (i.e. inflammation), and the tools used to predict chronic obstructive pulmonary disease mortality.

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Show all 142 references

Research works printed but not linked: 11

  1. 1997, Monaldi Arch Chest Dis, 52, 43
  2. 1998, Monaldi Arch Chest Dis, 53, 324
  3. 1999, Eur Respir J, 14, 387s
  4. 10.1001/jama.1994.03520190043033 · DOI
  5. 2000, J Am Geriatr Soc, 48, S91
  6. European Respiratory Society, European Lung Foundation. Loddenkemper R, Gibson GJ, Sibille Y, eds. Lung Health in Europe Facts and Figures. Sheffield, ERSJ, 2003; pp. 34–43
  7. 2004, Chest, 125, 134S
  8. 1998, Int J Mol Med, 2, 715
  9. 2001, Chest, 119, 1294
  10. 1995, Oncogene, 11, 999
  11. 1978, Scand J Respir Dis, 59, 154

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Metadata

Authors
Sin, D. D., Anthonisen, N. R., Soriano, J. B., & Agusti, A. G.
Affiliations
  • St. Paul's Hospital (CA)
  • London School of Hygiene & Tropical Medicine (GB)
ORCID
Venue
European Respiratory Journal
Publisher
European Respiratory Society (ERS)
Published
2006-11-30
Volume
28
Issue
6
Pages
1245-1257
ISSN
  • 0903-1936 (ISSN-L)
  • 1399-3003
DOI
10.1183/09031936.00133805
OpenAlex
W2118228748
Cited by
1,052
References
142
Citations by year
2026: 22 · 2025: 44 · 2024: 43 · 2023: 40 · 2022: 36 · 2021: 60 · 2020: 61 · 2019: 55 · 2018: 61 · 2017: 63 · 2016: 76 · 2015: 61 · 2014: 77 · 2013: 74 · 2012: 51
FWCI
7.69
Type
journal article
Language
en
Open access
Locations
  • European Respiratory Journal (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • AstraZeneca
  • GlaxoSmithKline
Topics
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Asthma and respiratory diseases
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Smoking Behavior and Cessation
Keywords
chronic obstructive pulmonary disease, COPD mortality, comorbidities, cardiovascular disease, lung cancer, low-grade inflammation, respiratory failure, FEV1, BODE index, St George's Respiratory Questionnaire, mortality prediction, health assessment
MeSH terms
Health Status, Humans, Comorbidity, Pulmonary Disease, Chronic Obstructive

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