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Cited by 143

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Exercise ventilatory inefficiency in mild to end-stage COPD

Neder, J. Alberto, Arbex, Flavio F., Alencar, Maria Clara N., O’Donnell, Conor D.J., Cory, Julia, Webb, Kathy A., O’Donnell, Denis E.·2015·European Respiratory Journal
DOI 10.1183/09031936.00135514
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Abstract

Ventilatory inefficiency during exercise is a key pathophysiological feature of chronic obstructive pulmonary disease. Currently, it is unknown how this physiological marker relates to clinically relevant outcomes as resting ventilatory impairment progresses across disease stages. Slope and intercept of the linear region of the ventilation–carbon dioxide output relationship and the ratio between these variables, at the lowest point (nadir), were contrasted in 316 patients with Global Initiative for Chronic Obstructive Lung Disease (GOLD) stages 1–4 (forced expiratory volume in 1 s, ranging from 148% pred to 12% pred) and 69 aged- and gender-matched controls, Compared to controls, slope and intercept were higher in GOLD stages 1 and 2, leading to higher nadirs (p<0.05). Despite even larger intercepts in GOLD stages 3 and 4, slopes diminished as disease evolved (from mean±sd 35±6 in GOLD stage 1 to 24±5 in GOLD stage 3, p<0.05). As a result, there were no significant differences in nadirs among patient groups. Higher intercepts, across all stages (p<0.01), and to a lesser extent lower slopes in GOLD stages 2–4 (p<0.05), were related to greater mechanical constraints, worsening pulmonary gas exchange, higher dyspnoea scores, and poorer exercise capacity. Increases in the ventilation intercept best indicate the progression of exercise ventilatory inefficiency across the whole spectrum of chronic obstructive pulmonary disease severity.

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Research works printed but not linked: 37

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Metadata

Authors
Neder, J. A., Arbex, F. F., Alencar, M. C. N., O’Donnell, C. D. J., Cory, J., Webb, K. A., & O’Donnell, D. E.
Venue
European Respiratory Journal
Publisher
European Respiratory Society (ERS)
Published
2014-10-30
Volume
45
Issue
2
Pages
377-387
ISSN
  • 0903-1936
  • 1399-3003
DOI
10.1183/09031936.00135514
Cited by
143
References
1
Language
en

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