The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Lung exposure to nanoparticles modulates an asthmatic response in a mouse model
Open accessAbstract
The aim of this study was to investigate the modulation of an asthmatic response by titanium dioxide (TiO 2) or gold (Au) nanoparticles (NPs) in a murine model of diisocyanate-induced asthma. On days 1 and 8, BALB/c mice received 0.3% toluene diisocyanate (TDI) or the vehicle acetone–olive oil (AOO) on the dorsum of both ears (20 μL). On day 14, the mice were oropharyngeally dosed with 40 μL of a NP suspension (0.4 mg·mL−1(∼0.8 mg·kg−1) TiO 2 or Au). 1 day later (day 15), the mice received an oropharyngeal challenge with 0.01% TDI (20 μL). On day 16, airway hyperreactivity (AHR), bronchoalveolar lavage (BAL) cell and cytokine analysis, lung histology, and total serum immunoglobulin E were assessed. NP exposure in sensitised mice led to a two- (TiO 2) or three-fold (Au) increase in AHR, and a three- (TiO 2) or five-fold (Au) increase in BAL total cell counts, mainly comprising neutrophils and macrophages. The NPs taken up by BAL macrophages were identified by energy dispersive X-ray spectroscopy. Histological analysis revealed increased oedema, epithelial damage and inflammation. In conclusion, these results show that a low, intrapulmonary doses of TiO 2 or Au NPs can aggravate pulmonary inflammation and AHR in a mouse model of diisocyanate-induced asthma.
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Cites
Size-dependent toxicity of metal oxide particles—A comparison between nano- and micrometer size
Karlsson, H. L., Gustafsson, J., Cronholm, P., & Möller, L. (2009) · Toxicology Letters · doi:10.1016/j.toxlet.2009.03.014 · Cited by 949
Hussain, S., Boland, S., Baeza-Squiban, A., Hamel, R., Thomassen, L. C. J., Martens, J. A., Billon-Galland, M. A., Fleury-Feith, J., Moisan, F., Pairon, J.-C., et al. (2009) · Toxicology · doi:10.1016/j.tox.2009.04.001 · Cited by 347
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Cited by
Cancer therapy with iron oxide nanoparticles: Agents of thermal and immune therapies
Soetaert, F., Korangath, P., Serantes, D., Fiering, S., & Ivkov, R. (2020) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2020.06.025 · Cited by 406
Nanomaterials Versus Ambient Ultrafine Particles: An Opportunity to Exchange Toxicology Knowledge
Stone, V., Miller, M. R., Clift, M. J. D., Elder, A., Mills, N. L., Møller, P., Schins, R. P. F., Vogel, U., Kreyling, W. G., Alstrup Jensen, K., et al. (2017) · Environmental Health Perspectives · doi:10.1289/ehp424 · Cited by 370
Self-citationToxicity of Nano-Titanium Dioxide (TiO2-NP) Through Various Routes of Exposure: a Review
Shakeel, M., Jabeen, F., Shabbir, S., Asghar, M. S., Khan, M. S., & Chaudhry, A. S. (2016) · Biological Trace Element Research · doi:10.1007/s12011-015-0550-x · Cited by 320
Roulet, A., Armand, L., Dagouassat, M., Rogerieux, F., Simon-Deckers, A., Belade, E., Van Nhieu, J. T., Lanone, S., Pairon, J.-C., Lacroix, G., et al. (2012) · BMC Pulmonary Medicine · doi:10.1186/1471-2466-12-38 · Cited by 21
Metadata
- Authors
- Hussain, S., Vanoirbeek, J. A. J., Luyts, K., De Vooght, V., Verbeken, E., Thomassen, L. C. J., Martens, J. A., Dinsdale, D., Boland, S., Marano, F., Nemery, B., & Hoet, P. H. M.
- Venue
- European Respiratory Journal
- Publisher
- European Respiratory Society (ERS)
- Published
- 2010-06-07
- Volume
- 37
- Issue
- 2
- Pages
- 299-309
- ISSN
- 0903-1936 (ISSN-L)
- 1399-3003
- OpenAlex
- W2160700027
- Cited by
- 160
- References
- 2
- FWCI
- 12.82
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Hussain, S., Vanoirbeek, J. A. J., Luyts, K., De Vooght, V., Verbeken, E., Thomassen, L. C. J., Martens, J. A., Dinsdale, D., Boland, S., Marano, F., Nemery, B., & Hoet, P. H. M. (2011). Lung exposure to nanoparticles modulates an asthmatic response in a mouse model. European Respiratory Journal. https://doi.org/10.1183/09031936.00168509
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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