Intratracheally administered titanium dioxide or carbon black nanoparticles do not aggravate elastase-induced pulmonary emphysema in rats
Open accessAbstract
Background: Titanium dioxide (TiO 2) and carbon black (CB) nanoparticles (NPs) have biological effects that could aggravate pulmonary emphysema. The aim of this study was to evaluate whether pulmonary administration of TiO 2 or CB NPs in rats could induce and/or aggravate elastase-induced emphysema, and to investigate the underlying molecular mechanisms. Methods: On day 1, Sprague-Dawley rats were intratracheally instilled with 25 U kg−1 pancreatic porcine elastase or saline. On day 7, they received an intratracheal instillation of TiO 2 or CB (at 100 and 500 μg) dispersed in bovine serum albumin or bovine serum albumin alone. Animals were sacrificed at days 8 or 21, and bronchoalveolar lavage (BAL) cellularity, histological analysis of inflammation and emphysema, and lung mRNA expression of heme oxygenase-1 (HO-1), interleukin-1β (IL-1β), macrophage inflammatory protein-2, monocyte chemotactic protein-1, and matrix metalloprotease (MMP)-1, and -12 were measured. In addition, pulmonary MMP-12 expression was also analyzed at the protein level by immunohistochemistry. Results: TiO 2 NPs per se did not modify the parameters investigated, but CB NPs increased perivascular/peribronchial infiltration, and macrophage MMP-12 expression, without inducing emphysema. Elastase administration increased BAL cellularity, histological inflammation, HO-1, IL-1β and macrophage MMP-12 expression and induced emphysema. Exposure to TiO 2 NPs did not modify pulmonary responses to elastase, but exposure to CB NPs aggravated elastase-induced histological inflammation without aggravating emphysema. Conclusions: TiO 2 and CB NPs did not aggravate elastase-induced emphysema. However, CB NPs induced histological inflammation and MMP-12 mRNA and protein expression in macrophages.
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Metallic NPs such as Au and TiO2 have been suggested as potential nanocarriers for COPD treatment.
“Based on several investigations, metallic NPs such as Au and TiO2 have been suggested as potential nanocarriers for COPD treatment.187,188”
From Targeted therapy in chronic diseases using nanomaterial-based drug delivery vehicles (2019) · cites this paper as [187]
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- Authors
- Roulet, A., Armand, L., Dagouassat, M., Rogerieux, F., Simon-Deckers, A., Belade, E., Van Nhieu, J. T., Lanone, S., Pairon, J.-C., Lacroix, G., & Boczkowski, J.
- Affiliations
- Inserm (FR)
- Institut national de l'environnement industriel et des risques (FR)
- Corresponding author
- Boczkowski, Jorge
- ORCID
- Venue
- BMC Pulmonary Medicine
- Published
- 2012-07-31
- Volume
- 12
- Issue
- 1
- Pages
- 38-38
- ISSN
- 1471-2466 (ISSN-L)
- PMC
- PMC3499434
- OpenAlex
- W2134365651
- Cited by
- 21
- References
- 59
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 2 · 2022: 3 · 2021: 4 · 2020: 1 · 2019: 1 · 2017: 4 · 2015: 2 · 2013: 1
- FWCI
- 0.77
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- BMC Pulmonary Medicine (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- HAL (submittedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- Agence Nationale de la Recherche
- Institut National de la Santé et de la Recherche Médicale
- Agence Nationale de Sécurité Sanitaire de l’Alimentation, de l’Environnement et du Travail
- Société de Pneumologie de Langue Française
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Occupational and environmental lung diseases
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Inhalation and Respiratory Drug Delivery
- Keywords
- titanium dioxide nanoparticles, carbon black nanoparticles, emphysema, elastase-induced lung injury, intratracheal instillation, heme oxygenase-1, IL-1β, CXCL2, MCP-1, lung inflammation, nanoparticle-induced lung injury
- MeSH terms
- Animals, Intubation, Intratracheal, Male, Pancreatic Elastase, Pneumonia, Pulmonary Emphysema, Titanium, Rats, Sprague-Dawley, Bronchoalveolar Lavage, Models, Animal, Rats, Heme Oxygenase-1, Soot, Matrix Metalloproteinase 12, Interleukin-1beta, Nanoparticles
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Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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