Interpreting thresholds for a clinically significant change in health status in asthma and COPD
Open accessAbstract
Health status (or Health-Related Quality of Life) measurement is an established method for assessing the overall efficacy of treatments for asthma and chronic obstructive pulmonary disease (COPD). Such measurements can indicate the potential clinical significance of a treatment's effect. This paper is concerned with methods of estimating the threshold of clinical significance for three widely used health status questionnaires for asthma and COPD: the Asthma Quality of Life Questionnaire, Chronic Respiratory Questionnaire and St George's Respiratory Questionnaire. It discusses the methodology used to obtain such estimates and shows that the estimates appear to be fairly reliable; i.e. for a given questionnaire, similar estimates may be obtained in different studies. These empirically derived thresholds are all mean estimates with confidence intervals around them. The presence of these confidence intervals affects the way in which the thresholds may be used to draw inferences concerning the clinical relevance of clinical trial results. A new system of judging the magnitude of clinically significant results is proposed. Finally, an attempt is made to translate these thresholds into scenarios that illustrate what a clinically significant change with treatment may mean to an individual patient.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The SGRQ total score minimum clinically important difference is 4 units.
“SGRQ total score (minimum clinically important difference of 4 units).17”
From Cognitive behavioral therapy for management of dyspnea: A pilot study (2015) · cites this paper as [17]
The minimal clinically important difference accepted for the Chronic Respiratory Disease Questionnaire is 0.5 points.
“The minimal clinically important difference accepted for this instrument is 0.5 points (26).”
From Health Coaching and Chronic Obstructive Pulmonary Disease Rehospitalization: A Randomized Study (2016) · cites this paper as [26]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Jaeschke, R., Singer, J., & Guyatt, G. H. (1989) · Controlled Clinical Trials · doi:10.1016/0197-2456(89)90005-6 · Cited by 4,982 · see citing works
Jones, P. W., Quirk, F. H., Baveystock, C. M., & Littlejohns, P. (1992) · American Review of Respiratory Disease · doi:10.1164/ajrccm/145.6.1321 · Cited by 3,035 · see citing works
Self-citationBestall, J. C., Paul, E. A., Garrod, R., Garnham, R., Jones, P. W., & Wedzicha, J. A. (1999) · Thorax · doi:10.1136/thx.54.7.581 · Cited by 2,927 · see citing works
Self-citationThe St George's Respiratory Questionnaire
Jones, P., Quirk, F. H., & Baveystock, C. M. (1991) · Respiratory Medicine · doi:10.1016/s0954-6111(06)80166-6 · Cited by 2,729 · see citing works
Self-citationDetermining a minimal important change in a disease-specific quality of life questionnaire
JUNIPER, E. (1994) · Journal of Clinical Epidemiology · doi:10.1016/0895-4356(94)90036-1 · Cited by 1,824 · see citing works
A measure of quality of life for clinical trials in chronic lung disease
Guyatt, G. H., Berman, L. B., Townsend, M., Pugsley, S. O., & Chambers, L. W. (1987) · Thorax · doi:10.1136/thx.42.10.773 · Cited by 1,721 · see citing works
Juniper, E. F., Guyatt, G. H., Epstein, R. S., Ferrie, P. J., Jaeschke, R., & Hiller, T. K. (1992) · Thorax · doi:10.1136/thx.47.2.76 · Cited by 1,225 · see citing works
Redelmeier, D. A., Bayoumi, A. M., Goldstein, R. S., & Guyatt, G. H. (1997) · American journal of respiratory and critical care medicine · doi:10.1164/ajrccm.155.4.9105067 · Cited by 1,029 · see citing works
Griffiths, T., Burr, M., Campbell, I., Lewis-Jenkins, V, Mullins, J., Shiels, K., Turner-Lawlor, P., Payne, N., Newcombe, R., Lonescu, A., et al. (2000) · The Lancet · doi:10.1016/s0140-6736(99)07042-7 · Cited by 952 · see citing works
Meta-analysis of respiratory rehabilitation in chronic obstructive pulmonary disease
Lacasse, Y., Wong, E. Y. L., Guyatt, G. H., King, D., Cook, D. J., & Goldstein, R. S. (1996) · The Lancet · doi:10.1016/s0140-6736(96)04201-8 · Cited by 859 · see citing works
Health status measurement in chronic obstructive pulmonary disease
Jones, P. (2001) · Thorax · doi:10.1136/thorax.56.11.880 · Cited by 547 · see citing works
Self-citationInterpreting treatment effects in randomised trials
Guyatt, G. H., Juniper, E. F., Walter, S. D., Griffith, L. E., & Goldstein, R. S. (1998) · BMJ · doi:10.1136/bmj.316.7132.690 · Cited by 516 · see citing works
Quality of Life Changes in COPD Patients Treated With Salmeterol
Jones, P. M., & Bosh, T. K. (1997) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.155.4.9105068 · Cited by 486 · see citing works
Self-citationAssessing the minimal important difference in symptoms: A comparison of two techniques
Redelmeier, D. A., Guyatt, G. H., & Goldstein, R. S. (1996) · Journal of Clinical Epidemiology · doi:10.1016/s0895-4356(96)00206-5 · Cited by 375 · see citing works
Quality of life and hospital re-admission in patients with chronic obstructive pulmonary disease
Osman, I., Godden, D., Friend, J. A. R., LEGGE, J. S., & Douglas, J. G. (1997) · Thorax · doi:10.1136/thx.52.1.67 · Cited by 346 · see citing works
Mölken, M. R., Custers, F. L. J., van Doorslaer, E. K. A., Jansen, C. R., Heurman, L., Maesen, F. P. V., Smeets, J. J., Bommer, A., & Raaijmakers, J. A. M. (1995) · European Respiratory Journal · doi:10.1183/09031936.95.08060888 · Cited by 190 · see citing works
Jones, P. (1994) · European Respiratory Journal · doi:10.1183/09031936.94.07010055 · Cited by 125 · see citing works
Self-citationSpirometry and Dyspnea in Patients With COPD
Redelmeier, D. A., Goldstein, R. S., Min, S. T., & Hyland, R. H. (1996) · CHEST Journal · doi:10.1378/chest.109.5.1163 · Cited by 110 · see citing works
The minimal important difference: Who's to say what is important?
Wright, J. G. (1996) · Journal of Clinical Epidemiology · doi:10.1016/s0895-4356(96)00207-7 · Cited by 102 · see citing works
Kirwan, J., de Saintonge, D. M. C., Joyce, C. R. B., & Currey, H. L. F. (1983) · Annals of the Rheumatic Diseases · doi:10.1136/ard.42.6.648 · Cited by 85 · see citing works
Barley, E. A., & Jones, P. M. (1999) · European Respiratory Journal · doi:10.1034/j.1399-3003.1999.14c18.x · Cited by 40 · see citing works
Self-citationDelaisi, B., & Gérardin, M. (2003) · PubMed · Cited by 18 · see citing works
Flagged first, then by citations
Research works printed but not linked: 3
- [10]10. Jones PW, Quirk FH, Baveystock CM, Littlejohns P. A self-complete measure for chronic airflow limitation -the St George9s Respiratory Questionnaire. Am Rev Respir Dis 1992; 145: 1321-1327.
- [12]12. Jones PW, Quirk FH, Baveystock CM. The St George9s Respiratory Questionnaire. Respir Med 1991; 85: 25-31.
- [15]15. Jones PW, Lasserson D. Relationship between change in St George9s Respiratory Questionnaire score and patients9 perception of treatment efficacy after one year of therapy with nedocromil sodium. Am Rev Respir Crit Care Med 1994; 149: A211.
Cited by
Sorted by citations
Norman, G. R., Sloan, J. A., & Wyrwich, K. W. (2003) · Medical Care · doi:10.1097/01.mlr.0000062554.74615.4c · Cited by 4,700 · see citing works
Spruit, M. A., Singh, S. J., Garvey, C., ZuWallack, R., Nici, L., Rochester, C., Hill, K., Holland, A. E., Lareau, S. C., Man, W. D.-C., et al. (2013) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201309-1634st · Cited by 3,938 · see citing works
Revicki, D. A., Hays, R. D., Cella, D. F., & Sloan, J. A. (2007) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2007.03.012 · Cited by 2,384 · see citing works
A randomized trial comparing lung-volume-reduction surgery with medical therapy for severe emphysema
(2003) · New England Journal of Medicine · doi:10.1056/nejmoa030287 · Cited by 2,071 · see citing works
American Thoracic Society/European Respiratory Society statement on pulmonary rehabilitation
Nici, L., Donner, C., Wouters, E., Zuwallack, R., Ambrosino, N., Bourbeau, J., Carone, M., Celli, B., Engelen, M., Fahy, B., et al. (2006) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200508-1211st · Cited by 1,966 · see citing works
Reddel, H. K., Taylor, D. R., Bateman, E. D., Boulet, L., Boushey, H. A., Busse, W. W., Casale, T. B., Chanez, P., Enright, P., Gibson, P. G., et al. (2009) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200801-060st · Cited by 1,918 · see citing works
The Unified Parkinson's Disease Rating Scale (UPDRS): Status and recommendations
Movement Disorder Society Task Force on Rating Scales for Parkinson's Disease (2003) · Movement Disorders · doi:10.1002/mds.10473 · Cited by 1,811 · see citing works
St. George's Respiratory Questionnaire: MCID
Jones, P. (2005) · COPD Journal of Chronic Obstructive Pulmonary Disease · doi:10.1081/copd-200050513 · Cited by 856 · see citing works
Self-citationOutcomes for COPD pharmacological trials: from lung function to biomarkers
Cazzola, M., MacNee, W., Martínez, F. J., Rabe, K. F., Franciosi, L. G., Barnes, P. J., Brusasco, V., Burge, P. S., Calverley, P. M., Celli, B. R., et al. (2008) · European Respiratory Journal · doi:10.1183/09031936.00099306 · Cited by 843 · see citing works
Self-citationKöhnlein, T., Windisch, W., Köhler, D., Drabik, A., Geiseler, J. G., Hartl, S., Karg, O., Laier-Groeneveld, G., Nava, S., Schönhofer, B., et al. (2014) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(14)70153-5 · Cited by 814 · see citing works
British Thoracic Society guideline on pulmonary rehabilitation in adults: accredited by NICE
Bolton, C. E., Bevan-Smith, E. F., Blakey, J. D., Crowe, P., Elkin, S. L., Garrod, R., Greening, N. J., Heslop, K., Hull, J. H., Man, W. D.-C., et al. (2013) · Thorax · doi:10.1136/thoraxjnl-2013-203808 · Cited by 717 · see citing works
Maintenance therapy with budesonide and formoterol in chronicobstructive pulmonary disease
Calverley, P. M. A., Boonsawat, W., Cseke, Z., Zhong, N., Peterson, S., & Olsson, H. (2003) · European Respiratory Journal · doi:10.1183/09031936.03.00027003 · Cited by 727 · see citing works
Pulmonary Rehabilitation in Chronic Obstructive Pulmonary Disease
Troosters, T., Casaburi, R. H., Gosselink, R., & Decramer, M. (2005) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200408-1109so · Cited by 644 · see citing works
Mepolizumab for Eosinophilic Chronic Obstructive Pulmonary Disease
Pavord, I. D., Chanez, P., Criner, G. J., Kerstjens, H. A. M., Korn, S., Lugogo, N. L., Martinot, J., Sagara, H., Albers, F. C., Bradford, E., et al. (2017) · New England Journal of Medicine · doi:10.1056/nejmoa1708208 · Cited by 628 · see citing works
Chupp, G. L., Bradford, E., Albers, F. C., Bratton, D. J., Wang‐Jairaj, J., Nelsen, L. M., Trevor, J. L., Magnan, A., & Brinke, A. T. (2017) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(17)30125-x · Cited by 597 · see citing works
Miravitlles, M. (2004) · Thorax · doi:10.1136/thx.2003.008730 · Cited by 557 · see citing works
Inhaled corticosteroids for stable chronic obstructive pulmonary disease
Yang, I. A., Clarke, M., Sim, E., & Fong, K. M. (2012) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd002991.pub3 · Cited by 530 · see citing works
Minimal Clinically Important Differences in Pharmacological Trials
Jones, P., Beeh, K. M., Chapman, K. R., Decramer, M., Mahler, D. A., & Wedzicha, J. A. (2014) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201310-1863pp · Cited by 483 · see citing works
Self-citationImpact of preventing exacerbations on deterioration of health status in COPD
Spencer, S., Calverley, P. M. A., Burge, P. S., & Jones, P. M. (2004) · European Respiratory Journal · doi:10.1183/09031936.04.00121404 · Cited by 439 · see citing works
Self-citationAgache, I. O., Beltran, J., Akdiş, C. A., Akdiş, M., Canelo‐Aybar, C., Canonica, G. W., Casale, T. B., Chivato, T., Corren, J., Giacco, S. D., et al. (2020) · Allergy · doi:10.1111/all.14221 · Cited by 414 · see citing works
Contemporary Management of Chronic Obstructive Pulmonary Disease
Sin, D. D., McAlister, F. A., Man, S. F. P., & Anthonisen, N. R. (2003) · JAMA · doi:10.1001/jama.290.17.2301 · Cited by 400 · see citing works
Kemp, S. V., Slebos, D., Kirk, A. J. B., Kornaszewska, M., Carron, K., Ek, L., Broman, G., Hillerdal, G., Mal, H., Pison, C. M., et al. (2017) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201707-1327oc · Cited by 392 · see citing works
Maltais, F., Bourbeau, J., Shapiro, S., Lacasse, Y., Perrault, H., Baltzan, M., Hernandez, P., Rouleau, M., Julien, M., Parenteau, S., et al. (2008) · Annals of Internal Medicine · doi:10.7326/0003-4819-149-12-200812160-00006 · Cited by 378 · see citing works
Griffith, D. E., Eagle, G. L., Thomson, R. M., Aksamit, T. R., Hasegawa, N., Morimoto, K., Addrizzo-Harris, D. J., O’Donnell, A. E., Marras, T. K., Flume, P. A., et al. (2018) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201807-1318oc · Cited by 362 · see citing works
Naunheim, K. S., Wood, D. E., Mohsenifar, Z., Sternberg, A. L., Criner, G. J., DeCamp, M. M., Deschamps, C. C., Martínez, F. J., Sciurba, F. C., Tonascia, J. A., et al. (2006) · The Annals of Thoracic Surgery · doi:10.1016/j.athoracsur.2006.05.069 · Cited by 346 · see citing works
Health-related quality of life is related to COPD disease severity
Ståhl, E., Lindberg, A., Jansson, S., Rönmark, E., Svensson, K., Andersson, F., Löfdahl, C., & Lundbäck, B. (2005) · Health and Quality of Life Outcomes · doi:10.1186/1477-7525-3-56 · Cited by 340 · see citing works
Properties of the COPD assessment test in a cross-sectional European study
Jones, P., Brusselle, G., Negro, R. W. D., Ferrer, M., Kardos, P., Levy, M. L., Perez, T., Soler‐Cataluña, J. J., van der Molen, T., Adamek, L., et al. (2011) · European Respiratory Journal · doi:10.1183/09031936.00177210 · Cited by 339 · see citing works
Self-citationTime course of recovery of health status following an infective exacerbation of chronic bronchitis
Spencer, S. (2003) · Thorax · doi:10.1136/thorax.58.7.589 · Cited by 330 · see citing works
Kardos, P., Wencker, M., Glaab, T., & Vogelmeier, C. F. (2006) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200602-244oc · Cited by 313 · see citing works
Australian and N ew Z ealand P ulmonary R ehabilitation G uidelines
Alison, J. A., McKeough, Z. J., Johnston, K., McNamara, R. J., Spencer, L. M., JENKINS, S. C., Hill, C. J., McDonald, V. M., Frith, P. A., Cafarella, P., et al. (2017) · Respirology · doi:10.1111/resp.13025 · Cited by 312 · see citing works
The association between childhood asthma and adult chronic obstructive pulmonary disease
Tai, A., Tran, H., Roberts, M. F., Clarke, N., Wilson, J. W., & ROBERTSON, C. F. (2014) · Thorax · doi:10.1136/thoraxjnl-2013-204815 · Cited by 305 · see citing works
Minimum clinically important improvement for the incremental shuttle walking test
Singh, S., Jones, P. M., Evans, R. A., & Morgan, M. (2008) · Thorax · doi:10.1136/thx.2007.081208 · Cited by 300 · see citing works
Self-citationJones, P., Tabberer, M., & Chen, W.-H. (2011) · BMC Pulmonary Medicine · doi:10.1186/1471-2466-11-42 · Cited by 281 · see citing works
Self-citationEAACI Biologicals Guidelines—Recommendations for severe asthma
Agache, I. O., Akdiş, C. A., Akdiş, M., Canonica, G. W., Casale, T. B., Chivato, T., Corren, J., Chu, D. K., Giacco, S. D., Eiwegger, T., et al. (2020) · Allergy · doi:10.1111/all.14425 · Cited by 280 · see citing works
Nannini, L. J., Poole, P., Milan, S. J., Holmes, R. S., & Normansell, R. (2013) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003794.pub4 · Cited by 274 · see citing works
Inhaled Colistin in Patients with Bronchiectasis and Chronic Pseudomonas aeruginosa Infection
HAWORTH, C. S., Foweraker, J. E., Wilkinson, P., Kenyon, R. F., & Bilton, D. (2014) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201312-2208oc · Cited by 263 · see citing works
Puhan, M. A., Scharplatz, M., Troosters, T., & Steurer, J. (2005) · Respiratory Research · doi:10.1186/1465-9921-6-54 · Cited by 249 · see citing works
Outcomes and markers in the assessment of chronic obstructive pulmonary disease
Jones, P., & Agustí, A. G. N. (2006) · European Respiratory Journal · doi:10.1183/09031936.06.00145104 · Cited by 242 · see citing works
Self-citationEffect of Endobronchial Coils vs Usual Care on Exercise Tolerance in Patients With Severe Emphysema
Sciurba, F. C., Criner, G. J., Strange, C., Shah, P. L., Michaud, G. C., Connolly, T. A., Deslée, G., Tillis, W. P., Delage, A., Marquette, C., et al. (2016) · JAMA · doi:10.1001/jama.2016.6261 · Cited by 244 · see citing works
Health-related quality of life in patients by COPD severity within primary care in Europe
Jones, P., Brusselle, G., Negro, R. W. D., Ferrer, M., Kardos, P., Levy, M. L., Perez, T., Soler‐Cataluña, J. J., van der Molen, T., Adamek, L., et al. (2010) · Respiratory Medicine · doi:10.1016/j.rmed.2010.09.004 · Cited by 241 · see citing works
Self-citationDifferential response to pulmonary rehabilitation in COPD: multidimensional profiling
Spruit, M. A., Augustin, I. M. L., Vanfleteren, L. E. G. W., Janssen, D. J. A., Gaffron, S., Pennings, H.-J., Smeenk, F. W. J. M., Pieters, W. R., van den Bergh, J. J. A. M., Michels, A.-J., et al. (2015) · European Respiratory Journal · doi:10.1183/13993003.00350-2015 · Cited by 239 · see citing works
The 6-Min Walk Distance, Peak Oxygen Uptake, and Mortality in COPD
Côté, C., Pinto-Plata, V., Kasprzyk, K., Dordelly, L. J., & Celli, B. R. (2007) · CHEST Journal · doi:10.1378/chest.07-2050 · Cited by 238 · see citing works
Minimal important difference of the transition dyspnoea index in a multinational clinical trial
Witek, T. J., & Mahler, D. A. (2003) · European Respiratory Journal · doi:10.1183/09031936.03.00068503a · Cited by 225 · see citing works
Kocks, J., Tuinenga, M. G., Uil, S. M., van den Berg, J., Ståhl, E., & van der Molen, T. (2006) · Respiratory Research · doi:10.1186/1465-9921-7-62 · Cited by 222 · see citing works
Proactive integrated care improves quality of life in patients with COPD
Koff, P. B., Jones, R. H., Cashman, J., Voelkel, N. F., & Vandivier, R. W. (2009) · European Respiratory Journal · doi:10.1183/09031936.00063108 · Cited by 220 · see citing works
Functional Status and Quality of Life in Chronic Obstructive Pulmonary Disease
Reardon, J. Z., Lareau, S. C., & ZuWallack, R. (2006) · The American Journal of Medicine · doi:10.1016/j.amjmed.2006.08.005 · Cited by 216 · see citing works
The Role of Long-Acting Bronchodilators in the Management of Stable COPD
Tashkin, D. P., & Cooper, C. B. (2004) · CHEST Journal · doi:10.1378/chest.125.1.249 · Cited by 208 · see citing works
Jones, P., Adamek, L., Nadeau, G. A., & Banik, N. (2012) · European Respiratory Journal · doi:10.1183/09031936.00125612 · Cited by 210 · see citing works
Self-citationClinical Cough IV:What is the Minimal Important Difference for the Leicester Cough Questionnaire?
Raj, A. A., Pavord, D. I., & Birring, S. S. (2009) · Handbook of experimental pharmacology · doi:10.1007/978-3-540-79842-2_16 · Cited by 202 · see citing works
Phase II study of a neutrophil elastase inhibitor (AZD9668) in patients with bronchiectasis
Stockley, R. A., Soyza, A. D., Gunawardena, K. A., Perrett, J., Forsman‐Semb, K., Entwistle, N., & Snell, N. J. C. (2013) · Respiratory Medicine · doi:10.1016/j.rmed.2012.12.009 · Cited by 202 · see citing works
The Effects of Pulmonary Rehabilitation in the National Emphysema Treatment Trial
Ries, A. L., Make, B. J., Lee, S. M., Krasna, M. J., Bartels, M. N., Crouch, R. H., & Fishman, A. P. (2005) · CHEST Journal · doi:10.1378/chest.128.6.3799 · Cited by 199 · see citing works
Seemungal, T. (2009) · International Journal of Chronic Obstructive Pulmonary Disease · doi:10.2147/copd.s3385 · Cited by 197 · see citing works
Cook, J., Hislop, J., Adewuyi, T., Harrild, K., Altman, D., Ramsay, C., Fraser, C., Buckley, B., Fayers, P., Harvey, I., et al. (2014) · Health Technology Assessment · doi:10.3310/hta18280 · Cited by 194 · see citing works
Ryrsø, C. K., Godtfredsen, N. S., Kofod, L. M., Lavesen, M., Mogensen, L., Tobberup, R., Farver-Vestergaard, I., Edemann-Callesen, H., Tendal, B., Lange, P., et al. (2018) · BMC Pulmonary Medicine · doi:10.1186/s12890-018-0718-1 · Cited by 184 · see citing works
Herth, F. J. F., Valipour, A., Shah, P. L., Eberhardt, R., Grah, C., Egan, J. J., Ficker, J. H., Wagner, M., Witt, C. C., Liebers, U., et al. (2016) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(16)00045-x · Cited by 178 · see citing works
Schünemann, H. J. (2003) · Journal of Clinical Epidemiology · doi:10.1016/s0895-4356(03)00115-x · Cited by 175 · see citing works
Health Coaching and Chronic Obstructive Pulmonary Disease Rehospitalization: A Randomized Study
Benzo, R., Vickers, K., Novotny, P. J., Tucker, S., Hoult, J., Neuenfeldt, P., Connett, J., Lorig, K., & McEvoy, C. (2016) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201512-2503oc · Cited by 176 · see citing works
Monninkhof, E. M., van der Valk, P., van der Palen, J. A. M., van Herwaarden, C., & Zielhuis, G. G. (2003) · European Respiratory Journal · doi:10.1183/09031936.03.00047003 · Cited by 176 · see citing works
Tiotropium + olodaterol shows clinically meaningful improvements in quality of life
Singh, D., Ferguson, G. T., Bolitschek, J., Grönke, L., Hallmann, C., Bennett, N. L., Abrahams, R., Schmidt, O., & Bjermer, L. H. (2015) · Respiratory Medicine · doi:10.1016/j.rmed.2015.08.002 · Cited by 175 · see citing works
The correlation between asthma control and health status: the GOAL study
Bateman, E. D., Bousquet, J., Keech, M. L., Busse, W. W., Clark, T. J. H., & Pedersen, S. (2006) · European Respiratory Journal · doi:10.1183/09031936.00128505 · Cited by 173 · see citing works
A multicenter trial of an intrabronchial valve for treatment of severe emphysema
Wood, D. E., McKenna, R. J., Yusen, R. D., Sterman, D. H., Ost, D. E., Springmeyer, S. C., Gonzalez, H. X., Mulligan, M. S., Gildea, T. R., Houck, W. V., et al. (2006) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2006.06.051 · Cited by 172 · see citing works
Tsiligianni, I., van der Molen, T., Moraitaki, D., López, I. A., Kocks, J. W. H., Karagiannis, K., Siafakas, N. M., & Tzanakis, Ν. (2012) · BMC Pulmonary Medicine · doi:10.1186/1471-2466-12-20 · Cited by 168 · see citing works
Greer, J. A., Jacobs, J. M., El-Jawahri, A. R., Nipp, R. D., Gallagher, E. R., Pirl, W. F., Park, E. R., Muzikansky, A., Jacobsen, J. C., Jackson, V. A., et al. (2017) · Journal of Clinical Oncology · doi:10.1200/jco.2017.73.7221 · Cited by 170 · see citing works
The clinical utility of long-term humidification therapy in chronic airway disease
Rea, H. H., McAuley, S., Jayaram, L., Garrett, J., Hockey, H., Storey, L., O'Donnell, G., Haru, L., Payton, M. J., & O'Donnell, K. (2010) · Respiratory Medicine · doi:10.1016/j.rmed.2009.12.016 · Cited by 166 · see citing works
The clinical benefit of mepolizumab replacing omalizumab in uncontrolled severe eosinophilic asthma
Chapman, K. R., Albers, F. C., Chipps, B. E., Muñoz, X., Devouassoux, G., Bergna, M. A., Galkin, D., Azmi, J., Mouneimne, D., Price, R. G., et al. (2019) · Allergy · doi:10.1111/all.13850 · Cited by 162 · see citing works
Stickland, M. K., Jourdain, T., Wong, E. Y. L., Rodgers, W. M., Jendzjowsky, N. G., & MacDonald, G. F. (2011) · Canadian Respiratory Journal · doi:10.1155/2011/640865 · Cited by 161 · see citing works
Obesity and COPD: Associated Symptoms, Health-related Quality of Life, and Medication Use
Cecere, L. M., Littman, A. J., Slatore, C. G., Udris, E. M., Bryson, C. L., Boyko, E. J., Pierson, D. J., & Au, D. H. (2011) · COPD Journal of Chronic Obstructive Pulmonary Disease · doi:10.3109/15412555.2011.586660 · Cited by 160 · see citing works
Inhaled corticosteroids for stable chronic obstructive pulmonary disease
Yang, I. A., Fong, K. M., Sim, E., Black, P., & Lasserson, T. J. (2007) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd002991.pub2 · Cited by 153 · see citing works
Twice-Yearly Depemokimab in Severe Asthma with an Eosinophilic Phenotype
Jackson, D. J., Wechsler, M. E., Jackson, D. J., Bernstein, D., Korn, S., Pfeffer, P., Chen, R., Saito, J., Martinez, G. D. L., Dymek, L., et al. (2024) · New England Journal of Medicine · doi:10.1056/nejmoa2406673 · Cited by 150 · see citing works
The assessment of health status among patients with COPD
Curtis, J. R., & Patrick, D. L. (2003) · European Respiratory Journal · doi:10.1183/09031936.03.00078102 · Cited by 145 · see citing works
Pulmonary rehabilitation and COPD: providing patients a good environment for optimizing therapy
Corhay, J. L., Nguyen, D., Cauwenberge, H. V., & Louis, R. E. (2013) · International Journal of COPD · doi:10.2147/copd.s52012 · Cited by 144 · see citing works
Clinical pharmacy‐led disease and medicine management programme for patients with COPD
Khdour, M. R., Kidney, J. C., Smyth, B. M., & McElnay, J. C. (2009) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.2009.03493.x · Cited by 144 · see citing works
Agache, I. O., Rocha, C. A., Beltran, J., Song, Y., Posso, M., Solà, I., Alonso‐Coello, P., Akdiş, C. A., Akdiş, M., Canonica, G. W., et al. (2020) · Allergy · doi:10.1111/all.14235 · Cited by 142 · see citing works
Yamaguti, W. P. S., Barbosa, R. C. C., Neto, A. P., Chammas, M. C., Gomes, A. C., Salge, J. M., Moriya, H. T., Cukier, A., & Carvalho, C. R. F. (2012) · Archives of Physical Medicine and Rehabilitation · doi:10.1016/j.apmr.2011.11.026 · Cited by 140 · see citing works
Blinded 12-week comparison of once-daily indacaterol and tiotropium in COPD
Buhl, R., Dunn, L., Disdier, C., Lassen, C., Amos, C., Henley, M., & Krämer, B. (2011) · European Respiratory Journal · doi:10.1183/09031936.00191810 · Cited by 139 · see citing works
A Multicenter Pilot Study of a Bronchial Valve for the Treatment of Severe Emphysema
Sterman, D. H., Mehta, A. C., Wood, D. E., Mathur, P. N., McKenna, R., Ost, D. E., Truwit, J. D., Diaz, P., Wahidi, M. M., Cerfolio, R. J., et al. (2009) · Respiration · doi:10.1159/000259318 · Cited by 132 · see citing works
Negative impacts of unreported COPD exacerbations on health-related quality of life at 1 year
Xu, W., Collet, J., Shapiro, S., Lin, Y., Yang, T., Wang, C., & Bourbeau, J. (2009) · European Respiratory Journal · doi:10.1183/09031936.00079409 · Cited by 132 · see citing works
How much change in pain score does really matter to patients?
Bahreini, M., Safaie, A., Mirfazaelian, H., & Jalili, M. (2019) · The American Journal of Emergency Medicine · doi:10.1016/j.ajem.2019.158489 · Cited by 132 · see citing works
Outcome measures in chronic obstructive pulmonary disease (COPD): strengths and limitations
Glaab, T., Vogelmeier, C., & Buhl, R. (2010) · Respiratory Research · doi:10.1186/1465-9921-11-79 · Cited by 130 · see citing works
Oostenbrink, J. B., Mölken, M. R., Al, M., van Noord, J. A., & Vincken, W. (2004) · European Respiratory Journal · doi:10.1183/09031936.03.00083703 · Cited by 129 · see citing works
Maltais, F., Bjermer, L. H., Kerwin, E., Jones, P., Watkins, M. L., Tombs, L., Naya, I. P., Boucot, I. H., Lipson, D. A., Compton, C. H., et al. (2019) · Respiratory Research · doi:10.1186/s12931-019-1193-9 · Cited by 128 · see citing works
Self-citationDietary counselling and food fortification in stable COPD: a randomised trial
Weekes, C. E., Emery, P. W., & Elia, M. (2008) · Thorax · doi:10.1136/thx.2008.097352 · Cited by 127 · see citing works
Multicentre European study for the treatment of advanced emphysema with bronchial valves
Ninane, V., Geltner, C., Bezzi, M., Foccoli, P., Gottlieb, J., Welte, T., Seijo, L. M., Zulueta, J. J., Munavvar, M., Rosell, A., et al. (2012) · European Respiratory Journal · doi:10.1183/09031936.00019711 · Cited by 125 · see citing works
Self-citationLongitudinal deteriorations in patient reported outcomes in patients with COPD
Oga, T., Nishimura, K., Tsukino, M., Satô, S., Hajiro, T., & Mishima, M. (2006) · Respiratory Medicine · doi:10.1016/j.rmed.2006.04.001 · Cited by 125 · see citing works
Long-term benefits of airway clearance in bronchiectasis: a randomised placebo-controlled trial
Muñoz, G., de Gracia, J., Buxó, M., Fernández, A. Á., & Vendrell, M. (2018) · European Respiratory Journal · doi:10.1183/13993003.01926-2017 · Cited by 125 · see citing works
Moore, W. C., Kornmann, O., Humbert, M. J. C., Poirier, C., Bel, E. H., Kaneko, N., Smith, S. G., Martin, N., Gilson, M. J., Price, R. G., et al. (2021) · European Respiratory Journal · doi:10.1183/13993003.00396-2021 · Cited by 124 · see citing works
Aboumatar, H., Naqibuddin, M., Chung, S., Chaudhry, H., Kim, S. W., Saunders, J., Lee, B.-N. R., Gurses, A., Knowlton, A., Pronovost, P., et al. (2019) · Journal of the American Medical Association (JAMA) · doi:10.1001/jama.2019.11982 · Cited by 110 · see citing works
Impact of frequency of COPD exacerbations on pulmonary function, health status and clinical outcomes
Kesten, S. (2009) · International Journal of COPD · doi:10.2147/copd.s4862 · Cited by 122 · see citing works
Mahler, D. A., Kerwin, E., Ayers, T. S., FowlerTaylor, A., Maitra, S., Thach, C. T., Lloyd, M. L., Patalano, F., & Banerji, D. D. (2015) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201505-1048oc · Cited by 119 · see citing works
Lou, P., Zhu, Y., Chen, P., Zhang, P., Yu, J., Zhang, N., Chen, N., Zhang, L., Wu, H., & Zhao, J. (2012) · BMC Pulmonary Medicine · doi:10.1186/1471-2466-12-53 · Cited by 119 · see citing works
Wacker, M. E., Jörres, R. A., Karch, A., Wilke, S., Heinrich, J., Karrasch, S., Koch, A., Schulz, H., Watz, H., Leidl, R., et al. (2016) · BMC Pulmonary Medicine · doi:10.1186/s12890-016-0238-9 · Cited by 118 · see citing works
Pulmonary rehabilitation in lung transplant candidates
Li, M. M., Mathur, S., Chowdhury, N., Helm, D., & Singer, L. G. (2013) · The Journal of Heart and Lung Transplantation · doi:10.1016/j.healun.2013.04.002 · Cited by 116 · see citing works
Doll, H., & Miravitlles, M. (2005) · PharmacoEconomics · doi:10.2165/00019053-200523040-00005 · Cited by 116 · see citing works
Golmohammadi, K., Jacobs, P., & Sin, D. (2004) · Lung · doi:10.1007/s00408-004-3110-2 · Cited by 114 · see citing works
Hansel, N. N., Putcha, N., Woo, H., Peng, R. D., Diette, G. B., Fawzy, A., Wise, R. A., Romero, K. M., Davis, M. F., Rule, A. M., et al. (2021) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.202103-0604oc · Cited by 114 · see citing works
Effects of COPD self-care management education at a nurse-led primary health care clinic
Efraimsson, E. Ö., Hillervik, C., & Ehrenberg, A. (2008) · Scandinavian Journal of Caring Sciences · doi:10.1111/j.1471-6712.2007.00510.x · Cited by 112 · see citing works
Coventry, P. A., Gemmell, I., & Todd, C. J. (2011) · BMC Pulmonary Medicine · doi:10.1186/1471-2466-11-49 · Cited by 109 · see citing works
Interpreting and Reporting Results Based on Patient-Reported Outcomes
Revicki, D. A., Erickson, P., Sloan, J. A., Dueck, A. C., Guess, H. A., & Santanello, N. C. (2007) · Value in Health · doi:10.1111/j.1524-4733.2007.00274.x · Cited by 104 · see citing works
Nannini, L. J., Poole, P., Milan, S. J., & Kesterton, A. (2013) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd006826.pub2 · Cited by 103 · see citing works
- Authors
- Jones, P. W.
- Affiliations
- St George's, University of London (GB)
- Corresponding author
- Jones, P.W.
- ORCID
- Jones, P.W.
- Venue
- European Respiratory Journal
- Publisher
- European Respiratory Society (ERS)
- Published
- 2002-03
- Volume
- 19
- Issue
- 3
- Pages
- 398-404
- ISSN
- 0903-1936 (ISSN-L)
- 1399-3003
- OpenAlex
- W2141887601
- Cited by
- 585
- References
- 22
- Citations by year
- 2026: 12 · 2025: 8 · 2024: 5 · 2023: 11 · 2022: 17 · 2021: 26 · 2020: 40 · 2019: 30 · 2018: 21 · 2017: 33 · 2016: 22 · 2015: 32 · 2014: 40 · 2013: 37 · 2012: 22
- FWCI
- 22.66
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- European Respiratory Journal (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
- Social Sciences › Economics, Econometrics and Finance › Economics and Econometrics › Health Systems, Economic Evaluations, Quality of Life
- Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
- Keywords
- clinically significant change, health-related quality of life, asthma, chronic obstructive pulmonary disease, Asthma Quality of Life Questionnaire, Chronic Respiratory Questionnaire, St George's Respiratory Questionnaire, confidence intervals
- MeSH terms
- Asthma, Female, Health Status, Health Status Indicators, Humans, Male, Prognosis, Quality of Life, Surveys and Questionnaires, Respiratory Function Tests, Sensitivity and Specificity, Severity of Illness Index, Reproducibility of Results, Confidence Intervals, Treatment Outcome, Patient Satisfaction, Pulmonary Disease, Chronic Obstructive
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
