The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
Neutrophil degranulation and cell lysis is associated with clinical severity in virus-induced asthma
Open accessAbstract
Acute exacerbations of asthma are frequently caused by viral infections, but the inflammatory mechanisms in virus-induced asthma are poorly understood. The aim of the present study was to determine whether viral infection in acute asthma was associated with increased sputum neutrophil degranulation and increased cellular lysis and whether these changes are related to clinical severity. Adults (n=49) presenting to the emergency department with acute asthma were examined for infection by means of sputum direct-fluorescence antigen detection, sputum culture, and sputum polymerase chain reaction for Mycoplasma, Chlamydia and Legionella pneumophila, and all common respiratory viruses. Subjects infected with one of these agents were classed as having an infective exacerbation. Spirometry and sputum induction were performed on presentation and 4–5 weeks later. Thirty-seven subjects (76%) had virus infection and acute asthma. Those with virus infection had increased sputum neutrophils (p<0.05) and increased neutrophil elastase (p<0.05), this was related to increased elevated sputum lactate dehydrogenase (LDH). Subjects with noninfective asthma had an increase in the proportion of sputum eosinophils. Both groups had elevated sputum eosinophil cationic protein (ECP) concentrations. Higher levels of sputum LDH and ECP were associated with a longer hospital stay. Virus infection and acute asthma is associated with neutrophilic inflammation, cell lysis and more severe clinical disease.
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Cites
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Self-citationRespiratory Syncytial Virus and Parainfluenza Virus
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Prominent neutrophilic inflammation in sputum from subjects with asthma exacerbation
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Rhinoviruses infect the lower airways
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Self-citationUsefulness of lactate dehydrogenase and its isoenzymes as indicators of lung damage or inflammation
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Self-citationGIBSON, P. G., WLODARCZYK, J. W., HENSLEY, M. J., GLEESON, M., HENRY, R. L., CRIPPS, A. W., & CLANCY, R. L. (1998) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.158.1.9705031 · Cited by 232
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Cited by
Asthma: defining of the persistent adult phenotypes
Wenzel, S. E. (2006) · The Lancet · doi:10.1016/s0140-6736(06)69290-8 · Cited by 1,043
Air Pollution and Respiratory Viral Infection
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Acute exacerbations of asthma: epidemiology, biology and the exacerbation‐prone phenotype
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The role of viruses in acute exacerbations of asthma
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Self-citationHost DNA released by NETosis promotes rhinovirus-induced type-2 allergic asthma exacerbation
Toussaint, M., Jackson, D. J., Swieboda, D., Guedán, A., Tsourouktsoglou, T.-D., Ching, Y. M., Radermecker, C., Makrinioti, H., Aniscenko, J., Bartlett, N. W., et al. (2017) · Nature Medicine · doi:10.1038/nm.4332 · Cited by 319
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Metadata
- Authors
- Wark, P. A. B., Johnston, S. L., Moric, I., Simpson, J. L., Hensley, M. J., & Gibson, P. G.
- Venue
- European Respiratory Journal
- Publisher
- European Respiratory Society (ERS)
- Published
- 2001-01-01
- Volume
- 19
- Issue
- 1
- Pages
- 68-75
- ISSN
- 0903-1936 (ISSN-L)
- 1399-3003
- OpenAlex
- W2155398035
- Cited by
- 373
- References
- 23
- FWCI
- 4.05
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Wark, P. A. B., Johnston, S. L., Moric, I., Simpson, J. L., Hensley, M. J., & Gibson, P. G. (2002). Neutrophil degranulation and cell lysis is associated with clinical severity in virus-induced asthma. European Respiratory Journal. https://doi.org/10.1183/09031936.02.00226302
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