Cited by 352Asthma and respiratory diseasesOccupational exposure and asthmaRespiratory viral infections research

The role of viruses in acute exacerbations of asthma

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Jackson, David J., Johnston, Sebastian L.·2010·Journal of Allergy and Clinical Immunology

Abstract

Viral respiratory infections are the most common cause of an acute asthma exacerbation in both children and adults and represent a significant global health burden. An increasing body of evidence supports the hypothesis that these infections cause a greater degree of morbidity in asthmatic subjects than in the healthy population, emphasizing a discrepancy in the antiviral response of asthmatics. In this review we discuss why such a discrepancy might exist, examining the role of the bronchial epithelium as well as the main inflammatory cells, mediators, and molecular pathways that are involved in the immune response. In addition, the potential impact of virus-induced asthma exacerbations on airway remodelling is reviewed and we explore which therapeutic options might be of benefit in preventing the deterioration of asthma control seen following viral infection.

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Crossref · 10.1016/j.jaci.2010.04.021

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  • Impaired innate anti-viral immunity with diminished interferon induction to rhinovirus has been reported in both children and adults with severe asthma.

    “Impaired innate anti-viral immunity with diminished interferon induction to rhinovirus has been reported in both children and adults with severe asthma (77–79).”

    From Epidemiology of Asthma in Children and Adults (2019) · cites this paper as [77]

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Research works printed but not linked: 6

  1. [58]Kurt-Jones E.A. Popova L. Kwinn L. Haynes L.M. Jones L.P. Tripp R.A. Pattern recognition receptors TLR4 and CD14 mediate response to RSV Nat Immunol 1 2000 398 401 11062499
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  6. [124]Volonaki E. Psarras S. Xepapadaki P. Psomali D. Gourgiotis D. Papadopoulos N.G. Synergistic effects of fluticasone propionate and salmeterol on inhibiting rhinovirus-induced epithelial production of remodelling-associated growth factors Clin Exp Allergy 36 2006 1268 1273 17014435

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Authors
Jackson, D. J., & Johnston, S. L.
Affiliations
Imperial College London (GB)
Corresponding author
Jackson, David J.
Venue
Journal of Allergy and Clinical Immunology
Publisher
Elsevier BV
Published
2010-06
Volume
125
Issue
6
Pages
1178-1187
ISSN
0091-6749 (ISSN-L)
OpenAlex
W1966647482
Cited by
351
References
130
Citations by year
2026: 9 · 2025: 7 · 2024: 10 · 2023: 15 · 2022: 21 · 2021: 26 · 2020: 24 · 2019: 18 · 2018: 19 · 2017: 24 · 2016: 26 · 2015: 26 · 2014: 35 · 2013: 33 · 2012: 24
FWCI
2.92
Type
journal article
Language
en
Open access
Locations
  • Journal of Allergy and Clinical Immunology (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
American Academy of Allergy Asthma and Immunology
Topics
  • Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Occupational exposure and asthma
  • Health Sciences › Medicine › Epidemiology › Respiratory viral infections research
Keywords
asthma exacerbations, respiratory viral infections, antiviral immunity, bronchial epithelium, airway inflammation, airway remodeling, asthma control, asthma treatment
MeSH terms
Adrenal Cortex Hormones, Adrenergic beta-Agonists, Adult, Asthma, Child, Humans, Immunity, Picornaviridae Infections, Respiratory Tract Infections, Rhinovirus, Signal Transduction, NF-kappa B, Inflammation Mediators, Respiratory Mucosa, Airway Remodeling

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