The role of viruses in acute exacerbations of asthma
Open accessAbstract
Viral respiratory infections are the most common cause of an acute asthma exacerbation in both children and adults and represent a significant global health burden. An increasing body of evidence supports the hypothesis that these infections cause a greater degree of morbidity in asthmatic subjects than in the healthy population, emphasizing a discrepancy in the antiviral response of asthmatics. In this review we discuss why such a discrepancy might exist, examining the role of the bronchial epithelium as well as the main inflammatory cells, mediators, and molecular pathways that are involved in the immune response. In addition, the potential impact of virus-induced asthma exacerbations on airway remodelling is reviewed and we explore which therapeutic options might be of benefit in preventing the deterioration of asthma control seen following viral infection.
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Impaired innate anti-viral immunity with diminished interferon induction to rhinovirus has been reported in both children and adults with severe asthma.
“Impaired innate anti-viral immunity with diminished interferon induction to rhinovirus has been reported in both children and adults with severe asthma (77–79).”
From Epidemiology of Asthma in Children and Adults (2019) · cites this paper as [77]
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Self-citation
- Authors
- Jackson, D. J., & Johnston, S. L.
- Affiliations
- Imperial College London (GB)
- Corresponding author
- Jackson, David J.
- Venue
- Journal of Allergy and Clinical Immunology
- Publisher
- Elsevier BV
- Published
- 2010-06
- Volume
- 125
- Issue
- 6
- Pages
- 1178-1187
- ISSN
- 0091-6749 (ISSN-L)
- PMC
- PMC7172767
- OpenAlex
- W1966647482
- Cited by
- 351
- References
- 130
- Citations by year
- 2026: 9 · 2025: 7 · 2024: 10 · 2023: 15 · 2022: 21 · 2021: 26 · 2020: 24 · 2019: 18 · 2018: 19 · 2017: 24 · 2016: 26 · 2015: 26 · 2014: 35 · 2013: 33 · 2012: 24
- FWCI
- 2.92
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Allergy and Clinical Immunology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- American Academy of Allergy Asthma and Immunology
- Topics
- Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Occupational exposure and asthma
- Health Sciences › Medicine › Epidemiology › Respiratory viral infections research
- Keywords
- asthma exacerbations, respiratory viral infections, antiviral immunity, bronchial epithelium, airway inflammation, airway remodeling, asthma control, asthma treatment
- MeSH terms
- Adrenal Cortex Hormones, Adrenergic beta-Agonists, Adult, Asthma, Child, Humans, Immunity, Picornaviridae Infections, Respiratory Tract Infections, Rhinovirus, Signal Transduction, NF-kappa B, Inflammation Mediators, Respiratory Mucosa, Airway Remodeling
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