The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Usefulness of lactate dehydrogenase and its isoenzymes as indicators of lung damage or inflammation
Open accessAbstract
This review describes the usefulness of monitoring the activity level of lactate dehydrogenase (LDH) and its isoenzyme pattern as indicators of pathological conditions in the lungs, such as cell damage or inflammation. Cytoplasmatic cellular enzymes, like LDH, in the extracellular space, although of no further metabolic function in this space, are still of benefit because they serve as indicators suggestive of disturbances of the cellular integrity induced by pathological conditions. Since LDH is an enzyme present in essentially all major organ systems, serum LDH activity is abnormal in a large number of disorders. Although the increase in total serum LDH activity is rather nonspecific, it is proposed that measurement of LDH activity levels and its isoenzyme pattern in pleural effusion and, more recently, in bronchoalveolar lavage fluid may provide additional information about lung and pulmonary endothelial cell injury.
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Cites
Tietz Textbook of Clinical Chemistry
(1999) · Archives of Pathology and Laboratory Medicine · doi:10.5858/123.7.646b · Cited by 2,495
Pleural Effusions: The Diagnostic Separation of Transudates and Exudates
LIGHT, R. W., MACGREGOR, M. I., LUCHSINGER, P. C., & BALL, W. C. (1972) · Annals of Internal Medicine · doi:10.7326/0003-4819-77-4-507 · Cited by 1,780
(1975) · The Enzymes · doi:10.1016/s1874-6047(08)60212-7 · Cited by 1,247
(2012) · Sarcoidosis · doi:10.1201/b13322-18 · Cited by 828
Carré, P. C., Mortenson, R. L., King, T. E., Noble, P. W., Sable, C. L., & Riches, D. W. (1991) · Journal of Clinical Investigation · doi:10.1172/jci115501 · Cited by 253
Use of bronchoalveolar lavage to detect lung damage.
Henderson, R. F. (1984) · Environmental Health Perspectives · doi:10.1289/ehp.8456115 · Cited by 184
Self-citationNeutrophilic Alveolitis in Idiopathic Pulmonary Fibrosis: The Role of Interleukin-8
Lynch, J. P., Standiford, T. J., Rolfe, M. W., Kunkel, S. L., & Strieter, R. M. (1992) · American Review of Respiratory Disease · doi:10.1164/ajrccm/145.6.1433 · Cited by 179
Henderson, R. D., Driscoll, K. E., Harkema, J. R., Lindenschmidt, R. C., Chang, I. Y., Maples, K. R., & Barr, E. B. (1995) · Fundamental and Applied Toxicology · doi:10.1006/faat.1995.1022 · Cited by 138
Self-citationHenderson, R. F., Rebar, A. H., Pickrell, J., & Newton, G. J. (1979) · Toxicology and Applied Pharmacology · doi:10.1016/0041-008x(79)90500-3 · Cited by 129
Self-citationQuist, J., & Hill, A. R. (1995) · CHEST Journal · doi:10.1378/chest.108.2.415 · Cited by 126
Cited by
Clinical Characteristics of Refractory Coronavirus Disease 2019 in Wuhan, China
Mo, P., Xing, Y., Xiao, Y., Deng, L., Zhao, Q., Wang, H., Xiong, Y., Cheng, Z., Gao, S., Liang, K., et al. (2021) · Clinical Infectious Diseases · doi:10.1093/cid/ciaa270 · Cited by 853
Kottmann, R. M., Kulkarni, A. A., Smolnycki, K. A., Lyda, E., Dahanayake, T., Salibi, R., Honnons, S., Jones, C., Isern, N. G., Hu, J. Z., et al. (2012) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201201-0084oc · Cited by 415
Neutrophil degranulation and cell lysis is associated with clinical severity in virus-induced asthma
Wark, P. A. B., Johnston, S. L., Moric, I., Simpson, J. L., Hensley, M. J., & Gibson, P. G. (2002) · European Respiratory Journal · doi:10.1183/09031936.02.00226302 · Cited by 373
Evaluating potential biomarkers of health and performance in veal calves
Marcato, F., van den Brand, H., Kemp, B., & van Reenen, K. (2018) · Frontiers in Veterinary Science · doi:10.3389/fvets.2018.00133 · Cited by 76
Cobben, N. A. M. (1999) · Experimental Lung Research · doi:10.1080/019021499270321 · Cited by 39
Self-citation
Metadata
- Authors
- Drent, M., Cobben, N., Henderson, R., Wouters, E., & van Dieijen-Visser, M.
- Venue
- European Respiratory Journal
- Publisher
- European Respiratory Society (ERS)
- Published
- 1996-08-01
- Volume
- 9
- Issue
- 8
- Pages
- 1736-1742
- ISSN
- 0903-1936 (ISSN-L)
- 1399-3003
- OpenAlex
- W2148972768
- Cited by
- 532
- References
- 27
- FWCI
- 3.65
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Drent, M., Cobben, N., Henderson, R., Wouters, E., & van Dieijen-Visser, M. (1996). Usefulness of lactate dehydrogenase and its isoenzymes as indicators of lung damage or inflammation. European Respiratory Journal. https://doi.org/10.1183/09031936.96.09081736
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
