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Muscle wasting and changes in muscle protein metabolism in chronic obstructive pulmonary disease
Open accessAbstract
Loss of skeletal muscle mass is now recognised as an important feature of chronic obstructive pulmonary disease (COPD) which contributes to symptoms and influences prognosis. The changes in skeletal muscle remain poorly understood, largely because only a few studies have been performed to define the adaptations in whole body and muscle protein metabolism in COPD. The first sections of this review summarise background information about skeletal muscle wasting in COPD, and focuses on the studies concerned with amino acid profiles and protein synthesis and degradation rates. To aid interpretation some discussion of the techniques commonly used is included. A variety of different catabolic factors may determine whether chronic obstructive pulmonary disease patients become cachectic. The precise role for each one of these factors as well as the intracellular pathways activated in muscle as a result of chronic obstructive pulmonary disease are unknown and remain to be defined. Details of the actions of a range of different catabolic factors and potential mechanisms will be discussed.
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“Alterations in amino acid (AA) profiles have been reviewed by Jagoe and Engelen [136] and include decreased glutamate and glutathione levels in COPD quadriceps [137].”
From Main Pathogenic Mechanisms and Recent Advances in COPD Peripheral Skeletal Muscle Wasting (2023) · cites this paper as [136]
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Cited by
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Chronic obstructive pulmonary disease
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Metadata
- Authors
- Jagoe, R. T., & Engelen, M. P. K. J.
- Affiliations
- Aintree University Hospital (GB)
- Maastricht University Medical Centre (NL)
- Venue
- European Respiratory Journal
- Publisher
- European Respiratory Society (ERS)
- Published
- 2003-11-02
- Volume
- 22
- Issue
- 46 suppl
- Pages
- 52s-63s
- ISSN
- 0903-1936 (ISSN-L)
- 1399-3003
- OpenAlex
- W2141973926
- Cited by
- 134
- References
- 134
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 5 · 2023: 6 · 2022: 3 · 2021: 6 · 2020: 1 · 2019: 4 · 2018: 7 · 2017: 5 · 2016: 4 · 2015: 8 · 2014: 7 · 2013: 6 · 2012: 5
- FWCI
- 1.96
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- European Respiratory Journal (publishedVersion)
- PubMed (publishedVersion)
- Research Publications (Maastricht University) (publishedVersion, other-oa)
- Research Publications (Maastricht University) (submittedVersion, other-oa)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Physiology (medical) › Nutrition and Health in Aging
- Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
- Keywords
- chronic obstructive pulmonary disease, muscle atrophy, skeletal muscle atrophy, muscle protein metabolism, protein synthesis, protein degradation, amino acid composition, cachexia, muscle catabolism
- MeSH terms
- Amino Acids, Animals, Humans, Muscle Proteins, Muscular Atrophy, Body Mass Index, Muscle, Skeletal, Inflammation Mediators, Pulmonary Disease, Chronic Obstructive
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