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The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.

Leptin and ghrelin levels in patients with obstructive sleep apnoea: effect of CPAP treatment

Open access
Harsch, I.A., Konturek, P.C., Koebnick, C., Kuehnlein, P.P., Fuchs, F.S., Pour Schahin, S., Wiest, G.H., Hahn, E.G., Lohmann, T., Ficker, J.H.·2003·European Respiratory Journal
DOI 10.1183/09031936.03.00010103
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Abstract

Serum leptin and ghrelin levels were investigated in patients with obstructive sleep apnoea (OSA) syndrome before and during continuous positive airways pressure (CPAP) treatment and compared with body mass index (BMI)-matched controls without OSA. Male patients (n=30) with OSA (apnoea/hypopnoea index=58±16, BMI=32.6±5.3 kg·m−2) underwent CPAP treatment. Fasting leptin and ghrelin were measured atbaseline and 2 days, and in the case of leptin 2 months after initiation of treatment. Baseline plasma ghrelin levels were significantly higher in OSA patients than in controls. After 2 days of CPAP treatment, plasma ghrelin decreased in almost all OSA patients (n=9) to levels that were only slightly higher than those of controls (n=9). Leptin levels did not change significantly from baseline after 2 days of CPAP treatment, but were higher than in the control group. After 8 weeks, leptin levels decreased significantly, although the BMI of the patients showed no change. The decrease in leptin levels was more pronounced in patients with a BMI <30 kg·m−2. These data indicate that the elevated leptin and ghrelin levels are not determined by obesity alone, since they rapidly decreased during continuous positive airways pressure therapy.

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Metadata

Authors
Harsch, I. A., Konturek, P. C., Koebnick, C., Kuehnlein, P. P., Fuchs, F. S., Pour Schahin, S., Wiest, G. H., Hahn, E. G., Lohmann, T., & Ficker, J. H.
Venue
European Respiratory Journal
Publisher
European Respiratory Society (ERS)
Published
2003-08
Volume
22
Issue
2
Pages
251-257
ISSN
  • 0903-1936 (ISSN-L)
  • 1399-3003
DOI
10.1183/09031936.03.00010103
OpenAlex
W2161879963
Cited by
286
References
46
FWCI
5.43
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Leptin and ghrelin levels in patients with obstructive sleep apnoea: effect of CPAP treatment. https://app.cochat.ai/papers/10.1183/09031936.03.00010103
The paper
Harsch, I. A., Konturek, P. C., Koebnick, C., Kuehnlein, P. P., Fuchs, F. S., Pour Schahin, S., Wiest, G. H., Hahn, E. G., Lohmann, T., & Ficker, J. H. (2003). Leptin and ghrelin levels in patients with obstructive sleep apnoea: effect of CPAP treatment. European Respiratory Journal. https://doi.org/10.1183/09031936.03.00010103

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.