The DOI matches its Crossref record; 72 of the 72 references it cites were found in a registry or an index.
Physical and biological triggers of ventilator-induced lung injury and its prevention
Open accessAbstract
Ventilator-induced lung injury is a side-effect of mechanical ventilation. Its prevention or attenuation implies knowledge of the sequence of events that lead from mechanical stress to lung inflammation and stress at rupture. A literature review was undertaken which focused on the link between the mechanical forces in the diseased lung and the resulting inflammation/rupture. The distending force of the lung is the transpulmonary pressure. This applied force, in a homogeneous lung, is shared equally by each fibre of the lung's fibrous skeleton. In a nonhomogeneous lung, the collapsed or consolidated regions do not strain, whereas the neighbouring fibres experience excessive strain. Indeed, if the global applied force is excessive, or the fibres near the diseased regions experience excessive stress/strain, biological activation and/or mechanical rupture are observed. Excessive strain activates macrophages and epithelial cells to produce interleukin‐8. This cytokine recruits neutrophils, with consequent full-blown inflammation. In order to prevent initiation of ventilator-induced lung injury, transpulmonary pressure must be kept within the physiological range. The prone position may attenuate ventilator-induced lung injury by increasing the homogeneity of transpulmonary pressure distribution. Positive end-expiratory pressure may prevent ventilator-induced lung injury by keeping open the lung, thus reducing the regional stress/strain maldistribution. If the transpulmonary pressure rather than the tidal volume per kilogram of body weight is taken into account, the contradictory results of the randomised trials dealing with different strategies of mechanical ventilation may be better understood.
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Cites
(2000) · New England Journal of Medicine · doi:10.1056/nejm200005043421801 · Cited by 12,941
Effect of a protective-ventilation strategy on mortality in the acute respiratory distress syndrome.
Amato, M. B. P., Barbas, C. S. V., Medeiros, D. M., Magaldi, R. B., Schettino, G. P., Lorenzi-Filho, G., Kairalla, R. A., Deheinzelin, D., Munoz, C., Oliveira, R., et al. (1998) · New England Journal of Medicine · doi:10.1056/nejm199802053380602 · Cited by 3,654
Ventilator-induced Lung Injury: Lessons from Experimental Studies
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Dreyfuss, D., Soler, P., Basset, G., & Saumon, G. (1988) · American Review of Respiratory Disease · doi:10.1164/ajrccm/137.5.1159 · Cited by 1,717
Stress distribution in lungs: a model of pulmonary elasticity.
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Self-citationEffect of prone positioning on the survival of patients with acute respiratory failure.
Gattinoni, L., Tognoni, G., Pesenti, A., Taccone, P., Mascheroni, D., Labarta, V., Malacrida, R., Di Giulio, P., Fumagalli, R., Pelosi, P., et al. (2001) · New England Journal of Medicine · doi:10.1056/nejmoa010043 · Cited by 1,271
Self-citationTidal ventilation at low airway pressures can augment lung injury.
Muscedere, J. G., Mullen, J. B., Gan, K., & Slutsky, A. S. (1994) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.149.5.8173774 · Cited by 1,244
Cytoskeletal regulation of pulmonary vascular permeability
Dudek, S. M., & Garcia, J. G. N. (2001) · Journal of Applied Physiology · doi:10.1152/jappl.2001.91.4.1487 · Cited by 985
Cited by
Lung recruitment in patients with the acute respiratory distress syndrome.
Gattinoni, L., Caironi, P., Cressoni, M., Chiumello, D., Ranieri, V. M., Quintel, M., Russo, S., Patroniti, N., Cornejo, R., & Bugedo, G. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa052052 · Cited by 1,548
Self-citationMechanical ventilation guided by esophageal pressure in acute lung injury.
Talmor, D., Sarge, T., Malhotra, A., O'Donnell, C. R., Ritz, R., Lisbon, A., Novack, V., & Loring, S. H. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0708638 · Cited by 1,149
A Multicenter Trial of Prolonged Prone Ventilation in Severe Acute Respiratory Distress Syndrome
Mancebo, J., Fernández, R., Blanch, L., Rialp, G., Gordo, F., Ferrer, M., Rodríguez, F., Garro, P., Ricart, P., Vallverdú, I., et al. (2006) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200503-353oc · Cited by 565
Esophageal and transpulmonary pressure in the clinical setting: meaning, usefulness and perspectives
Mauri, T., Yoshida, T., Bellani, G., Goligher, E. C., Carteaux, G., Rittayamai, N., Mojoli, F., Chiumello, D., Piquilloud, L., Grasso, S., et al. (2016) · Intensive Care Medicine · doi:10.1007/s00134-016-4400-x · Cited by 554
Self-citationTidal Volume Reduction in Patients with Acute Lung Injury When Plateau Pressures Are Not High
Hager, D. N., Krishnan, J. A., Hayden, D. L., & Brower, R. G. (2005) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200501-048cp · Cited by 509
Metadata
- Authors
- Gattinoni, L., Carlesso, E., Cadringher, P., Valenza, F., Vagginelli, F., & Chiumello, D.
- Venue
- European Respiratory Journal
- Publisher
- European Respiratory Society (ERS)
- Published
- 2003-11-16
- Volume
- 22
- Issue
- 47 suppl
- Pages
- 15s-25s
- ISSN
- 0903-1936 (ISSN-L)
- 1399-3003
- OpenAlex
- W2125351007
- Cited by
- 329
- References
- 72
- FWCI
- 7.57
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Gattinoni, L., Carlesso, E., Cadringher, P., Valenza, F., Vagginelli, F., & Chiumello, D. (2003). Physical and biological triggers of ventilator-induced lung injury and its prevention. European Respiratory Journal. https://doi.org/10.1183/09031936.03.00021303
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
