Exhaled nitric oxide from lung periphery is increased in COPD
Open accessAbstract
Single constant flow exhaled nitric oxide (eNO) cannot distinguish between the sources of NO. The present study measured eNO at multiple expired flows (MEFeNO) to partition NO into alveolar (Calv,NO) and bronchial (Jaw,NO) fractions to investigate peripheral lung contribution to eNO in chronic obstructive lung disease (COPD). MEFeNO were made in 81 subjects including 18 nonsmokers, 16 smokers and 47 COPD patients of different severity by the classification of the Global Initiative for Chronic Obstructive Lung Disease (GOLD): 0 (n = 14), 1 (n = 7), 2 (n = 11), 3 (n = 8) and 4 (n = 7). COPD severity was correlated with an increased Calv,NO regardless of the patient's smoking habit or current treatment. The levels of Calv,NO (in ppb) were 1.4+/-0.09 in nonsmokers, 2.1+/-0.1 in smokers categorised as GOLD stage 0 (smokers-GOLD0), 3.3+/-0.18 in GOLD1-2 and 3.4+/-0.1 in GOLD3-4. Jaw,NO levels (pL x s(-1)) were higher in nonsmokers than smokers-GOLD0 (716.2+/-33.3 versus 464.7+/-41.8), GOLD3-4 (609.4+/-71). Diffusion of NO in the airways (Daw,NO pL x ppb(-1) s(-1)) was higher (p<0.05) in GOLD3-4 than in nonsmokers (15+/-1.2 versus 11+/-0.5) and smokers-GOLD0 (11.6+/-0.5). MEFeNO measurements were reproducible, free from day-to-day and diurnal variation and were not affected by bronchodilators. In conclusion, chronic obstructive pulmonary disease is associated with elevated alveolar nitric oxide. Measurements of nitric oxide at multiple expired flows may be useful in monitoring inflammation and progression of chronic obstructive pulmonary disease, and the response to anti-inflammatory treatment.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Deleterious effects of NO on development of COPD might be derived from iNOS-mediated pro-inflammatory signaling, which is consequently reflected by the huge amount of NO in exhaled air of patients with COPD.
“However, the deleterious effects of NO on the development of COPD might be derived from iNOS-mediated pro-inflammatory signaling [128], which is consequently (not causally) reflected by the huge amount of NO in the exhaled air of patients with COPD [129].”
From NO-Rich Diet for Lifestyle-Related Diseases (2015) · cites this paper as [129]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
The Nature of Small-Airway Obstruction in Chronic Obstructive Pulmonary Disease
Hogg, J. C., Chu, F. S. F., Utokaparch, S., Woods, R. R., Elliott, W. M., Buzatu, L., Cherniack, R. M., Rogers, R. M., Sciurba, F. C., Coxson, H. O., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa032158 · Cited by 3,756 · see citing works
Increased nitric oxide in exhaled air of asthmatic patients
Kharitonov, S. A., Yates, D. H., Robbins, R. A., Barnes, P. J., Logan-Sinclair, R., & Shinebourne, E. A. (1994) · The Lancet · doi:10.1016/s0140-6736(94)90931-8 · Cited by 1,432 · see citing works
Exhaled Markers of Pulmonary Disease
Kharitonov, S. A., & Barnes, P. J. (2001) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.163.7.2009041 · Cited by 837 · see citing works
Fabbri, L. M., Romagnoli, M., Corbetta, L., Casoni, G. L., Busljetic, K., Turato, G., Ligabue, G., Ciaccia, A., Saetta, M. P., & Papi, A. A. (2003) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200203-183oc · Cited by 507 · see citing works
A two-compartment model of pulmonary nitric oxide exchange dynamics
Tsoukias, N. M., & George, S. C. (1998) · Journal of Applied Physiology · doi:10.1152/jappl.1998.85.2.653 · Cited by 477 · see citing works
Marked Flow-Dependence of Exhaled Nitric Oxide Using a New Technique to Exclude Nasal Nitric Oxide
Silkoff, P. E., McClean, P. A., Slutsky, A. S., Furlott, H., Hoffstein, E., Wakita, S., Chapman, K. R., Szalai, J. P., & Zamel, N. (1997) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.155.1.9001322 · Cited by 469 · see citing works
Increase in Reactive Nitrogen Species Production in Chronic Obstructive Pulmonary Disease Airways
Ichinose, M., Sugiura, H., Yamagata, S., Koarai, A., & Shirato, K. (2000) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.162.2.9908132 · Cited by 347 · see citing works
Exhaled Nitric Oxide in Chronic Obstructive Pulmonary Disease
Maziak, W., Loukides, S., Culpitt, S. V., SULLIVAN, P., Kharitonov, S. A., & Barnes, P. J. (1998) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.157.3.97-05009 · Cited by 323 · see citing works
Reproducibility of exhaled nitric oxide measurements in healthy and asthmatic adults and children
Kharitonov, S. A., Gonio, F., Kelly, C., Meah, S., & Barnes, P. J. (2003) · European Respiratory Journal · doi:10.1183/09031936.03.00066903a · Cited by 316 · see citing works
Increased Exhaled Nitric Oxide in Asthma Is Mainly Derived From the Lower Respiratory Tract
Kharitonov, S. A., Chung, K. F., Evans, D., O'Connor, B. J., & Barnes, P. J. (1996) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.153.6.8665033 · Cited by 286 · see citing works
Modeling pulmonary nitric oxide exchange
George, S. C., Högman, M., Permutt, S., & Silkoff, P. E. (2004) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00950.2003 · Cited by 244 · see citing works
Airway Nitric Oxide Diffusion in Asthma: Role in Pulmonary Function and Bronchial Responsiveness
Silkoff, P. E., SYLVESTER, J. T., Zamel, N., & Permutt, S. (2000) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.161.4.9903111 · Cited by 244 · see citing works
Extended Exhaled NO Measurement Differentiates between Alveolar and Bronchial Inflammation
Lehtimäki, L. A., Kankaanranta, H., Saarelainen, S., Hahtola, P., Järvenpää, R., Koivula, T. A., Turjanmaa, V., & Moilanen, E. (2001) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.163.7.2010171 · Cited by 186 · see citing works
Exhaled Carbon Monoxide and Nitric Oxide in COPD
Montuschi, P., Kharitonov, S. A., & Barnes, P. J. (2001) · CHEST Journal · doi:10.1378/chest.120.2.496 · Cited by 178 · see citing works
Maestrelli, P., Páska, C., Saetta, M. P., Turato, G., Nowicki, Y., Monti, S., Formichi, B. A., Miniati, M., & Fabbri, L. M. (2003) · European Respiratory Journal · doi:10.1183/09031936.03.00098203 · Cited by 144 · see citing works
Extended NO analysis applied to patients with COPD, allergic asthma and allergic rhinitis
Högman, M., Holmkvist, T., Wegener, T., Emtner, M., Andersson, M., Hedenström, H., & Meriläinen, P. (2002) · Respiratory Medicine · doi:10.1053/rmed.2001.1204 · Cited by 129 · see citing works
CIGARETTE SMOKE DECREASES INDUCIBLE NITRIC OXIDE SYNTHASE IN LUNG EPITHELIAL CELLS
Hoyt, J. C., Robbins, R., Habib, M. P., Springall, D. R., Buttery, L. D. K., Polak, J. M., & Barnes, P. J. (2003) · Experimental Lung Research · doi:10.1080/01902140303759 · Cited by 128 · see citing works
Increased alveolar nitric oxide concentration in asthmatic patients with nocturnal symptoms
Lehtimäki, L. A., Kankaanranta, H., Saarelainen, S. K., Turjanmaa, V., & Moilanen, E. (2002) · European Respiratory Journal · doi:10.1183/09031936.02.00202002 · Cited by 104 · see citing works
Tsoukias, N. M., Shin, H., Wilson, A. F., & George, S. C. (2001) · Journal of Applied Physiology · doi:10.1152/jappl.2001.91.1.477 · Cited by 96 · see citing works
Inhaled fluticasone decreases bronchial but not alveolar nitric oxide output in asthma
Lehtimäki, L. A., Kankaanranta, H., Saarelainen, S. K., Turjanmaa, V., & Moilanen, E. (2001) · European Respiratory Journal · doi:10.1183/09031936.01.00000201 · Cited by 95 · see citing works
Alveolar and Airway Sites of Nitric Oxide Inflammation in Treated Asthma
Gelb, A. F., Taylor, C. F., Nussbaum, E., Gutierrez, C., Schein, A. J., Shinar, C. M., Schein, M. J., Epstein, J. D., & Zamel, N. (2004) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200403-408oc · Cited by 91 · see citing works
Kharitonov, S. A., & Barnes, P. J. (2003) · Current Allergy and Asthma Reports · doi:10.1007/s11882-003-0024-7 · Cited by 90 · see citing works
Exhaled markers of inflammatory lung diseases: ready for routine monitoring?
Kharitonov, S. (2004) · Swiss Medical Weekly · doi:10.4414/smw.2004.10411 · Cited by 74 · see citing works
Lehtimäki, L. A., Turjanmaa, V., Kankaanranta, H., Saarelainen, S., Hahtola, P., & Moilanen, E. (2000) · Annals of Medicine · doi:10.3109/07853890008995949 · Cited by 64 · see citing works
Airway diffusing capacity of nitric oxide and steroid therapy in asthma
Shin, H., Rose-Gottron, C. M., Cooper, D. M., Newcomb, R. L., & George, S. C. (2004) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00575.2003 · Cited by 48 · see citing works
Straaten, J. F. M. V., Postma, D. S., Coers, W., Noordhoek, J., Kauffman, H. F., & Timens, W. (1998) · PubMed · Cited by 39 · see citing works
Secondhand Tobacco Smoke Impairs Rabbit Pulmonary Artery Endothelium-Dependent Relaxation
Hutchison, S. J., Sievers, R. E., Zhu, B., Sun, Y., Stewart, D. J., Parmley, W. W., & Chatterjee, K. (2001) · CHEST Journal · doi:10.1378/chest.120.6.2004 · Cited by 38 · see citing works
Flow-independent nitric oxide exchange parameters in healthy adults
Shin, H., Rose-Gottron, C. M., Perez, F., Cooper, D. M., Wilson, A. F., & George, S. C. (2001) · Journal of Applied Physiology · doi:10.1152/jappl.2001.91.5.2173 · Cited by 31 · see citing works
Exhaled Nitric Oxide and Exercise in Stable COPD Patients
Clini, E. M., Bianchi, L. N. C., Vitacca, M., Porta, R., Foglio, K., & Ambrosino, N. (2000) · CHEST Journal · doi:10.1378/chest.117.3.702 · Cited by 28 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Outcomes for COPD pharmacological trials: from lung function to biomarkers
Cazzola, M., MacNee, W., Martínez, F. J., Rabe, K. F., Franciosi, L. G., Barnes, P. J., Brusasco, V., Burge, P. S., Calverley, P. M., Celli, B. R., et al. (2008) · European Respiratory Journal · doi:10.1183/09031936.00099306 · Cited by 843 · see citing works
How corticosteroids control inflammation: Quintiles Prize Lecture 2005
Barnes, P. J. (2006) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706736 · Cited by 842 · see citing works
Exhaled nitric oxide measurements: clinical application and interpretation
Taylor, D. R., Pijnenburg, M. W., Smith, A. D., & Jongste, J. C. D. (2006) · Thorax · doi:10.1136/thx.2005.056093 · Cited by 507 · see citing works
Exacerbations of chronic obstructive pulmonary disease
Celli, B. R., & Barnes, P. J. (2007) · European Respiratory Journal · doi:10.1183/09031936.00109906 · Cited by 460 · see citing works
Exhaled Nitric Oxide in Pulmonary Diseases
Barnes, P. J., Dweik, R. A., Gelb, A. F., Gibson, P. G., George, S. C., Grasemann, H., Pavord, I. D., Ratjen, F. A., Silkoff, P. E., Taylor, D. R., et al. (2010) · CHEST Journal · doi:10.1378/chest.09-2090 · Cited by 393 · see citing works
Role of HDAC2 in the Pathophysiology of COPD
Barnes, P. J. (2008) · Annual Review of Physiology · doi:10.1146/annurev.physiol.010908.163257 · Cited by 322 · see citing works
Pulmonary Biomarkers in Chronic Obstructive Pulmonary Disease
Barnes, P. J., Chowdhury, B. A., Kharitonov, S. A., MAGNUSSEN, H., Page, C. P., Postma, D. S., & Saetta, M. P. (2006) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200510-1659pp · Cited by 297 · see citing works
Consensus Document on the Overlap Phenotype COPD–Asthma in COPD
Soler‐Cataluña, J. J., Cosío, B. G., Alonso, J. L. I., López-Campos, J. L., Marín, J. M., Agüero, R., Baloira, A., Carrizo, S. J., Esteban, C., Gáldiz, J. B., et al. (2012) · Archivos de Bronconeumología · doi:10.1016/j.arbr.2012.06.017 · Cited by 264 · see citing works
Documento de consenso sobre el fenotipo mixto EPOC-asma en la EPOC
Soler‐Cataluña, J. J., Cosío, B. G., Alonso, J. L. I., López-Campos, J. L., Marín, J. M., Agüero, R., Baloira, A., Carrizo, S. J., Esteban, C., Gáldiz, J. B., et al. (2012) · Archivos de Bronconeumología · doi:10.1016/j.arbres.2011.12.009 · Cited by 237 · see citing works
A protein deacetylase SIRT1 is a negative regulator of metalloproteinase‐9
Nakamaru, Y., Vuppusetty, C., Wada, H., Milne, J. C., Ito, M., Rossios, C., Elliot, M., Hogg, J. C., Kharitonov, S. A., Goto, H., et al. (2009) · The FASEB Journal · doi:10.1096/fj.08-125468 · Cited by 224 · see citing works
Experimental exposure to wood smoke: effects on airway inflammation and oxidative stress
Barregård, L., Sällsten, G., Andersson, L., Almstrand, A., Gustafson, P., Andersson, M., & Olin, A. (2007) · Occupational and Environmental Medicine · doi:10.1136/oem.2006.032458 · Cited by 205 · see citing works
Kharitonov, S. A., & Barnes, P. J. (2006) · CHEST Journal · doi:10.1378/chest.130.5.1541 · Cited by 202 · see citing works
The small airways and distal lung compartment in asthma and COPD: a time for reappraisal
Contoli, M., Bousquet, J., Fabbri, L. M., MAGNUSSEN, H., Rabe, K. F., Siafakas, N. M., Hamid, Q. A., & Kraft, M. (2009) · Allergy · doi:10.1111/j.1398-9995.2009.02242.x · Cited by 171 · see citing works
Reduced histone deacetylase in COPD: clinical implications.
Barnes, P. (2006) · Chest · doi:10.1378/chest.129.1.151 · Cited by 164 · see citing works
Nitration of distinct tyrosine residues causes inactivation of histone deacetylase 2
Osoata, G. O., Yamamura, S., Ito, M., Vuppusetty, C., Adcock, I. M., Barnes, P. J., & Ito, K. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.04.128 · Cited by 157 · see citing works
Reference values for exhaled nitric oxide (reveno) study
Olivieri, M., Talamini, G., Corradi, M., Perbellini, L., Mutti, A., Tantucci, C., & Malerba, M. (2006) · Respiratory Research · doi:10.1186/1465-9921-7-94 · Cited by 151 · see citing works
Arginase and pulmonary diseases
Maarsingh, H., Pera, T., & Meurs, H. (2008) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-008-0286-7 · Cited by 145 · see citing works
Histone deacetylase-2 and airway disease
Barnes, P. J. (2009) · Therapeutic Advances in Respiratory Disease · doi:10.1177/1753465809348648 · Cited by 127 · see citing works
Zhang, X., Staimer, N., Gillen, D. L., Tjoa, T., Schauer, J. J., Shafer, M. M., Hasheminassab, S., Pakbin, P., Vaziri, N. D., Sioutas, C., et al. (2016) · Environmental Research · doi:10.1016/j.envres.2016.06.019 · Cited by 126 · see citing works
Brindicci, C., Kharitonov, S. A., Ito, M., Elliott, M. W., Hogg, J. C., Barnes, P. J., & Ito, K. (2009) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200904-0493oc · Cited by 113 · see citing works
Exhaled Nitric Oxide as a Biomarker in COPD and Related Comorbidities
Malerba, M., Radaeli, A., Olivini, A., Damiani, G., Ragnoli, B., Montuschi, P., & Ricciardolo, F. L. M. (2014) · BioMed Research International · doi:10.1155/2014/271918 · Cited by 106 · see citing works
Williamson, P. A., Clearie, K. L., Menzies, D., Vaidyanathan, S., & Lipworth, B. J. (2010) · Lung · doi:10.1007/s00408-010-9275-y · Cited by 105 · see citing works
Techniques for assessing small airways function: Possible applications in asthma and COPD
Κatsoulis, Κ., Κostikas, Κ., & Kontakiotis, T. (2013) · Respiratory Medicine · doi:10.1016/j.rmed.2013.05.003 · Cited by 100 · see citing works
Inhibition of inducible nitric oxide synthase in respiratory diseases
Heßlinger, C., Strub, A., Boer, R., Ulrich, W., Lehner, M. D., & Braun, C. (2009) · Biochemical Society Transactions · doi:10.1042/bst0370886 · Cited by 98 · see citing works
Bonini, M., & Usmani, O. S. (2015) · Therapeutic Advances in Respiratory Disease · doi:10.1177/1753465815588064 · Cited by 97 · see citing works
NO-Rich Diet for Lifestyle-Related Diseases
Kobayashi, J., Ohtake, K., & Uchida, H. (2015) · Nutrients · doi:10.3390/nu7064911 · Cited by 94 · see citing works
Peroxynitrite Elevation in Exhaled Breath Condensate of COPD and Its Inhibition by Fudosteine
Osoata, G. O., Hanazawa, T., Brindicci, C., Ito, M., Barnes, P. J., Ito, K., & Ito, K. (2009) · CHEST Journal · doi:10.1378/chest.08-2105 · Cited by 87 · see citing works
Lu, Z., Huang, W., Wang, L., Xu, N., Ding, Q., & Cao, C. (2018) · International Journal of COPD · doi:10.2147/copd.s165780 · Cited by 84 · see citing works
Breath biomarkers in diagnosis of pulmonary diseases
Zhou, M., Liu, Y., & Duan, Y. (2012) · Clinica Chimica Acta · doi:10.1016/j.cca.2012.07.006 · Cited by 81 · see citing works
Kinnula, V. L. (2008) · International Journal of COPD · doi:10.2147/copd.s3671 · Cited by 80 · see citing works
Methods of NO detection in exhaled breath
Cristescu, S. M., Mandon, J., Harren, F. J. M., Meriläinen, P., & Högman, M. (2013) · Journal of Breath Research · doi:10.1088/1752-7155/7/1/017104 · Cited by 79 · see citing works
Differential Flow Analysis of Exhaled Nitric Oxide in Patients With Asthma of Differing Severity
Brindicci, C., Ito, K., Barnes, P. J., & Kharitonov, S. A. (2007) · CHEST Journal · doi:10.1378/chest.06-2531 · Cited by 78 · see citing works
Redington, A. E. (2006) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2005.12.069 · Cited by 77 · see citing works
New developments in the assessment of COPD: early diagnosis is key
Gartman, E. J., & Csikesz, N. G. (2014) · International Journal of COPD · doi:10.2147/copd.s46198 · Cited by 77 · see citing works
Navarrete, B. A., Rodríguez, O. R., Baena, P. C., Romero, P., & Agustí, A. G. N. (2018) · European Respiratory Journal · doi:10.1183/13993003.01457-2017 · Cited by 75 · see citing works
Metal oxide‐based gas sensors for the detection of exhaled breath markers
Vajhadin, F., Mazloum‐Ardakani, M., & Amini, A. (2020) · Medical Devices & Sensors · doi:10.1002/mds3.10161 · Cited by 74 · see citing works
Cazzola, M., & Novelli, G. (2010) · Pulmonary Pharmacology & Therapeutics · doi:10.1016/j.pupt.2010.05.001 · Cited by 72 · see citing works
Sansone, F., Aquino, R. P., Gaudio, P. D., Colombo, P., & Russo, P. (2008) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2008.10.007 · Cited by 72 · see citing works
Lehtonen, H., Oksa, P., Lehtimäki, L. A., Sepponen-Lavikko, A., Nieminen, R., Kankaanranta, H., Saarelainen, S. K., Järvenpää, R., Uitti, J., & Moilanen, E. (2007) · Thorax · doi:10.1136/thx.2006.067868 · Cited by 70 · see citing works
Eosinophils, basophils and type 2 immune microenvironments in COPD-affected lung tissue
Jogdand, P. S., Siddhuraj, P., Mori, M., Sandén, C., Jönsson, J., Walls, A. F., Kearley, J., Humbles, A. A., Kolbeck, R., Bjermer, L. H., et al. (2020) · European Respiratory Journal · doi:10.1183/13993003.00110-2019 · Cited by 67 · see citing works
Partitioned exhaled nitric oxide to non-invasively assess asthma
Puckett, J. L., & George, S. C. (2008) · Respiratory Physiology & Neurobiology · doi:10.1016/j.resp.2008.07.020 · Cited by 67 · see citing works
Liu, F., Li, W., Pauluhn, J., Trübel, H., & Wang, C. (2013) · Toxicology · doi:10.1016/j.tox.2012.12.020 · Cited by 66 · see citing works
Trueba, A. F., Smith, N. B., Auchus, R. J., & Ritz, T. (2013) · Biological Psychology · doi:10.1016/j.biopsycho.2013.01.017 · Cited by 65 · see citing works
Lin, J.-L., & Thomas, P. S. (2010) · COPD Journal of Chronic Obstructive Pulmonary Disease · doi:10.3109/15412555.2010.496818 · Cited by 65 · see citing works
Nitric Oxide and Exhaled Breath Nitrite/Nitrates in Chronic Obstructive Pulmonary Disease Patients
Stevens, J. L., Sandrini, A., Thurston, M. C., Yates, D. H., & Thomas, P. S. (2007) · Respiration · doi:10.1159/000106379 · Cited by 64 · see citing works
Chronic obstructive pulmonary disease and atherosclerosis: common mechanisms and novel therapeutics
Brassington, K., Selemidis, S., Bozinovski, S., & Vlahos, R. (2022) · Clinical Science · doi:10.1042/cs20210835 · Cited by 65 · see citing works
Exhaled nitric oxide parameters and functional capacity in chronic obstructive pulmonary disease
McCurdy, M. R., Sharafkhaneh, A., Abdel‐Monem, H., Rojo, J., & Tittel, F. K. (2011) · Journal of Breath Research · doi:10.1088/1752-7155/5/1/016003 · Cited by 61 · see citing works
Charron, C. E., Chou, P.-C., Coutts, D. J. C., Kumar, V., To, M., Akashi, K., Pinhu, L., Griffiths, M., Adcock, I. M., Barnes, P. J., et al. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.025387 · Cited by 61 · see citing works
Pulmonary biomarkers in COPD exacerbations: a systematic review
Koutsokera, A., Κostikas, Κ., Nicod, L. P., & Fitting, J.-W. (2013) · Respiratory Research · doi:10.1186/1465-9921-14-111 · Cited by 60 · see citing works
Quantum cascade laser-based integrated cavity output spectroscopy of exhaled nitric oxide
McCurdy, M. R., Bakhirkin, Y. A., & Tittel, F. K. (2006) · Applied Physics B · doi:10.1007/s00340-006-2365-0 · Cited by 59 · see citing works
Exhaled nitric oxide in diagnosis and management of respiratory diseases
Abba, A. A. (2009) · Annals of Thoracic Medicine · doi:10.4103/1817-1737.56009 · Cited by 59 · see citing works
Lipopolysaccharide Challenge of Humans as a Model for Chronic Obstructive Lung Disease Exacerbations
Kharitonov, S. A., & bring, U. S. O. (2007) · KARGER eBooks · doi:10.1159/000107056 · Cited by 56 · see citing works
Brindicci, C., Ito, K., Torre, O., Barnes, P. J., & Kharitonov, S. A. (2008) · CHEST Journal · doi:10.1378/chest.08-0964 · Cited by 55 · see citing works
A Novel Approach to Partition Central and Peripheral Airway Nitric Oxide
Paredi, P., Kharitonov, S. A., Meah, S., Barnes, P. J., & Usmani, O. S. (2013) · CHEST Journal · doi:10.1378/chest.13-0843 · Cited by 54 · see citing works
Bronchial nitric oxide is related to symptom relief during fluticasone treatment in COPD
Lehtimäki, L. A., Kankaanranta, H., Saarelainen, S. K., Annila, I., Aine, T., Nieminen, R., & Moilanen, E. (2009) · European Respiratory Journal · doi:10.1183/09031936.00177508 · Cited by 53 · see citing works
Use of different exhaled nitric oxide multiple flow rate models in COPD
Roy, K. C., Borrill, Z., Starkey, C., Hazel, A. L., Morris, J., Vestbo, J., & Singh, D. (2007) · European Respiratory Journal · doi:10.1183/09031936.00149706 · Cited by 50 · see citing works
The Relevance of Targeting Treatment to Small Airways in Asthma and COPD
Santus, P., Radovanovic, D., Pecchiari, M., Ferrando, M., Tursi, F., Patella, V., & Braido, F. (2020) · Respiratory Care · doi:10.4187/respcare.07237 · Cited by 48 · see citing works
The clinical utility of biomarkers in asthma and COPD
Snell, N. J. C., & Newbold, P. (2008) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2008.04.001 · Cited by 47 · see citing works
Role of the nitric oxide–soluble guanylyl cyclase pathway in obstructive airway diseases
Dupont, L. L., Glynos, C., Bracke, K. R., Brouckaert, P., & Brusselle, G. (2014) · Pulmonary Pharmacology & Therapeutics · doi:10.1016/j.pupt.2014.07.004 · Cited by 46 · see citing works
Extended NO analysis in health and disease
Högman, M. (2012) · Journal of Breath Research · doi:10.1088/1752-7155/6/4/047103 · Cited by 46 · see citing works
Brindicci, C., Ito, K., Barnes, P. J., & Kharitonov, S. A. (2007) · CHEST Journal · doi:10.1378/chest.06-3046 · Cited by 45 · see citing works
Extended NO analysis in asthma
Högman, M., & Meriläinen, P. (2007) · Journal of Breath Research · doi:10.1088/1752-7155/1/2/024001 · Cited by 43 · see citing works
Hirano, T., Matsunaga, K., Sugiura, H., Minakata, Y., Koarai, A., Akamatsu, K., Ichikawa, T., Furukawa, K., & Ichinose, M. (2013) · Journal of Breath Research · doi:10.1088/1752-7155/7/4/046002 · Cited by 42 · see citing works
Defining Disease Modification in Chronic Obstructive Pulmonary Disease
Halpin, D., & Tashkin, D. (2009) · COPD · doi:10.1080/15412550902918402 · Cited by 44 · see citing works
Alveolar-Derived Exhaled Nitric Oxide Is Reduced in Obstructive Sleep Apnea Syndrome
Foresi, A., Leone, C., Olivieri, D., & Cremona, G. (2007) · CHEST Journal · doi:10.1378/chest.06-3124 · Cited by 40 · see citing works
Utility of exhaled nitric oxide as a noninvasive biomarker of lung inflammation in a disease model
Birrell, M. A., McCluskie, K., Hardaker, E. L., Knowles, R. G., & Belvisi, M. G. (2006) · European Respiratory Journal · doi:10.1183/09031936.00048506 · Cited by 36 · see citing works
Exhaled nitric oxide in stable chronic obstructive pulmonary disease
Abba, A., Beg, M. S., Alzoghaibi, M. A., & Ss, H. (2009) · Annals of Thoracic Medicine · doi:10.4103/1817-1737.44649 · Cited by 35 · see citing works
Extended NO analysis in a healthy subgroup of a random sample from a Swedish population
Högman, M., Lafih, J., Meriläinen, P., Bröms, K., Malinovschi, A., & Janson, C. (2008) · Clinical Physiology and Functional Imaging · doi:10.1111/j.1475-097x.2008.00831.x · Cited by 35 · see citing works
Exhaled Biomarkers for Point-of-Care Diagnosis: Recent Advances and New Challenges in Breathomics
Kiss, H., Örlős, Z., Gellert, Á., Megyesfalvi, Z., Mikáczó, A., Sárközi, A. T., Vaskó, A., Miklós, Z., & Horváth, I. (2023) · Micromachines · doi:10.3390/mi14020391 · Cited by 34 · see citing works
Advances in the clinical applications of exhaled nitric oxide measurements
Taylor, D. R. (2012) · Journal of Breath Research · doi:10.1088/1752-7155/6/4/047102 · Cited by 34 · see citing works
Increased Nitric Oxide Concentrations in the Small Airway of Older Normal Subjects
Gelb, A. F., George, S. C., Camacho, F., Fraser, C., Taylor, C. F., & Shakkottai, S. (2010) · CHEST Journal · doi:10.1378/chest.10-1157 · Cited by 34 · see citing works
Biomarkers in the assessment and management of airways diseases
Taylor, D. R., & Pavord, I. D. (2008) · Postgraduate Medical Journal · doi:10.1136/pgmj.2008.069864 · Cited by 33 · see citing works
Review of exhaled nitric oxide in chronic obstructive pulmonary disease
Gelb, A. F., Barnes, P. J., George, S. C., Ricciardolo, F. L. M., DiMaria, G., & Zamel, N. (2012) · Journal of Breath Research · doi:10.1088/1752-7155/6/4/047101 · Cited by 32 · see citing works
Lee, J. S., Shin, J. H., Hwang, J.-H., Baek, J. E., & Choi, B.-S. (2014) · Safety and Health at Work · doi:10.1016/j.shaw.2014.03.001 · Cited by 32 · see citing works
Lázár, Z., Kelemen, Á., Gálffy, G., Losonczy, G., Horváth, I., & Bikov, A. (2018) · Journal of Breath Research · doi:10.1088/1752-7163/aac10a · Cited by 31 · see citing works
Application of nitric oxide measurements in clinical conditions beyond asthma
Malinovschi, A., Lúðvíksdóttir, D., Tufvesson, E., Rolla, G., Bjermer, L. H., Alving, K., & Diamant, Z. (2015) · European Clinical Respiratory Journal · doi:10.3402/ecrj.v2.28517 · Cited by 30 · see citing works
Idh, J., Westman, A., Eliáš, D., Moges, F., Getachew, A., Gelaw, A., Sundqvist, T., Forslund, T., Alemu, A., Ayele, B. A., et al. (2008) · BMC Infectious Diseases · doi:10.1186/1471-2334-8-146 · Cited by 29 · see citing works
Pulmonary inflammation in asbestos-exposed subjects with borderline parenchymal changes on HRCT
Lehtimäki, L. A., Oksa, P., Järvenpää, R., Vierikko, T., Nieminen, R. M., Kankaanranta, H., Uitti, J., & Moilanen, E. (2010) · Respiratory Medicine · doi:10.1016/j.rmed.2010.01.019 · Cited by 28 · see citing works
Högman, M., Lehtimäki, L. A., & Dinh‐Xuan, A. T. (2017) · Expert Review of Respiratory Medicine · doi:10.1080/17476348.2017.1281746 · Cited by 28 · see citing works
Hillas, G., Loukides, S., Κostikas, Κ., & Bakakos, P. (2009) · Current Medicinal Chemistry · doi:10.2174/092986709788803178 · Cited by 27 · see citing works
Measurement of exhaled nitric oxide concentration in patients with obstructive sleep apnea
Zhang, D., Luo, J., Qiao, Y., Xiao, Y., Huang, R., & Zhong, X. (2017) · Medicine · doi:10.1097/md.0000000000006429 · Cited by 27 · see citing works
Role of nitric oxide synthases in elastase-induced emphysema
Boyer, L., Plantier, L., Dagouassat, M., Lanone, S., Goven, D., Caramelle, P., Berrehar, F., Kerbrat, S., Dinh‐Xuan, A. T., Crestani, B., et al. (2010) · Laboratory Investigation · doi:10.1038/labinvest.2010.169 · Cited by 27 · see citing works
NO donors and NO delivery methods for controlling biofilms in chronic lung infections
Cai, Y.-M., Zhang, Y., & Yang, L. (2021) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-021-11274-2 · Cited by 26 · see citing works
Sun, Y., Wang, X.-M., Chen, Y., Rui-xia, Z. H. U., & Cheng-cheng, L. I. A. O. (2013) · Chinese Medical Journal · doi:10.3760/cma.j.issn.0366-6999.20123064 · Cited by 26 · see citing works
Högman, M., Thornadtsson, A., Liv, P., Hua-Huy, T., Dinh‐Xuan, A. T., Tufvesson, E., Dressel, H., Janson, C., Koskela, K., Oksa, P., et al. (2017) · Journal of Breath Research · doi:10.1088/1752-7163/aa7957 · Cited by 26 · see citing works
Kikuchi, H., Shiozawa, N., Takata, S., Ashida, K., & Mitsunobu, F. (2013) · International Journal of COPD · doi:10.2147/copd.s50860 · Cited by 25 · see citing works
Kuo, W.-K., Liu, J. Y.-C., Chu, C., Hua, C., Huang, C.-Y., Liu, M., & Wang, C. (2019) · International Journal of COPD · doi:10.2147/copd.s220557 · Cited by 24 · see citing works
Fan, X., Zhao, N., Yu, Z., Yu, H., Yin, B., Zou, L., Zhao, Y., Qian, X.-F., Sai, X., Qin, C., et al. (2021) · International Journal of General Medicine · doi:10.2147/ijgm.s284688 · Cited by 24 · see citing works
Central and Peripheral Airway Sites of Nitric Oxide Gas Exchange in COPD
Gelb, A. F., Taylor, C. F., Krishnan, A., Fraser, C., Shinar, C. M., Schein, M. J., & Osann, K. (2009) · CHEST Journal · doi:10.1378/chest.09-1522 · Cited by 24 · see citing works
Chronic Obstructive Pulmonary Disease (COPD)
Barnes, P. J. (2012) · Chemical biology · doi:10.1002/9781118435762.ch13 · Cited by 24 · see citing works
Repeatability of exhaled nitric oxide measurements in patients with COPD
Rouhos, A., Kainu, A., Piirilä, P. L., Sarna, S. J., Lindqvist, A. E., Karjalainen, J., & Sovijärvi, A. R. A. (2010) · Clinical Physiology and Functional Imaging · doi:10.1111/j.1475-097x.2010.00975.x · Cited by 23 · see citing works
Obregon, C., Graf, L., Chung, K. F., Cesson, V., & Nicod, L. P. (2015) · PLoS ONE · doi:10.1371/journal.pone.0120134 · Cited by 22 · see citing works
Peck, M. J., Sanders, E. B., Scherer, G., Lüdicke, F., & Weitkunat, R. (2018) · Biomarkers · doi:10.1080/1354750x.2017.1419284 · Cited by 21 · see citing works
The State of the Nitric Oxide Cycle in Respiratory Tract Diseases
Келдибековна, С. С., Klimanov, I. A., Kubysheva, N. I., Попова, Н. А., & Batyrshin, I. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/4859260 · Cited by 24 · see citing works
History, technical and regulatory aspects of exhaled nitric oxide
Silkoff, P. E. (2008) · Journal of Breath Research · doi:10.1088/1752-7155/2/3/037001 · Cited by 22 · see citing works
Physiologic similarities and differences between asthma and chronic obstructive pulmonary disease
Gelb, A. F., Zamel, N., & Krishnan, A. (2007) · Current Opinion in Pulmonary Medicine · doi:10.1097/mcp.0b013e3282f197df · Cited by 22 · see citing works
The Value of Sputum 8-Isoprostane in Detecting Oxidative Stress in Mild Asthma
Louhelainen, N., Rytilä, P. H., Obase, Y., Mäkelä, M. J., Haahtela, T., Kinnula, V. L., & Pelkonen, A. S. (2008) · Journal of Asthma · doi:10.1080/02770900701840261 · Cited by 22 · see citing works
Exhaled nitric oxide measure using multiple flows in clinically relevant subgroups of COPD
Roberts, N. B., Gerds, T. A., Budtz–Jørgensen, E., Hove, J. D., & Vestbo, J. (2011) · Respiratory Medicine · doi:10.1016/j.rmed.2011.03.015 · Cited by 21 · see citing works
Alveolar and bronchial exhaled nitric oxide in chronic obstructive pulmonary disease
Lehouck, A., Carremans, C., Bent, K. D., Decramer, M., & Janssens, W. (2010) · Respiratory Medicine · doi:10.1016/j.rmed.2010.01.001 · Cited by 21 · see citing works
Jiang, W., Liu, X., Xu, Y., Wang, N., & Chen, S. (2015) · Chinese Medical Journal · doi:10.4103/0366-6999.158309 · Cited by 21 · see citing works
- Authors
- Brindicci, C., Ito, K., Resta, O., Pride, N. B., Barnes, P. J., & Kharitonov, S. A.
- Affiliations
- Imperial College London (GB)
- University of Bari Aldo Moro (IT)
- Corresponding author
- Kharitonov, S. A.
- Venue
- European Respiratory Journal
- Publisher
- European Respiratory Society (ERS)
- Published
- 2005-07
- Volume
- 26
- Issue
- 1
- Pages
- 52-59
- ISSN
- 0903-1936 (ISSN-L)
- 1399-3003
- OpenAlex
- W2164167422
- Cited by
- 206
- References
- 29
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 3 · 2023: 4 · 2022: 4 · 2021: 4 · 2020: 8 · 2019: 6 · 2018: 11 · 2017: 6 · 2016: 3 · 2015: 9 · 2014: 5 · 2013: 14 · 2012: 14
- FWCI
- 11.90
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- European Respiratory Journal (publishedVersion)
- PubMed (publishedVersion)
- CINECA IRIS Institutional Research Information System (University of Bari Aldo Moro) (submittedVersion)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
- Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
- Physical Sciences › Engineering › Biomedical Engineering › Advanced Chemical Sensor Technologies
- Keywords
- exhaled nitric oxide, chronic obstructive pulmonary disease, alveolar nitric oxide, COPD severity, smoking, airway inflammation
- MeSH terms
- Adult, Aged, Analysis of Variance, Female, Forced Expiratory Volume, Humans, Male, Middle Aged, Nitric Oxide, Probability, Prognosis, Reference Values, Respiratory Function Tests, Sensitivity and Specificity, Severity of Illness Index, Smoking, Cohort Studies, Biomarkers, Case-Control Studies, Risk Assessment, Statistics, Nonparametric, Pulmonary Disease, Chronic Obstructive, Exhalation
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
