The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
Risk factors of frequent exacerbations in difficult-to-treat asthma
Open accessAbstract
Recurrent exacerbations are a major cause of morbidity and medical expenditure in patients with asthma. Various exogenous and endogenous factors are thought to influence the level of asthma control, but systematical data on the involvement of these factors in the recurrence of asthma exacerbations are scarce. In this study, 13 clinical and environmental factors potentially associated with recurrent exacerbations were investigated in 136 patients with difficult-to-treat asthma. Patients with more than three severe exacerbations (n = 39) in the previous year were compared with those with only one exacerbation per year (n = 24). A systematic diagnostic protocol was used to assess 13 potential risk factors. Factors significantly associated with frequent exacerbations included: severe nasal sinus disease (adjusted odds ratio (OR) 3.7); gastro-oesophageal reflux (OR 4.9); recurrent respiratory infections (OR 6.9); psychological dysfunctioning (OR 10.8); and obstructive sleep apnoea (OR 3.4). Severe chronic sinus disease and psychological dysfunctioning were the only independently associated factors (adjusted OR 5.5 and 11.7, respectively). All patients with frequent exacerbations exhibited at least one of these five factors, whilst 52% showed three or more factors. In conclusion, the results show that recurrent exacerbations in asthma are associated with specific co-morbid factors that are easy to detect and that are treatable. Therapeutic interventions aimed at correcting these factors are likely to reduce morbidity and medical expenditure in these patients.
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Cites
Lung volumes and forced ventilatory flows
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Respiratory viruses and exacerbations of asthma in adults
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Self-citationInadequate Literacy Is a Barrier to Asthma Knowledge and Self-Care
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Factors Associated with Persistent Airflow Limitation in Severe Asthma
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Cited by
International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma
Chung, K. F., Wenzel, S. E., Brozek, J. L., Bush, A., Castro, M., Sterk, P. J., Adcock, I. M., Bateman, E. D., Bel, E. H., Bleecker, E. R., et al. (2014) · European Respiratory Journal · doi:10.1183/09031936.00202013 · Cited by 3,926
Self-citationReddel, H. K., Taylor, D. R., Bateman, E. D., Boulet, L.-P., Boushey, H. A., Busse, W. W., Casale, T. B., Chanez, P., Enright, P. L., Gibson, P. G., et al. (2009) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200801-060st · Cited by 1,918
Self-citationClarke, D. M., & Currie, K. C. (2009) · Medical Journal of Australia · doi:10.5694/j.1326-5377.2009.tb02471.x · Cited by 661
Asthma in adults and its association with chronic rhinosinusitis: The GA 2 LEN survey in Europe
Jarvis, D., Newson, R., Lotvall, J., Hastan, D., Tomassen, P., Keil, T., Gjomarkaj, M., Forsberg, B., Gunnbjornsdottir, M., Minov, J., et al. (2012) · Allergy · doi:10.1111/j.1398-9995.2011.02709.x · Cited by 485
Inflammatory and Comorbid Features of Patients with Severe Asthma and Frequent Exacerbations
Denlinger, L. C., Phillips, B. R., Ramratnam, S., Ross, K., Bhakta, N. R., Cardet, J. C., Castro, M., Peters, S. P., Phipatanakul, W., Aujla, S., et al. (2017) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201602-0419oc · Cited by 435
Metadata
- Authors
- ten Brinke, A., Sterk, P. J., Masclee, A. A. M., Spinhoven, P., Schmidt, J. T., Zwinderman, A. H., Rabe, K. F., & Bel, E. H.
- Venue
- European Respiratory Journal
- Publisher
- European Respiratory Society (ERS)
- Published
- 2005-11
- Volume
- 26
- Issue
- 5
- Pages
- 812-818
- ISSN
- 0903-1936 (ISSN-L)
- 1399-3003
- OpenAlex
- W2104718344
- Cited by
- 490
- References
- 39
- FWCI
- 10.77
- Type
- journal article
- Language
- en
- Open access
- bronze
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- ten Brinke, A., Sterk, P. J., Masclee, A. A. M., Spinhoven, P., Schmidt, J. T., Zwinderman, A. H., Rabe, K. F., & Bel, E. H. (2005). Risk factors of frequent exacerbations in difficult-to-treat asthma. European Respiratory Journal. https://doi.org/10.1183/09031936.05.00037905
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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