The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
Dose-dependent cigarette smoking-related inflammatory responses in healthy adults
Abstract
The aim of this study was to determine the dose-response relationship between cigarette smoke exposure and pulmonary cell and cytokine concentrations in bronchoalveolar lavage (BAL). BAL cells and BAL supernatant concentrations of tumour necrosis factor-alpha (TNF alpha), interleukin (IL)-1 beta, IL-6, IL-8, and monocyte chemoattractant protein (MCP)-1 from 14 healthy smokers and 16 healthy nonsmokers were quantified. Statistically greater concentrations of neutrophils, macrophages, IL-1 beta, IL-6, IL-8 and MCP-1 were observed among smokers compared with nonsmokers (p < or = 0.0007 in all cases). Cigarette smoking, categorized ordinally as: less than one pack, one pack, or greater than one pack per day, was predictive of BAL macrophages (p < 0.0001), neutrophils (p = 0.015), IL-1 beta (p < 0.001) and IL-8 (p = 0.02). We conclude that concentrations of macrophages, neutrophils, IL-1 beta and IL-8 are elevated in the pulmonary microenvironment of smokers in a cigarette dose-dependent manner. Based on the present findings, we would caution against simple analyses that treat current smokers as a homogeneous group and which do not account for smoking intensity.
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Cites
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Cited by
Thomson, N. C., Chaudhuri, R., & Livingston, E. (2004) · European Respiratory Journal · doi:10.1183/09031936.04.00039004 · Cited by 555
Rahman, I., Marwick, J., & Kirkham, P. (2004) · Biochemical Pharmacology · doi:10.1016/j.bcp.2004.05.042 · Cited by 507
The IL-1 cytokine family and its role in inflammation and fibrosis in the lung
Borthwick, L. A. (2016) · Seminars in Immunopathology · doi:10.1007/s00281-016-0559-z · Cited by 294
Inflammatory cells in the airways in COPD
O'Donnell, R. (2006) · Thorax · doi:10.1136/thx.2004.024463 · Cited by 217
Liu, X. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.11.147 · Cited by 33
Metadata
- Authors
- Kuschner, W., D'Alessandro, A., Wong, H., & Blanc, P.
- Venue
- European Respiratory Journal
- Publisher
- European Respiratory Society (ERS)
- Published
- 1996-10-01
- Volume
- 9
- Issue
- 10
- Pages
- 1989-1994
- ISSN
- 0903-1936 (ISSN-L)
- 1399-3003
- OpenAlex
- W2125579085
- Cited by
- 371
- References
- 15
- FWCI
- 1.11
- Type
- journal article
- Language
- en
- Open access
- closed
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- Kuschner, W., D'Alessandro, A., Wong, H., & Blanc, P. (1996). Dose-dependent cigarette smoking-related inflammatory responses in healthy adults. European Respiratory Journal. https://doi.org/10.1183/09031936.96.09101989
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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