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Multiple Testing of Hypotheses in Comparing Two Groups
Abstract
Researchers frequently encounter studies that compare two groups on many variables. We discourage the use of multiple tests of hypotheses on individual variables, an approach that ignores the correlation among the variables and increases the chance of a type I error. Instead of examining each variable separately, we recommend using multivariate procedures that integrate all measures on a person into a unified analysis of the differences between the two groups. We describe three multivariate procedures: Hotelling's T2, discriminant analysis, and logistic regression. We also discuss the use of Bonferroni's adjustment to preserve the overall chance of a type I error in conducting individual tests on each variable after doing the multivariate procedures. We review the underlying assumptions and relative merits and disadvantages of the three multivariate methods and recommend which method to use in various circumstances.
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Cited by
Fox, P. T., & Raichle, M. E. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.4.1140 · Cited by 2,056
Psychosocial Factors in the Irritable Bowel Syndrome
Drossman, D. A., McKee, D. C., Sandler, R. S., Mitchell, C. M., Cramer, E. M., Lowman, B. C., & Burger, A. L. (1988) · Gastroenterology · doi:10.1016/s0016-5085(88)80017-9 · Cited by 757
Dose-dependent cigarette smoking-related inflammatory responses in healthy adults
Kuschner, W., D'Alessandro, A., Wong, H., & Blanc, P. (1996) · European Respiratory Journal · doi:10.1183/09031936.96.09101989 · Cited by 371
Gøtzsche, P. C. (1989) · Controlled Clinical Trials · doi:10.1016/0197-2456(89)90017-2 · Cited by 339
Strain, W. D., Sherwood, O., Banerjee, A., Van der Togt, V., Hishmeh, L., & Rossman, J. (2022) · Vaccines · doi:10.3390/vaccines10050652 · Cited by 122
Metadata
- Authors
- CUPPLES, L. A., HEEREN, T., SCHATZKIN, A., & COLTON, T.
- Venue
- Annals of Internal Medicine
- Publisher
- American College of Physicians
- Published
- 1984-01-01
- Volume
- 100
- Issue
- 1
- Pages
- 122-129
- ISSN
- 0003-4819 (ISSN-L)
- 1539-3704
- OpenAlex
- W2009640122
- Cited by
- 186
- References
- 0
- FWCI
- 17.46
- Type
- journal article
- Language
- en
- Open access
- closed
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- CUPPLES, L. A., HEEREN, T., SCHATZKIN, A., & COLTON, T. (1984). Multiple Testing of Hypotheses in Comparing Two Groups. Annals of Internal Medicine. https://doi.org/10.7326/0003-4819-100-1-122
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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