Cited by 463Chronic Obstructive Pulmonary Disease (COPD) ResearchCardiac Health and Mental HealthAnxiety, Depression, Psychometrics, Treatment, Cognitive Processes

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Depression and anxiety in patients with COPD

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Yohannes, Abebaw M., Alexopoulos, George S.·2014·European Respiratory Review

DOI 10.1183/09059180.00007813PMC PMC4523084

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Abstract

Under-recognised and untreated depression and anxiety symptoms have deleterious effects on physical functioning and social interaction increasing fatigue and healthcare utilisation in patients with chronic obstructive pulmonary disease (COPD). Depression and anxiety are challenging to identify and treat because their symptoms often overlap with those of COPD. The cause(s) of depression and anxiety symptoms are multifactorial and include behavioural, social and biological factors. Less than one-third of COPD patients with comorbid depression or anxiety symptoms are receiving appropriate treatment. Factors that contribute to the lack of provision of treatment are varied, they include patient perceived barriers, for example lack of knowledge and reluctance to receive antidepressant drug therapy; poor treatment compliance and lack of a standardised diagnostic approach; and scarcity of adequate resources for mental health treatment. The evidence for the efficacy of antidepressant drug therapy in patients with COPD with comorbid depression and anxiety is inconclusive. There are some promising findings regarding pulmonary rehabilitation, psychological therapy and the collaborative care model in reducing depression and anxiety symptoms in patients with COPD, but these findings are limited by short-term follow-up periods. Further work is required to examine the efficacy of these interventions in randomised controlled trials with larger samples and long-term follow-up.

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Authors: Yohannes, A. M., & Alexopoulos, G. S.
Affiliations: Manchester Metropolitan University (GB)
Corresponding author: Yohannes, Abebaw M.
ORCID: Yohannes, Abebaw M.
Alexopoulos, George S.
Venue: European Respiratory Review
Publisher: European Respiratory Society (ERS)
Published: 2014-08-31
Volume: 23
Issue: 133
Pages: 345-349
ISSN: 0905-9180 (ISSN-L)
1600-0617
DOI: 10.1183/09059180.00007813
PMC: PMC4523084
OpenAlex: W2122570705
Cited by: 463
References: 24
Citations by year: 2026: 36 · 2025: 55 · 2024: 53 · 2023: 54 · 2022: 52 · 2021: 51 · 2020: 46 · 2019: 36 · 2018: 32 · 2017: 23 · 2016: 15 · 2015: 9 · 2014: 1
FWCI: 12.81
Type: journal article
Language: en
Open access: diamond
doi.org
Locations: European Respiratory Review (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
PubMed Central (publishedVersion, cc-by-nc)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: National Institute of Mental Health (R01MH076829, P30MH085943)
Topics: Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Keywords: chronic obstructive pulmonary disease, depression, anxiety, comorbidities, antidepressant treatment, barriers to treatment, medication adherence, pulmonary rehabilitation, psychotherapy, collaborative care, mental health services
MeSH terms: Anxiety, Depression, Humans, Pulmonary Disease, Chronic Obstructive

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