The effect of treatment for sleep apnoea on determinants of blood pressure control
Open accessAbstract
Our aim was to assess the effect of continuous positive airway pressure (CPAP) on the nocturnal evolution of peripheral chemosensitivity, renin–angiotensin–aldosterone system activity, sympathetic tone and endothelial biomarkers in obstructive sleep apnoea (OSA) patients with isolated nocturnal hypertension (INH) or day–night sustained hypertension (D-NSH). In a crossover randomised trial, 32 OSA patients newly diagnosed with hypertension and without antihypertensive treatment were randomly assigned to 12 weeks of CPAP or sham CPAP. Peripheral chemosensitivity was evaluated before and after sleep using the hypoxic withdrawal test (%Δ VI). At baseline, D-NSH patients showed higher %Δ VI before sleep and higher levels of aldosterone and diurnal catecholamines. CPAP only reduced the nocturnal increase of %Δ VI in INH patients (6.9%, 95% CI 1.0–12.8%; p=0.026). CPAP-induced change from baseline in %Δ VI after sleep was 7.5% (95% CI 2.6–12.2%, p=0.005) in the INH group and 5.7% (95% CI 2.2–9.3%, p=0.004) in the D-NSH group. In contrast, %Δ VI before sleep only decreased with CPAP in the D-NSH patients (3.0%, 95% CI 0.5–5.6%; p=0.023). In conclusion, CPAP reduces the nocturnal increase of peripheral chemosensitivity experienced by INH patients and corrects the high daytime sensitivity of patients with D-NSH. Differences in response to CPAP between these patients can help better understand the mechanisms of perpetuation of hypertension in sleep apnoea.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Better oxygenation through night-time continuous positive air pressure reduces nocturnal hypertension and reduces catecholamines and aldosterone secretion.
“Further, better oxygenation through night‐time continuous positive air pressure reduces nocturnal hypertension 65 and reduces catecholamines and aldosterone secretion 66.”
From The Circadian Syndrome: is the Metabolic Syndrome and much more! (2019) · cites this paper as [66]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Miller, M. R., Hankinson, J., Brusasco, V., Burgos, F., Casaburi, R., Coates, A., Crapo, R., Enright, P., van der Grinten, C. P. M., Gustafsson, P., et al. (2005) · European Respiratory Journal · doi:10.1183/09031936.05.00034805 · Cited by 15,627 · see citing works
2013 ESH/ESC Guidelines for the management of arterial hypertension
Authors Task Force Members, Mancia, G., Fagard, R., Narkiewicz, K., Redon, J., Zanchetti, A., Böhm, M., Christiaens, T., Cífková, R., Backer, G. D., et al. (2013) · European Heart Journal · doi:10.1093/eurheartj/eht151 · Cited by 13,638 · see citing works
(2007) · Cited by 6,530 · see citing works
2007 Guidelines for the Management of Arterial Hypertension
Mancia, G., Backer, G. D., Dominiczak, A. F., Cífková, R., Fagard, R. H., Germanò, G., Grassi, G. M., Heagerty, A. M., Kjeldsen, S. E., Laurent, S., et al. (2007) · Journal of Hypertension · doi:10.1097/hjh.0b013e3281fc975a · Cited by 5,818 · see citing works
Prospective Study of the Association between Sleep-Disordered Breathing and Hypertension
Peppard, P. E., Young, T., Palta, M., & Skatrud, J. (2000) · New England Journal of Medicine · doi:10.1056/nejm200005113421901 · Cited by 4,973 · see citing works
Nieto, F. J. (2000) · JAMA · doi:10.1001/jama.283.14.1829 · Cited by 3,369 · see citing works
Standardisation of the measurement of lung volumes
Wanger, J., Clausen, J. L., Coates, A., Pedersen, O. F., Brusasco, V., Burgos, F., Casaburi, R., Crapo, R., Enright, P., van der Grinten, C. P. M., et al. (2005) · European Respiratory Journal · doi:10.1183/09031936.05.00035005 · Cited by 2,768 · see citing works
EEG Arousals: Scoring Rules and Examples
(1992) · SLEEP · doi:10.1093/sleep/15.2.173 · Cited by 2,117 · see citing works
Obstructive sleep apnoea and its cardiovascular consequences
Bradley, T. D., & Floras, J. S. (2009) · The Lancet · doi:10.1016/s0140-6736(08)61622-0 · Cited by 1,385 · see citing works
Prognostic accuracy of day versus night ambulatory blood pressure: a cohort study
Boggia, J., Li, Y., Thijs, L., Hansen, T. W., Kikuya, M., Björklund-Bodegård, K., Richart, T., Ohkubo, T., Kuznetsova, T., Torp-Pedersen, C., et al. (2007) · The Lancet · doi:10.1016/s0140-6736(07)61538-4 · Cited by 887 · see citing works
Barbé, F., Durán-Cantolla, J., Sánchez-de-la-Torre, M., Martínez-Alonso, M., Carmona, C., Barceló, A., Chiner, E., Masa, J. F., Gonzalez, M., Marín, J. M., et al. (2012) · JAMA · doi:10.1001/jama.2012.4366 · Cited by 792 · see citing works
Haentjens, P. (2007) · Archives of Internal Medicine · doi:10.1001/archinte.167.8.757 · Cited by 569 · see citing works
Bazzano, L. A., Khan, Z., Reynolds, K., & He, J. (2007) · Hypertension · doi:10.1161/hypertensionaha.106.085175 · Cited by 543 · see citing works
Obstructive sleep apnoea and cardiovascular disease
Sánchez‐de‐la‐Torre, M., Campos‐Rodríguez, F., & Barbé, F. (2012) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(12)70051-6 · Cited by 492 · see citing works
Narkiewicz, K., van de Borne, P. J. H., Montano, N., Dyken, M. E., Phillips, B. G., & Somers, V. K. (1998) · Circulation · doi:10.1161/01.cir.97.10.943 · Cited by 429 · see citing works
Barbé, F., Durán‐Cantolla, J., Sánchez‐de‐la‐Torre, M., Martínez‐Alonso, M., Carmona, C., Barceló, A., Chiner, E., Masa, J. F., González, M., Marín, J. M., et al. (2013) · Survey of Anesthesiology · doi:10.1097/01.sa.0000431218.95299.07 · Cited by 386 · see citing works
Pratt-Ubunama, M. N., Nishizaka, M. K., Boedefeld, R. L., Cofield, S. S., Harding, S. M., & Calhoun, D. A. (2007) · Chest · doi:10.1378/chest.06-1442 · Cited by 331 · see citing works
Alternative Methods of Titrating Continuous Positive Airway Pressure
Masa, J. F., Jiménez, A. L., Duran, J., Capote, F., Monasterio, C., Mayos, M., Terán, J., Hernández, L., Barbé, F., Maimó, A., et al. (2004) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200312-1787oc · Cited by 327 · see citing works
Leke, J., Fletcher, E. C., Bao, G., & Unger, T. (1997) · Journal of Hypertension · doi:10.1097/00004872-199715120-00060 · Cited by 302 · see citing works
Potentiation of sympathetic nerve responses to hypoxia in borderline hypertensive subjects.
Somers, V. K., Mark, A. L., & Abboud, F. M. (1988) · Hypertension · doi:10.1161/01.hyp.11.6.608 · Cited by 267 · see citing works
Aldosterone Excretion Among Subjects With Resistant Hypertension and Symptoms of Sleep Apnea
Calhoun, D. A., Nishizaka, M. K., Zaman, M. A., & Harding, S. M. (2004) · Chest · doi:10.1378/chest.125.1.112 · Cited by 260 · see citing works
Rio, F. G., Racionero, M. A., Pino, J. M., Martínez, I., Ortuño, F., Villasante, C., & Villamor, J. (2000) · CHEST Journal · doi:10.1378/chest.117.5.1417 · Cited by 249 · see citing works
Visceral Obesity and Insulin Resistance Are Associated with Plasma Aldosterone Levels in Women
Goodfriend, T. L., Kelley, D. E., Goodpaster, B. H., & Winters, S. J. (1999) · Obesity Research · doi:10.1002/j.1550-8528.1999.tb00418.x · Cited by 235 · see citing works
Sympathetic Over Activity in the Etiology of Hypertension of Obstructive Sleep Apnea
Fletcher, E. C. (2003) · SLEEP · doi:10.1093/sleep/26.1.15 · Cited by 231 · see citing works
Recommendations for the management of patients with obstructive sleep apnoea and hypertension
Parati, G., Lombardi, C., Hedner, J., Bonsignore, M. R., Grote, L., Tkacova, R., Lévy, P., Riha, R., Bassetti, C., Narkiewicz, K., et al. (2013) · European Respiratory Journal · doi:10.1183/09031936.00226711 · Cited by 227 · see citing works
Yvan‐Charvet, L., & Quignard‐Boulangé, A. (2010) · Kidney International · doi:10.1038/ki.2010.391 · Cited by 217 · see citing works
The renin angiotensin system and the metabolic syndrome
de Kloet, A. D., Krause, E. G., & Woods, S. C. (2010) · Physiology & Behavior · doi:10.1016/j.physbeh.2010.03.018 · Cited by 194 · see citing works
Intermittent hypoxia and vascular function: implications for obstructive sleep apnoea
Foster, G. E., Poulin, M. J., & Hanly, P. J. (2006) · Experimental Physiology · doi:10.1113/expphysiol.2006.035204 · Cited by 178 · see citing works
Thethi, T. K., Kamiyama, M., & Kobori, H. (2012) · Current Hypertension Reports · doi:10.1007/s11906-012-0245-z · Cited by 178 · see citing works
Increased sensitivity of the arterial chemoreceptor drive in young men with mild hypertension
Trzebski, A., Tafil, M., Zółtowski, M., & Przybylski, J. (1982) · Cardiovascular Research · doi:10.1093/cvr/16.3.163 · Cited by 177 · see citing works
Is Isolated Nocturnal Hypertension a Novel Clinical Entity?
Li, Y., Staessen, J. A., Lu, L., Li, L., Wang, G., & Wang, J. (2007) · Hypertension · doi:10.1161/hypertensionaha.107.087767 · Cited by 169 · see citing works
Fukuda, Y., Sato, A., & Trzebski, A. (1987) · Journal of the Autonomic Nervous System · doi:10.1016/0165-1838(87)90139-1 · Cited by 139 · see citing works
Mokhlesi, B., Hagen, E. W., Finn, L. A., Hla, K. M., Carter, J. R., & Peppard, P. E. (2015) · Thorax · doi:10.1136/thoraxjnl-2015-207231 · Cited by 135 · see citing works
Isolated Nocturnal Hypertension
Li, Y., & Wang, J. (2012) · Hypertension · doi:10.1161/hypertensionaha.111.00217 · Cited by 131 · see citing works
The role of the mineralocorticoid receptor in adipocyte biology and fat metabolism
Marzolla, V., Armani, A., Zennaro, M., Cinti, F., Mammi, C., Fabbri, A., Rosano, G. M. C., & Caprio, M. (2011) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.09.011 · Cited by 127 · see citing works
Di Murro, A., Petramala, L., Cotesta, D., Zinnamosca, L., Crescenzi, E., Marinelli, C., Saponara, M., & Letizia, C. (2010) · Journal of the Renin-Angiotensin-Aldosterone System · doi:10.1177/1470320310366581 · Cited by 125 · see citing works
Egan, B. M., Stepniakowski, K., & Goodfriend, T. L. (1994) · PubMed · doi:10.1016/0895-7061(94)p1710-h · Cited by 114 · see citing works
Aldosterone and Metabolic Syndrome
Krug, A. W., & Ehrhart‐Bornstein, M. (2008) · Hypertension · doi:10.1161/hypertensionaha.107.109439 · Cited by 103 · see citing works
Egan, B. M., Stepniakowski, K. T., & Goodfriend, T. L. (1994) · American Journal of Hypertension · doi:10.1093/ajh/7.10.886 · Cited by 94 · see citing works
Hui, A. S., Striet, J. B., Gudelsky, G. A., et al. (2003) · Hypertension · doi:10.1161/01.hyp.0000101691.12358.26 · Cited by 92 · see citing works
Chemoreflex physiology and implications for sleep apnoea: insights from studies in humans
Mansukhani, M. P., Wang, S., & Somers, V. K. (2015) · Experimental Physiology · doi:10.1113/expphysiol.2014.082826 · Cited by 67 · see citing works
Renin, ACTH, and aldosterone during acute hypercapnia and hypoxia in conscious rats
Raff, H., & Roarty, T. P. (1988) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1988.254.3.r431 · Cited by 67 · see citing works
Osanai, S., Akiba, Y., Fujiuchi, S., et al. (1999) · European Respiratory Journal · doi:10.1183/09031936.99.13241899 · Cited by 62 · see citing works
Obstructive Sleep Apnea and Aldosterone
Svatikova, A., Olson, L. J., Wolk, R. A., Phillips, B. G., Adachi, T., Schwartz, G. L., & Somers, V. K. (2009) · SLEEP · doi:10.1093/sleep/32.12.1589 · Cited by 60 · see citing works
Barceló, A., Piérola, J., Esquinas, C., de la Peña, M., Arqué, M., Alonso‐Fernández, A., Bauçà, J. M., Robles, J., Martín, B. B., & Barbé, F. (2014) · PLoS ONE · doi:10.1371/journal.pone.0084362 · Cited by 44 · see citing works
Impact of non-dipping on cardiovascular outcomes in patients with obstructive sleep apnea syndrome
Sasaki, N., Ozono, R., Edahiro, Y., Ishii, K., Seto, A., Okita, T., Teramen, K., Fujiwara, S., & Kihara, Y. (2015) · Clinical and Experimental Hypertension · doi:10.3109/10641963.2015.1057833 · Cited by 44 · see citing works
Rio, F. G., Pino, J. M., Ramírez, T., et al. (2002) · European Respiratory Journal · doi:10.1183/09031936.02.00250102 · Cited by 28 · see citing works
Cardiorespiratory Alterations Induced by Intermittent Hypoxia in a Rat Model of Sleep Apnea
Iturriaga, R., Moya, E. A., & Río, R. D. (2009) · Advances in experimental medicine and biology · doi:10.1007/978-1-4419-5692-7_55 · Cited by 24 · see citing works
Sleep-Disordered Breathing and Resistant Hypertension
Wang, A. Y.-M. (2014) · Seminars in Nephrology · doi:10.1016/j.semnephrol.2014.08.006 · Cited by 20 · see citing works
Lacedonia, D., Tamisier, R., Roche, F., Monneret, D., Baguet, J. P., Levy, P. A., & Pépin, J. (2014) · International Journal of Cardiology · doi:10.1016/j.ijcard.2014.09.123 · Cited by 19 · see citing works
Targeting autonomic imbalance in pathophysiology: is the carotid body the new nirvana?
Paton, J. F. R. (2016) · The Journal of Physiology · doi:10.1113/jp273604 · Cited by 4 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- Lesske J, Fletcher EC, Bao G, et al. Hypertension caused by chronic intermittent hypoxia -influence of chemoreceptors and sympathetic nervous system. J Hypertens 1997; 15: 1593-1603.
Cited by
Sorted by citations
The Circadian Syndrome: is the Metabolic Syndrome and much more!
Zimmet, P., Alberti, K. G. M. M., Stern, N., Bilu, C., El‐Osta, A., Einat, H., & Kronfeld‐Schor, N. (2019) · Journal of Internal Medicine · doi:10.1111/joim.12924 · Cited by 387 · see citing works
- Authors
- Casitas, R., Martínez-Cerón, E., Galera, R., Cubillos-Zapata, C., González-Villalba, M. J., Fernández-Navarro, I., Sánchez, B., García-Sánchez, A., Zamarrón, E., & García-Río, F.
- Affiliations
- Hospital Universitario La Paz (ES)
- Venue
- European Respiratory Journal
- Publisher
- European Respiratory Society (ERS)
- Published
- 2017-11
- Volume
- 50
- Issue
- 5
- Pages
- 1701261
- ISSN
- 0903-1936 (ISSN-L)
- 1399-3003
- OpenAlex
- W2768132077
- Cited by
- 17
- References
- 51
- Citations by year
- 2026: 3 · 2022: 2 · 2021: 3 · 2020: 5 · 2019: 4
- FWCI
- 1.82
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- European Respiratory Journal (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Sociedad Madrileña de Neumología y Cirugía Torácica (02-200)
- Topics
- Health Sciences › Medicine › Physiology › Obstructive Sleep Apnea Research
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Keywords
- obstructive sleep apnea, continuous positive airway pressure, isolated nocturnal hypertension, renin-angiotensin-aldosterone system, aldosterone, catecholamines, sympathetic tone, endothelial markers, blood pressure control
- MeSH terms
- Aged, Aldosterone, Blood Pressure, Catecholamines, Double-Blind Method, Female, Humans, Hypertension, Male, Middle Aged, Sleep, Spain, Treatment Outcome, Cross-Over Studies, Sleep Apnea, Obstructive, Continuous Positive Airway Pressure
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
