Peripheral blood myeloid-derived suppressor cells reflect disease status in idiopathic pulmonary fibrosis
Open accessAbstract
Idiopathic pulmonary fibrosis (IPF) is a fibroproliferative disease with irreversible lung function loss and poor survival. Myeloid-derived suppressor cells (MDSC) are associated with poor prognosis in cancer, facilitating immune evasion. The abundance and function of MDSC in IPF is currently unknown. Fluorescence-activated cell sorting was performed in 170 patients (IPF: n=69; non-IPF interstitial lung disease (ILD): n=56; chronic obstructive pulmonary disease (COPD): n=23; healthy controls: n=22) to quantify blood MDSC and lymphocyte subtypes. MDSC abundance was correlated with lung function, MDSC localisation was performed by immunofluorescence. Peripheral blood mononuclear cell (PBMC) mRNA levels were analysed by qRT-PCR. We detected increased MDSC in IPF and non-IPF ILD compared with controls (30.99±15.61% versus 18.96±8.17%, p≤0.01). Circulating MDSC inversely correlated with maximum vital capacity (r= −0.48, p≤0.0001) in IPF, but not in COPD or non-IPF ILD. MDSC suppressed autologous T-cells. The mRNA levels of co-stimulatory T-cell signals were significantly downregulated in IPF PBMC. Importantly, CD33 + CD11b + cells, suggestive of MDSC, were detected in fibrotic niches of IPF lungs. We identified increased MDSC in IPF and non-IPF ILD, suggesting that elevated MDSC may cause a blunted immune response. MDSC inversely correlate with lung function only in IPF, identifying them as potent biomarkers for disease progression. Controlling expansion and accumulation of MDSC, or blocking their T-cell suppression, represents a promising therapy in IPF.
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Elevated concentrations of peripheral blood MDSCs, defined by HLA-DR, CD33, CD11b, CD14, and CD66b, reflect poor lung function in patients with IPF.
“one recent study found that elevated concentrations of peripheral blood MDSCs, defined by the surface markers HLA-DR, CD33, CD11b, CD14, and CD66b, reflect poor lung function in patients with IPF (118).”
From The Role of Immune and Inflammatory Cells in Idiopathic Pulmonary Fibrosis (2018) · cites this paper as [118]
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The Role of Immune and Inflammatory Cells in Idiopathic Pulmonary Fibrosis
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- Authors
- Fernandez, I. E., Greiffo, F. R., Frankenberger, M., Bandres, J., Heinzelmann, K., Neurohr, C., Hatz, R., Hartl, D., Behr, J., & Eickelberg, O.
- Affiliations
- Helmholtz Munich (DE)
- LMU Klinikum (DE)
- Asklepios Fachkliniken München-Gauting (DE)
- F. Hoffmann-La Roche AG (CH)
- Venue
- European Respiratory Journal
- Publisher
- European Respiratory Society (ERS)
- Published
- 2016-09-01
- Volume
- 48
- Issue
- 4
- Pages
- 1171-1183
- ISSN
- 0903-1936 (ISSN-L)
- 1399-3003
- OpenAlex
- W2507451834
- Cited by
- 75
- References
- 59
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 14 · 2023: 6 · 2022: 6 · 2021: 10 · 2020: 8 · 2019: 5 · 2018: 6 · 2017: 11
- FWCI
- 6.55
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- European Respiratory Journal (publishedVersion)
- PubMed (publishedVersion)
- Site cant be reached (submittedVersion)
- PuSH - Publication Server of Helmholtz Zentrum München (submittedVersion)
- Funders
- German Center for Lung Research
- Helmholtz-Gemeinschaft
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
- Keywords
- idiopathic pulmonary fibrosis, myeloid-derived suppressor cells, peripheral blood, interstitial lung disease, chronic obstructive pulmonary disease, lung function, T cell suppression, disease progression biomarkers, immune evasion
- MeSH terms
- Myeloid-Derived Suppressor Cells, Aged, Cell Separation, Female, Flow Cytometry, Humans, Immune System, Leukocytes, Mononuclear, Lung, Male, Middle Aged, Prognosis, Prospective Studies, RNA, Messenger, Biomarkers, Case-Control Studies, Lung Diseases, Interstitial, Disease Progression, Coculture Techniques, Pulmonary Disease, Chronic Obstructive, Idiopathic Pulmonary Fibrosis
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