Guidance for the management of hirsutism
Abstract
Approximately 80% of women are affected by the presence of excessive hair growth in a 'male-like' pattern. Excessive facial hair in particular can be a source of distress to such women and can lead to psychological problems such as anxiety, depression and a reduced quality of life.Current cosmetic methods of hair removal include shaving, depilatories, waxing, plucking, laser, intense pulsed light (IPL) and electrolysis.A topical treatment cream such as eflornithine 11.5% can slow hair growth and thus reduce the frequency of the need for hair removal. This treatment can be used effectively in conjunction with hair removal methods.
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Negative body image also predicts depression and anxiety.
“Negative body image also predicts depression and anxiety. 116,117”
From Assessment and management of polycystic ovary syndrome: Summary of an evidence-based guideline (2011) · cites this paper as [116]
Cites
Male hormone stimulation is prerequisite and an incitant in common baldness
Hamilton, J. B. (1942) · American Journal of Anatomy · doi:10.1002/aja.1000710306 · Cited by 469 · see citing works
The evaluation and management of hirsutism*1
Azziz, R. (2003) · Obstetrics and Gynecology · doi:10.1016/s0029-7844(02)02725-4 · Cited by 247 · see citing works
Metformin or Antiandrogen in the Treatment of Hirsutism in Polycystic Ovary Syndrome
Harborne, L., Fleming, R., Lyall, H., Sattar, N. A., & Norman, J. E. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-030424 · Cited by 204 · see citing works
Quality of life of hirsute women
Sonino, N., Fava, G. A., Mani, E., Belluardo, P., & Boscaro, M. (1993) · Postgraduate Medical Journal · doi:10.1136/pgmj.69.809.186 · Cited by 193 · see citing works
Guido, M., Romualdi, D., Giuliani, M., Suriano, R., Selvaggi, L. E., Apa, R., & Lanzone, A. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031158 · Cited by 158 · see citing works
Wendelin, D. S., Pope, D. N., & Mallory, S. B. (2003) · Journal of the American Academy of Dermatology · doi:10.1067/mjd.2003.100 · Cited by 137 · see citing works
Balfour, J. A. B., & McClellan, K. J. (2001) · American Journal of Clinical Dermatology · doi:10.2165/00128071-200102030-00009 · Cited by 128 · see citing works
A randomized controlled trial of laser treatment among hirsute women with polycystic ovary syndrome
Clayton, W. J., Lipton, M., Elford, J., Rustin, M., & Sherr, L. (2005) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2005.06426.x · Cited by 127 · see citing works
Psychological morbidity in women referred for treatment of hirsutism
Barth, J. H., Catalan, J. M., Cherry, C. A., & Day, A. (1993) · Journal of Psychosomatic Research · doi:10.1016/0022-3999(93)90056-l · Cited by 108 · see citing works
Cyproterone acetate for severe hirsutism:results of a double‐blind dose‐ranging study*
Barth, J. H., Cherry, C. A., WOJNAROWSKA, F. T., & Dawber, R. P. R. (1991) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1991.tb03489.x · Cited by 103 · see citing works
Self-citationHandrick, C., & Alster, T. S. (2001) · Dermatologic Surgery · doi:10.1046/j.1524-4725.2001.00338.x · Cited by 97 · see citing works
Long-Pulsed 1064-nm Nd:YAG Laser-Assisted Hair Removal in All Skin Types
Tanzi, E. L., & Alster, T. S. (2004) · Dermatologic Surgery · doi:10.1111/j.1524-4725.2004.30007.x · Cited by 96 · see citing works
Evaluation and treatment of women with hirsutism.
Hunter, M. H., & Carek, P. J. (2003) · PubMed · Cited by 73 · see citing works
Rittmaster, R. S. (1997) · The Lancet · doi:10.1016/s0140-6736(96)07252-2 · Cited by 73 · see citing works
Keleştimur, F., Everest, H., Unluhizarci, K., Bayram, F., & Sahin, Y. (2004) · European Journal of Endocrinology · doi:10.1530/eje.0.1500351 · Cited by 53 · see citing works
Hair removal by lasers and intense pulsed light sources
Dierickx, C. C. (2000) · Seminars in Cutaneous Medicine and Surgery · doi:10.1053/sder.2000.18368 · Cited by 43 · see citing works
Finasteride versus cyproterone acetate-estrogen regimens in the treatment of hirsutism
Beigi, A., Sobhi, A., & Zarrinkoub, F. (2004) · International Journal of Gynecology & Obstetrics · doi:10.1016/j.ijgo.2004.06.003 · Cited by 43 · see citing works
Relative Safety and Efficacy of Finasteride for Treatment of Hirsutism
Townsend, K. A., & Marlowe, K. F. (2004) · Annals of Pharmacotherapy · doi:10.1345/aph.1d461 · Cited by 36 · see citing works
Psychosomatic Assessment of Hirsute Women
Fava, G. A., Grandi, S., Savron, G., Bartolucci, G., Santarsiero, G., Trombini, G., & Orlandi, C. (2010) · Psychotherapy and Psychosomatics · doi:10.1159/000288142 · Cited by 33 · see citing works
Removal of unwanted facial hair.
Shenenberger, D. W., & Utecht, L. M. (2002) · PubMed · Cited by 30 · see citing works
Low-Dose Flutamide (125 mg/Day) as Maintenance Therapy in the Treatment of Hirsutism
Venturoli, S., Paradisi, R., Bagnoli, A., Colombo, F. M., Ravaioli, B., Vianello, F., Mancini, F., Gualerzi, B., Porcu, E., & Seracchioli, R. (2001) · Hormone Research in Paediatrics · doi:10.1159/000048086 · Cited by 27 · see citing works
Epilation with a long-pulse 1064nm Nd:YAG laser in facial hirsutism
Lévy, J.-L., Trelles, M. A., & de Ramecourt, A. (2001) · Journal of Cutaneous Laser Therapy · doi:10.1080/14764170160260753 · Cited by 23 · see citing works
Hair reduction: 48 months of experience with 800nm diode laser
Kopera, D. (2003) · Journal of Cosmetic and Laser Therapy · doi:10.1080/14764170310001438 · Cited by 23 · see citing works
Ahmed, B., & Jaspan, J. B. (1994) · The American Journal of the Medical Sciences · doi:10.1097/00000441-199411000-00007 · Cited by 9 · see citing works
Martínez, F. M. C. (2000) · Dialnet (Universidad de la Rioja) · Cited by 3 · see citing works
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Assessment and management of polycystic ovary syndrome: Summary of an evidence-based guideline
Teede, H. J., Misso, M. L., Deeks, A. A., Moran, L. J., Stuckey, B. G. A., Wong, J. L. A., Norman, R. J., Costello, M. F., & Groups, O. B. O. T. G. D. (2011) · Medical Journal of Australia · doi:10.5694/mja11.10915 · Cited by 379 · see citing works
Lifestyle management in polycystic ovary syndrome – beyond diet and physical activity
Cowan, S., Lim, S. S., Alycia, C., Pirotta, S., Thomson, R. L., Gibson‐Helm, M. E., Blackmore, R., Naderpoor, N., Bennett, C., Ee, C., et al. (2023) · BMC Endocrine Disorders · doi:10.1186/s12902-022-01208-y · Cited by 285 · see citing works
“Features of PCOS, in particular hirsutism and increased weight, have also been shown to negatively affect body image [27, 28], with poor body image being strongly related to depression in women with PCOS [29, 30].”
BackgroundWomen living with facial hair: the psychological and behavioral burden
Lipton, M. G., Sherr, L., Elford, J., Rustin, M. H. A., & Clayton, W. J. (2006) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2006.01.016 · Cited by 118 · see citing works
“, on the face, chest, abdomen, back) [1].”
Medical treatment of hirsutism
Blume‐Peytavi, U., & Hahn, S. (2008) · Dermatologic Therapy · doi:10.1111/j.1529-8019.2008.00215.x · Cited by 77 · see citing works
“Finasteride has been evaluated for treatment of hirsutism in many randomized and observational trials (28,29).”
BackgroundHirsutism: an evidence-based treatment update
Somani, N., & Turvy, D. (2014) · American Journal of Clinical Dermatology · doi:10.1007/s40257-014-0078-4 · Cited by 69 · see citing works
“Eflornithine irreversibly inhibits L-ornithine decarboxylase, thereby impeding formation of a polyamine critical to regulating cellular growth and differentiation in the hair follicle [22].”
BackgroundGuidelines for laser hair removal
Casey, A. S., & Goldberg, D. J. (2008) · Journal of Cosmetic and Laser Therapy · doi:10.1080/14764170701817049 · Cited by 53 · see citing works
“damage to the surrounding tissues, resulting in permanent scarring (24).”
BackgroundEffect of body mass index on clinical manifestations in patients with polycystic ovary syndrome
Tamimi, W. G., Siddiqui, I., Tamim, H., AlEisa, N., & Adham, M. (2009) · International Journal of Gynecology & Obstetrics · doi:10.1016/j.ijgo.2009.06.003 · Cited by 46 · see citing works
“Whereas hypertrichosis is uniformly distributed, usually familial, and associated with endocrine dysfunction (such as thyroid malfunction) or with a drug (such as phenytoin), hirsutism is defined as the excessive presence of terminal hair in androgen-dependent areas of a woman's body [4].”
BackgroundLapidoth, M., Dierickx, C. C., Lanigan, S. W., Paasch, U., Campo-Voegeli, A., Dahan, S., Marini, L., & Adatto, M. (2010) · Dermatology · doi:10.1159/000315499 · Cited by 41 · see citing works
“where the development of UFH is typically gradual in onset [”
BackgroundEe, C., Smith, C., Moran, L., MacMillan, F., Costello, M., Baylock, B., & Teede, H. (2020) · BMC Women's Health · doi:10.1186/s12905-020-01090-7 · Cited by 35 · see citing works
Srivilai, J., Phimnuan, P., Jaisabai, J., Luangtoomma, N., Waranuch, N., Khorana, N., Wisuitiprot, W., Scholfield, C. N., Champachaisri, K., & Ingkaninan, K. (2016) · Phytomedicine · doi:10.1016/j.phymed.2016.12.007 · Cited by 36 · see citing works
Unwanted facial hair removal with laser treatment improves quality of life of patients
Maziar, A., Farsi, N., Mandegarfard, M., Babakoohi, S., Gorouhi, F., Dowlati, Y., & Firooz, A. (2010) · Journal of Cosmetic and Laser Therapy · doi:10.3109/14764170903449802 · Cited by 34 · see citing works
Treatments for unwanted facial hair.
Shapiro, J., & Lui, H. (2005) · PubMed · Cited by 33 · see citing works
Idiopathic hirsutism: excessive bodily and facial hair in women
Elghblawi, E. (2008) · British Journal of Nursing · doi:10.12968/bjon.2008.17.3.28410 · Cited by 15 · see citing works
Interventional Studies for Polycystic Ovarian Syndrome in Children and Adolescents
Vuguin, P. M. (2010) · Pediatric Health · doi:10.2217/phe.09.69 · Cited by 14 · see citing works
“Cosmetic treatment Cosmetic and dermatologic treatments for the treatment of hirsutism include depilation, epilation or destruction of the dermal papilla with electrolysis or laser [103–106].”
BackgroundThe Story Plot of Living the Embarrassment of Hirsutism
Pate, C. M. (2013) · Archives of Psychiatric Nursing · doi:10.1016/j.apnu.2013.02.003 · Cited by 14 · see citing works
“Often times this hair is noted on the face, back, or chest (Dawber, 2005).”
BackgroundSiddiqui, I., Tamimi, W. G., Tamim, H., AlEisa, N., & Adham, M. (2009) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-009-1124-y · Cited by 14 · see citing works
“restricted to androgen-dependent areas only [5].”
Kunte, C., Wolff, H., Gottschaller, C., & Hohenleutner, U. (2007) · JDDG Journal der Deutschen Dermatologischen Gesellschaft · doi:10.1111/j.1610-0387.2007.06098.x · Cited by 12 · see citing works
Efficacy and safety of a 0.65 millisecond pulsed portable ND:YAG laser for hair removal
Khatri, K. A., Lee, R. A., Goldberg, L. J., Khatri, B., & Garcia, V. (2009) · Journal of Cosmetic and Laser Therapy · doi:10.1080/14764170802612976 · Cited by 11 · see citing works
“A very high fluence and a very long pulse can cause excessive heat damage which can lead to permanent scarring (7).”
BackgroundSrivilai, J., Nontakhot, K., Nutuan, T., Waranuch, N., Khorana, N., Wisuthiprot, W., Scholfield, C. N., Champachaisri, K., & Ingkaninan, K. (2018) · Skin Pharmacology and Physiology · doi:10.1159/000486136 · Cited by 9 · see citing works
Pathania, Y. S., Budania, A., Rafi, S., & Kumar, A. (2023) · Journal of Cosmetic Dermatology · doi:10.1111/jocd.15655 · Cited by 8 · see citing works
Pastoor, H., Both, S., Timman, R., Laan, E. T. M., & Laven, J. S. E. (2020) · Sexual Medicine · doi:10.1016/j.esxm.2020.07.002 · Cited by 8 · see citing works
“A negative body image is strongly associated with depression.(27,29,30) Finally, disordered eating, eating disorders (mainly bulimia nervosa), and risk factors for eating disorders seem to be more prevalent in women with PCOS.”
BackgroundIssues Faced by Women With Hirsutism: State of the Science
Pate, C. M. (2015) · Health Care For Women International · doi:10.1080/07399332.2015.1078805 · Cited by 7 · see citing works
“Often times this hair is noted on the face, back, or chest (Dawber, 2005).”
BackgroundEfficacy of Intense Pulsed Light in Hirsutism
Khodaeiani, E., Amirnia, M., Nazhad, S. B., Alikhah, H., & Brufeh, B. (2010) · Pakistan Journal of Biological Sciences · doi:10.3923/pjbs.2010.635.641 · Cited by 7 · see citing works
An unusual case of oral hirsutism in a patient with polycystic ovarian syndrome
Femiano, F., Rullo, R., Serpico, R., Lanza, A., Festa, V. M., & Laino, G. (2009) · Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology · doi:10.1016/j.tripleo.2009.07.045 · Cited by 5 · see citing works
Nd:YAG Technology for Laser Hair Removal: What's New?
Nuchanatanon, T., Jurairattanaporn, N., & Vachiramon, V. (2024) · Dermatological Reviews · doi:10.1002/der2.249 · Cited by 2 · see citing works
Rabe, T., Albring, C., Blume‐Peytavi, U., Egarter, C., Geisthövel, F., König, K., Kühl, H., Merkle, E., Ao, M., Reisch, N., et al. (2015) · Journal für Reproduktionsmedizin und Endokrinologie · Cited by 2 · see citing works
Saeed, B. T. (2020) · Kurdistan Journal of Applied Research · doi:10.24017/science.2020.ichms2020.5 · Cited by 2 · see citing works
Geisthövel, F. (2012) · Journal für Kardiologie (Krause & Pachernegg GmbH) · Cited by 2 · see citing works
The Relationship between Clinical and Chemical Hyperandrogenism in 14-18-Years- Old Girls
Akbarzadeh, M., Naderi, T., Dabbaghmanesh, M. H., Tabatabaee, H., & Zareh, Z. (2012) · Zahedan Journal of Research in Medical Sciences · Cited by 1 · see citing works
Zahoor, I., Singh, S., Sharma, N., Grewal, I. K., & Wani, S. N. (2023) · Pharmaceutical Sciences · doi:10.34172/ps.2023.24 · Cited by 1 · see citing works
“32,34 Pharmaceutical Sciences, 2024, 30(1), 54-69 | 58”
BackgroundRehman, F. U., & Niazi, N. A. K. (2008) · Annals of King Edward Medical University · doi:10.21649/akemu.v14i1.103 · Cited by 1 · see citing works
An ideal laser for hair reduction in ethnic skin
Lotti, T., & University of Rome "G.Marconi" Rome (2015) · Global Dermatology · doi:10.15761/god.1000120 · Cited by 1 · see citing works
“Hirsutism refers to the growth of coarse terminal hair in females that follows a male like pattern, most commonly in the upper lip area, beard area, abdomen, or chest [1-4].”
Background(2008) · Series in cosmetic and laser therapy · doi:10.3109/9781420091496.008 · Cited by 1 · see citing works
Goldberg, D. J. (2009) · Elsevier eBooks · doi:10.1016/b978-0-7020-3090-1.00010-0 · Cited by 1 · see citing works
Dhanalakshmi, G., Palaniswamy, S., & Pasupathy, P. (2012)
Update on the management of hirsutism
Act, A. (2010)
A Phenomenological Study of Living with Excess Facial Hair for African-American Women
Pate, C. M. (2015) · doi:10.33915/etd.6383
“Often times this hair is noted on the face, back, or chest (Dawber, 2005).”
BackgroundOrmiga, P., & Aguinaga, F. (2016) · Springer eBooks · doi:10.1007/978-3-319-20251-8_16-1
Al-Rubaie, B. J. U., Al-Mukhtar, N. J. H., & Al-Shemmary, B. D. (2011) · Medical Journal of Babylon
Ormiga, P., & Aguinaga, F. (2018) · Clinical approaches and procedures in cosmetic dermatology · doi:10.1007/978-3-319-16799-2_16
Ee, C., Smith, C. T., Moran, L., MacMillan, F., Costello, M., Baylock, B., & Teede, H. (2020) · Figshare · doi:10.6084/m9.figshare.13046793
- Authors
- Dawber, R. P. R.
- Affiliations
- Churchill Hospital (GB)
- Corresponding author
- Dawber, Rodney P. R.
- Venue
- Current Medical Research and Opinion
- Publisher
- Informa Healthcare
- Published
- 2005-07-06
- Volume
- 21
- Issue
- 8
- Pages
- 1227-1234
- ISSN
- 0300-7995 (ISSN-L)
- 1473-4877
- OpenAlex
- W2107755737
- Cited by
- 42
- References
- 25
- Citations by year
- 2024: 1 · 2023: 3 · 2020: 4 · 2018: 2 · 2016: 3 · 2015: 4 · 2014: 1 · 2013: 1 · 2012: 3
- FWCI
- 2.80
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Medical Research and Opinion (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Shire
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Health Sciences › Medicine › Dermatology › Dermatologic Treatments and Research
- Health Sciences › Medicine › Urology › Hair Growth and Disorders
- Keywords
- hirsutism, cosmetic hair removal, difluoromethylornithine, laser hair removal, intense pulsed light, electrolysis, waxing, psychological distress, quality of life
- MeSH terms
- Administration, Topical, Eflornithine, Cosmetic Techniques, Enzyme Inhibitors, Female, Hair Removal, Hirsutism, Humans, Polycystic Ovary Syndrome
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