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Cited by 127Ovarian function and disordersDermatologic Treatments and ResearchAcne and Rosacea Treatments and Effects

A randomized controlled trial of laser treatment among hirsute women with polycystic ovary syndrome

Clayton, W.J., Lipton, M., Elford, J., Rustin, M., Sherr, L.·2005·British Journal of Dermatology
DOI 10.1111/j.1365-2133.2005.06426.x
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Abstract

BACKGROUND: Facial hirsutism is one of the characteristic features of polycystic ovary syndrome (PCOS), and this can lead to high levels of depression and anxiety. OBJECTIVES: To evaluate the impact of laser treatment on the severity of facial hirsutism and on psychological morbidity in women with PCOS. METHODS: A randomized controlled trial of five high-fluence treatments (intervention) vs. five low-fluence treatments (control) was performed over 6 months in a National Health Service teaching hospital. Subjects were 88 women with facial hirsutism due to PCOS recruited from hospital outpatient clinics and a patient support group in 2001-2002. The main outcomes were self-reported severity of facial hair (measured on a scale of 1-10), depression, anxiety (measured on the Hospital Anxiety and Depression Scale) and quality of life (measured on the WHOQOL-BREF). RESULTS: Self-reported severity of facial hair in the intervention group (n = 51) fell from 7.3 to 3.6 over the 6-month study period; for the control group (n = 37) the corresponding scores were 7.1 and 6.1. The change was significantly greater in the intervention group [ancova F((1,83)) = 24.5, P < 0.05]. Self-reported time spent on hair removal declined from 112 to 21 min per week in the intervention group and from 92 to 56 min in the control group [F((1,80)) = 10.2, P </= 0.05]. Mean depression scores fell from 6.7 to 3.6 in the intervention group, compared with 6.1 to 5.4 in the control group [F((1,83)) = 14.7, P < 0.05]. A similar change was seen for mean anxiety scores: intervention 11.1 to 8.2, control 9.6 to 9.3 [F((1,84)) = 17.8, P < 0.05]. Psychological quality of life also improved more in the intervention group, from 49.6 to 61.2 vs. 50.1 to 51.5 in the control group [F((1,84)) = 10.9, P < 0.05]. CONCLUSIONS: Laser treatment appeared to reduce the severity of facial hair and time spent on hair removal as well as alleviating depression and anxiety in women with PCOS. These findings suggest that ways of making this method of hair removal more widely available to women with facial hirsutism should be considered.

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Authors
Clayton, W. J., Lipton, M., Elford, J., Rustin, M., & Sherr, L.
Affiliations
Royal Free London NHS Foundation Trust (GB)
Corresponding author
Clayton, W.J.
ORCID
Venue
British Journal of Dermatology
Publisher
Oxford University Press (OUP)
Published
2005-05
Volume
152
Issue
5
Pages
986-992
ISSN
  • 0007-0963 (ISSN-L)
  • 1365-2133
DOI
10.1111/j.1365-2133.2005.06426.x
OpenAlex
W2159113412
Cited by
127
References
23
Citations by year
2026: 3 · 2025: 4 · 2024: 3 · 2023: 4 · 2022: 4 · 2021: 2 · 2020: 2 · 2019: 8 · 2018: 6 · 2017: 4 · 2016: 4 · 2015: 8 · 2014: 6 · 2013: 2 · 2012: 11
FWCI
10.86
Type
journal article
Language
en
Open access
closed
Licence
doi.wiley.com/10.1002/tdm_license_1.1 (tdm, 3775 d)
Locations
  • British Journal of Dermatology (publishedVersion)
  • PubMed (publishedVersion)
  • UCL Discovery (University College London) (submittedVersion)
  • Digest of the World Core Medical Journals
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
  • Health Sciences › Medicine › Dermatology › Dermatologic Treatments and Research
  • Health Sciences › Medicine › Dermatology › Acne and Rosacea Treatments and Effects
Keywords
polycystic ovary syndrome, laser hair removal, depression, anxiety, quality of life, psychological morbidity, women's health, patient support groups, cost-effectiveness, patient satisfaction
MeSH terms
Adult, Anxiety, Depression, Facial Dermatoses, Female, Hair Removal, Hirsutism, Humans, Polycystic Ovary Syndrome, Psychiatric Status Rating Scales, Quality of Life, Severity of Illness Index, Treatment Outcome, Patient Satisfaction, Laser Therapy

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